scholarly journals Induction of Immunologic Memory in Gambian Children by Vaccination in Infancy with a Group A plus Group C Meningococcal Polysaccharide-Protein Conjugate Vaccine

1997 ◽  
Vol 175 (1) ◽  
pp. 200-204 ◽  
Author(s):  
A. Leach ◽  
P. A. Twumasi ◽  
S. Kumah ◽  
W. S. Banya ◽  
S. Jaffar ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Immunologic Memory ◽  
Protein Conjugate ◽  
Group A

scholarly journals Disparity in Functional Activity between Serum Anticapsular Antibodies Induced in Adults by Immunization with an Investigational Group A and C Neisseria meningitidis-Diphtheria Toxoid Conjugate Vaccine and by a Polysaccharide Vaccine

2003 ◽  
Vol 71 (6) ◽  
pp. 3402-3408 ◽  
Author(s):  
Shannon L. Harris ◽  
Adam Finn ◽  
Dan M. Granoff
Keyword(s):  
Conjugate Vaccine ◽  
Functional Activity ◽  
Geometric Mean ◽  
Polysaccharide Vaccine ◽  
Vaccine Group ◽  
Avidity Index ◽  
Passive Protection ◽  
Infant Rats ◽  
Protein Conjugate ◽  
Group A

ABSTRACT Polysaccharide-protein conjugate vaccines elicit higher concentrations of serum anticapsular antibody in infants and children than do unconjugated polysaccharide vaccines. The conjugate-induced antibodies also have higher avidity and complement-mediated bactericidal activity. Similar vaccine-related differences in the magnitude or functional activity of antibody are observed infrequently in immunized adults. We compared the antibody responses of adults immunized with an investigational group A and C meningococcal conjugate vaccine to those elicited by an unconjugated meningococcal polysaccharide vaccine. Although there were no significant differences between the respective geometric mean bactericidal titers of the two vaccine groups, it took, on average, three- to fourfold higher concentrations of polysaccharide-induced serum anticapsular antibody to achieve 50% complement-mediated bacteriolysis than conjugate-induced antibody (P < 0.001 for groups A and C). At limiting doses, the polysaccharide-induced anticapsular antibodies also were less effective in conferring passive protection against meningococcal bacteremia in infant rats challenged with a group C strain (P < 0.04). The avidity index of the group C antibodies was higher in the conjugate vaccine group than in the polysaccharide vaccine group (P < 0.005). The disparities in the functional activity of the anticapsular antibodies elicited in adults by the two vaccines imply fundamental differences in the respective B-cell populations stimulated.

scholarly journals Ethical Challenges and Lessons Learned During the Clinical Development of a Group A Meningococcal Conjugate Vaccine

2015 ◽  
Vol 61 (suppl_5) ◽  
pp. S422-S427 ◽  
Author(s):  
Lionel Martellet ◽  
Samba O. Sow ◽  
Aldiouma Diallo ◽  
Abraham Hodgson ◽  
Beate Kampmann ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Clinical Development ◽  
Lessons Learned ◽  
Ethical Challenges ◽  
Group A

Change in Bacterial Causes of Community-Acquired Parapneumonic Effusion and Pleural Empyema in Children 6 Years After 13-Valent Pneumococcal Conjugate Vaccine Implementation

2018 ◽  
Vol 8 (5) ◽  
pp. 474-477 ◽  
Author(s):  
Fouad Madhi ◽  
Corinne Levy ◽  
Laurence Morin ◽  
Philippe Minodier ◽  
François Dubos ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Group A Streptococcus ◽  
Pneumococcal Infection ◽  
Pleural Empyema ◽  
Parapneumonic Effusion ◽  
Before And After ◽  
Group A

AbstractWe describe here changes in the bacterial causes of pleural empyema before and after implementation of the 13-valent pneumococcal conjugate vaccine (PCV13) program in France (2009–2017). For 220 (39.3%) of 560 children, a bacterial cause was found. The frequency of pneumococcal infection decreased during the study from 79.1% in 2009 to 36.4% in 2017 (P < .001). Group A streptococcus is now the leading cause of documented empyema (45.5%).

scholarly journals Serum Opsonic Activity for Streptococcus pneumoniae Types 6B and 14 in Infants with Sickle Cell Disease after Immunization with Pneumococcal Protein Conjugate Vaccine

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 11A-11A
Author(s):  
Anna H Nowak-Wegrzyn ◽  
Jerry A Winkelstein ◽  
Beth M Stover ◽  
Andrea J Swift ◽  
Howard M Lederman
Keyword(s):  
Streptococcus Pneumoniae ◽  
Sickle Cell Disease ◽  
Conjugate Vaccine ◽  
Sickle Cell ◽  
Cell Disease ◽  
Opsonic Activity ◽  
Protein Conjugate

scholarly journals Meningococcal Group A, C, W, and Y Tetanus Toxoid Conjugate Vaccine: A Review of Clinical Data in Adolescents

2018 ◽  
Vol 63 (3) ◽  
pp. 269-279 ◽  
Author(s):  
Lidia C. Serra ◽  
Laura J. York ◽  
Paul Balmer ◽  
Chris Webber
Keyword(s):  
Conjugate Vaccine ◽  
Clinical Data ◽  
Tetanus Toxoid ◽  
Meningococcal Group ◽  
Group A
Sign in / Sign up

Export Citation Format

Share Document