Comparative in vitro activity of ertapenem and 11 other antimicrobial agents against aerobic and anaerobic pathogens isolated from skin and soft tissue animal and human bite wound infections

ABSTRACT BMS-284756, a new des-fluoro(6) quinolone, was very active against 240 aerobic and 180 anaerobic isolates from bite victims. It inhibited 403 of 420 (96%) isolates, including those of Moraxella spp., CDC group EF-4, and Eikenella corrodens at ≤2 μg/ml and those of all Pasteurella spp. and Bergeyella zoohelcum at ≤0.015 μg/ml. Fusobacterium russii and 6 of 11 Fusobacterium nucleatum isolates of animal bite origin were resistant, but isolates of human bite origin were susceptible, which suggests that they were of a different subspecies.

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Comparative in vitro activity of faropenem and 11 other antimicrobial agents against 405 aerobic and anaerobic pathogens isolated from skin and soft tissue infections from animal and human bites

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/dkf139 ◽

2002 ◽

Vol 50 (3) ◽

pp. 411-420 ◽

Cited By ~ 21

Author(s):

E. J. C. Goldstein

Keyword(s):

Soft Tissue ◽

Antimicrobial Agents ◽

Vitro Activity ◽

Soft Tissue Infections ◽

In Vitro Activity ◽

Human Bites ◽

Aerobic And Anaerobic

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Comparative in vitro activity of ceftaroline, ceftaroline-avibactam, and other antimicrobial agents against aerobic and anaerobic bacteria cultured from infected diabetic foot wounds

Diagnostic Microbiology and Infectious Disease ◽

10.1016/j.diagmicrobio.2013.03.019 ◽

2013 ◽

Vol 76 (3) ◽

pp. 347-351 ◽

Cited By ~ 17

Author(s):

Ellie J.C. Goldstein ◽

Diane M. Citron ◽

C. Vreni Merriam ◽

Kerin L. Tyrrell

Keyword(s):

Diabetic Foot ◽

Antimicrobial Agents ◽

Anaerobic Bacteria ◽

Vitro Activity ◽

In Vitro Activity ◽

Aerobic And Anaerobic

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In vitro activity of Bay 12-8039, a new 8-methoxyquinolone, compared to the activities of 11 other oral antimicrobial agents against 390 aerobic and anaerobic bacteria isolated from human and animal bite wound skin and soft tissue infections in humans.

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.41.7.1552 ◽

1997 ◽

Vol 41 (7) ◽

pp. 1552-1557 ◽

Cited By ~ 48

Author(s):

E J Goldstein ◽

D M Citron ◽

M Hudspeth ◽

S Hunt Gerardo ◽

C V Merriam

Keyword(s):

Antimicrobial Agents ◽

Anaerobic Bacteria ◽

Fusobacterium Nucleatum ◽

Vitro Activity ◽

Penicillin G ◽

In Vitro Activity ◽

Bite Wound ◽

Amoxicillin Clavulanate ◽

Prevotella Species

The in vitro activity of Bay 12-8039, a new oral 8-methoxyquinolone, was compared to the activities of 11 other oral antimicrobial agents (ciprofloxacin, levofloxacin, ofloxacin, sparfloxacin, azithromycin, clarithromycin, amoxicillin clavulanate, penicillin, cefuroxime, cefpodoxime, and doxycycline) against 250 aerobic and 140 anaerobic bacteria recently isolated from animal and human bite wound infections. Bay 12-8039 was active against all aerobic isolates, both gram-positive and gram-negative isolates, at < or = 1.0 microg/ml (MICs at which 90% of isolates are inhibited [MIC90s < or = 0.25 microg/ml) and was active against most anaerobes at < or = 0.5 microg/ml; the exceptions were Fusobacterium nucleatum and other Fusobacterium species (MIC90s, > or = 4.0 microg/ml) and one strain of Prevotella loeschii (MICs, 2.0 microg/ml). In comparison, the other quinolones tested had similar in vitro activities against the aerobic strains but were less active against the anaerobes, including peptostreptococci, Porphyromonas species, and Prevotella species. The fusobacteria were relatively resistant to all the antimicrobial agents tested except penicillin G (one penicillinase-producing strain of F. nucleatum was found) and amoxicillin clavulanate.

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