Dose Response of Influenza A/Washington/897/80 (H3N2) Cold-Adapted Reassortant Virus in Adult Volunteers

1984 ◽  
Vol 149 (5) ◽  
pp. 814-815 ◽  
Author(s):  
M. L. Clements ◽  
R. F. Betts ◽  
H. F. Maassab ◽  
B. R. Murphy
Keyword(s):  
Dose Response ◽  
Influenza A ◽  
Reassortant Virus ◽  
Cold Adapted ◽  
Adult Volunteers

Dose Response of Cold-Adapted, Reassortant Influenza A/California/10/78 Virus (H1N1) in Adult Volunteers

1984 ◽  
Vol 149 (5) ◽  
pp. 816-816 ◽  
Author(s):  
B. R. Murphy ◽  
M. L. Clements ◽  
H. P. Madore ◽  
J. Steinberg ◽  
S. O'Donnell ◽  
...  
Keyword(s):  
Dose Response ◽  
Influenza A ◽  
Virus H1n1 ◽  
Cold Adapted ◽  
Adult Volunteers

Dose Response of Influenza A/Washington/897/80 (H3N2) Avian-Human Reassortant Virus in Adult Volunteers

1985 ◽  
Vol 152 (1) ◽  
pp. 225-229 ◽  
Author(s):  
B. R. Murphy ◽  
M. L. Clements ◽  
E. L. Tierney ◽  
R. E. Black ◽  
J. Stienberg ◽  
...  
Keyword(s):  
Dose Response ◽  
Influenza A ◽  
Reassortant Virus ◽  
Adult Volunteers

scholarly journals Serological evaluation of an influenza A virus cold-adapted reassortant live vaccine, CR-37 (H1N1), in Japanese adult volunteers

1984 ◽  
Vol 92 (2) ◽  
pp. 231-242 ◽  
Author(s):  
N. Yamane ◽  
Y. Nakamura ◽  
M. Yuki ◽  
T. Odagiri ◽  
N. Ishida
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Skin Tests ◽  
Wild Type Virus ◽  
Low Grade ◽  
Japanese Adult ◽  
Live Virus ◽  
Cold Adapted ◽  
Vaccine Preparation ◽  
Adult Volunteers

SUMMARYA cold-adapted influenza A virus, CR-37 (H1N1), derived from genetic reassortment between A/Ann Arbor/6/60 (H2N2) cold-adapted variant virus and A/California/10/78 (H1N1) wild-type virus, was tested in Japanese adult volunteers. The CR-37 live virus preparation induced only low-grade clinical reactionsin volunteers for the first 3–4 days after inoculation. Two vaccinees who did not show any antibody changes became febrile (over 38–0 °C). Skin tests using the vaccine preparation and uninfected allantoic fluid were performed, and indicated that one of these two vaccinees was positive for the CR-37 vaccine preparation. A high proportion of the vaccinees whose sera had a haemagglutination-inhibition (HI) antibody titre against thevaccine strain of ≤ 64 before inoculation, seroconverted in both HI and neuraminidase-inhibition (NA1) antibody titrations, and only a few seroconverted in the titration of antibody against type-specific internal antigens. The serological examinations against heterotypic H1N1 variants indicated that the cold-adapted live influenza virus vaccine could induce a broad spectrum of HI antibody reactivity and immunity of long duration.

Comparison of Live Attenuated Cold-Adapted and Avian-Human Influenza A/Bethesda/85 (H3N2) Reassortant Virus Vaccines in Infants and Children

1990 ◽  
Vol 162 (2) ◽  
pp. 394-401 ◽  
Author(s):  
M. C. Steinhoff ◽  
N. A. Halsey ◽  
M. H. Wilson ◽  
B. A. Burns ◽  
R. K. Samorodin ◽  
...  
Keyword(s):  
Influenza A ◽  
Infants And Children ◽  
Human Influenza ◽  
Reassortant Virus ◽  
Cold Adapted ◽  
In Infants And Children

Safety and immunogenicity of a cold-adapted influenza A (H1N1) reassortant virus vaccine administered to infants less than six months of age

1995 ◽  
Vol 14 (1) ◽  
pp. 10-16 ◽  
Author(s):  
RUTH A. KARRON ◽  
MARK C. STEINHOFF ◽  
E. KANTA SUBBARAO ◽  
MODENA H. WILSON ◽  
KATHLEEN MACLEOD ◽  
...  
Keyword(s):  
Virus Vaccine ◽  
Influenza A ◽  
Reassortant Virus ◽  
Cold Adapted ◽  
Influenza A H1n1
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