scholarly journals Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 ◽  
Vol 16 (11) ◽  
pp. 1643-1656 ◽  
Author(s):  
Haruhiko Yagi ◽  
Takashi Nomura ◽  
Kyoko Nakamura ◽  
Sayuri Yamazaki ◽  
Toshio Kitawaki ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Crucial Role ◽  
And Function

scholarly journals A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke

Theranostics ◽  
2017 ◽  
Vol 7 (4) ◽  
pp. 855-875 ◽  
Author(s):  
Hsu-Tung Lee ◽  
Shih-Ping Liu ◽  
Chen-Huan Lin ◽  
Sophie Wei Lee ◽  
Chung Y. Hsu ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Crucial Role

scholarly journals The Role of Different Subsets of Regulatory T Cells in Immunopathogenesis of Rheumatoid Arthritis

Arthritis ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Maryam Gol-Ara ◽  
Farhad Jadidi-Niaragh ◽  
Reza Sadria ◽  
Gholamreza Azizi ◽  
Abbas Mirshafiey
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Regulatory T Cells ◽  
Joint Inflammation ◽  
Frequency Function ◽  
Systemic Inflammatory Disease ◽  
Progression Of Disease ◽  
Cartilage Erosion ◽  
And Function

Rheumatoid arthritis (RA) is a common autoimmune disease and a systemic inflammatory disease which is characterized by chronic joint inflammation and variable degrees of bone and cartilage erosion and hyperplasia of synovial tissues. Considering the role of autoreactive T cells (particularly Th1 and Th17 cells) in pathophysiology of RA, it might be assumed that the regulatory T cells (Tregs) will be able to control the initiation and progression of disease. The frequency, function, and properties of various subsets of Tregs including natural Tregs (nTregs), IL-10-producing type 1 Tregs (Tr1 cells), TGF-β-producing Th3 cells, CD8+ Tregs, and NKT regulatory cells have been investigated in various studies associated with RA and collagen-induced arthritis (CIA) as experimental model of this disease. In this paper, we intend to submit the comprehensive information about the immunobiology of various subsets of Tregs and their roles and function in immunopathophysiology of RA and its animal model, CIA.

scholarly journals Regulatory T Cells-Related Genes Are under DNA Methylation Influence

2021 ◽  
Vol 22 (13) ◽  
pp. 7144
Author(s):  
Magdalena Piotrowska ◽  
Mateusz Gliwiński ◽  
Piotr Trzonkowski ◽  
Dorota Iwaszkiewicz-Grzes
Keyword(s):  
Dna Methylation ◽  
T Cells ◽  
Regulatory T Cells ◽  
Methylation Status ◽  
Methylation Pattern ◽  
Epigenetic Changes ◽  
Epigenetic Modifiers ◽  
Repressive Mark ◽  
And Function

Regulatory T cells (Tregs) exert a highly suppressive function in the immune system. Disturbances in their function predispose an individual to autoimmune dysregulation, with a predominance of the pro-inflammatory environment. Besides Foxp3, which is a master regulator of these cells, other genes (e.g., Il2ra, Ctla4, Tnfrsf18, Ikzf2, and Ikzf4) are also involved in Tregs development and function. Multidimensional Tregs suppression is determined by factors that are believed to be crucial in the action of Tregs-related genes. Among them, epigenetic changes, such as DNA methylation, tend to be widely studied over the past few years. DNA methylation acts as a repressive mark, leading to diminished gene expression. Given the role of increased CpG methylation upon Tregs imprinting and functional stability, alterations in the methylation pattern can cause an imbalance in the immune response. Due to the fact that epigenetic changes can be reversible, so-called epigenetic modifiers are broadly used in order to improve Tregs performance. In this review, we place emphasis on the role of DNA methylation of the genes that are key regulators of Tregs function. We also discuss disease settings that have an impact on the methylation status of Tregs and systematize the usefulness of epigenetic drugs as factors able to influence Tregs functions.

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