Evaluation of influenza A and B cold-adapted reassortant virus reproduction in trivalent live influenza vaccines

2021 ◽  
pp. 198396
Author(s):  
G. Landgraf ◽  
Y.A. Desheva ◽  
L.G. Rudenko
Keyword(s):  
Influenza A ◽  
Influenza Vaccines ◽  
Reassortant Virus ◽  
Cold Adapted ◽  
Virus Reproduction

Comparison of Live Attenuated Cold-Adapted and Avian-Human Influenza A/Bethesda/85 (H3N2) Reassortant Virus Vaccines in Infants and Children

1990 ◽  
Vol 162 (2) ◽  
pp. 394-401 ◽  
Author(s):  
M. C. Steinhoff ◽  
N. A. Halsey ◽  
M. H. Wilson ◽  
B. A. Burns ◽  
R. K. Samorodin ◽  
...  
Keyword(s):  
Influenza A ◽  
Infants And Children ◽  
Human Influenza ◽  
Reassortant Virus ◽  
Cold Adapted ◽  
In Infants And Children

Dose Response of Influenza A/Washington/897/80 (H3N2) Cold-Adapted Reassortant Virus in Adult Volunteers

1984 ◽  
Vol 149 (5) ◽  
pp. 814-815 ◽  
Author(s):  
M. L. Clements ◽  
R. F. Betts ◽  
H. F. Maassab ◽  
B. R. Murphy
Keyword(s):  
Dose Response ◽  
Influenza A ◽  
Reassortant Virus ◽  
Cold Adapted ◽  
Adult Volunteers

scholarly journals Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines

Viruses ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 928 ◽  
Author(s):  
Laura Rodriguez ◽  
Pilar Blanco-Lobo ◽  
Emma C. Reilly ◽  
Tatsuya Maehigashi ◽  
Aitor Nogales ◽  
...  
Keyword(s):  
Influenza A ◽  
Viral Disease ◽  
The United States ◽  
Influenza Viruses ◽  
Influenza Vaccines ◽  
Temperature Sensitive ◽  
Cold Adapted ◽  
Ann Arbor

Influenza viruses cause annual, seasonal infection across the globe. Vaccination represents the most effective strategy to prevent such infections and/or to reduce viral disease. Two major types of influenza vaccines are approved for human use: inactivated influenza vaccines (IIVs) and live attenuated influenza vaccines (LAIVs). Two Master Donor Virus (MDV) backbones have been used to create LAIVs against influenza A virus (IAV): the United States (US) A/Ann Arbor/6/60 (AA) and the Russian A/Leningrad/134/17/57 (Len) H2N2 viruses. The mutations responsible for the temperature sensitive (ts), cold-adapted (ca) and attenuated (att) phenotypes of the two MDVs have been previously identified and genetically mapped. However, a direct comparison of the contribution of these residues to viral attenuation, immunogenicity and protection efficacy has not been conducted. Here, we compared the In vitro and in vivo phenotype of recombinant influenza A/Puerto Rico/8/34 H1N1 (PR8) viruses containing the ts, ca and att mutations of the US (PR8/AA) and the Russian (PR8/Len) MDVs. Our results show that PR8/Len is more attenuated in vivo than PR8/AA, although both viruses induced similar levels of humoral and cellular responses, and protection against homologous and heterologous viral challenges. Our findings support the feasibility of using a different virus backbone as MDV for the development of improved LAIVs for the prevention of IAV infections.

Safety and immunogenicity of a cold-adapted influenza A (H1N1) reassortant virus vaccine administered to infants less than six months of age

1995 ◽  
Vol 14 (1) ◽  
pp. 10-16 ◽  
Author(s):  
RUTH A. KARRON ◽  
MARK C. STEINHOFF ◽  
E. KANTA SUBBARAO ◽  
MODENA H. WILSON ◽  
KATHLEEN MACLEOD ◽  
...  
Keyword(s):  
Virus Vaccine ◽  
Influenza A ◽  
Reassortant Virus ◽  
Cold Adapted ◽  
Influenza A H1n1
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