scholarly journals The tetracycline resistance determinant Tet 39 and the sulphonamide resistance gene sulII are common among resistant Acinetobacter spp. isolated from integrated fish farms in Thailand

2006 ◽  
Vol 59 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Y. Agerso ◽  
A. Petersen
Keyword(s):  
Resistance Gene ◽  
Tetracycline Resistance ◽  
Resistance Determinant ◽  
Fish Farms ◽  
Acinetobacter Spp

scholarly journals Novel Tetracycline Resistance Determinant from the Oral Metagenome

2003 ◽  
Vol 47 (4) ◽  
pp. 1430-1432 ◽  
Author(s):  
M. L. Diaz-Torres ◽  
R. McNab ◽  
D. A. Spratt ◽  
A. Villedieu ◽  
N. Hunt ◽  
...  
Keyword(s):  
Resistance Gene ◽  
Tetracycline Resistance ◽  
Resistance Determinant ◽  
Tetracycline Resistance Gene ◽  
Major Drawback

ABSTRACT A major drawback of most studies on how bacteria become resistant to antibiotics is that they concentrate mainly on bacteria that can be cultivated in the laboratory. In the present study, we cloned part of the oral metagenome and isolated a novel tetracycline resistance gene, tet(37), which inactivates tetracycline.

scholarly journals An IS257-Derived Hybrid Promoter Directs Transcription of a tetA(K) Tetracycline Resistance Gene in theStaphylococcus aureus Chromosomal mecRegion

2000 ◽  
Vol 182 (12) ◽  
pp. 3345-3352 ◽  
Author(s):  
Alice E. Simpson ◽  
Ronald A. Skurray ◽  
Neville Firth
Keyword(s):  
Staphylococcus Aureus ◽  
Resistance Gene ◽  
Gene Dosage ◽  
Tetracycline Resistance ◽  
Resistance Determinant ◽  
Tetracycline Resistance Gene ◽  
Methicillin Resistant ◽  
Hybrid Promoter ◽  
Genetic Rearrangements

ABSTRACT Transcription of the tetA(K) tetracycline resistance determinant encoded by an IS257-flanked cointegrated copy of a pT181-like plasmid, located within the chromosomal mecregion of a methicillin-resistant Staphylococcus aureusisolate, has been investigated. The results demonstrated that transcription of tetA(K) in this strain is directed by both an IS257-derived hybrid promoter, which is stronger than the native tetA(K) promoter in the autonomous form of pT181, and a complete outwardly directed promoter identified within one end of IS257. Despite lower gene dosage, the chromosomal configuration was shown to afford a higher level of resistance than that mediated by pT181 in an autonomous multicopy state. Furthermore, competition studies revealed that a strain carrying the chromosomaltetA(K) determinant exhibited a higher level of fitness in the presence of tetracycline but not in its absence. This finding suggests that tetracycline has been a selective factor in the emergence of strains carrying a cointegrated pT181-like plasmid in their chromosomes. The results highlight the potential of IS257to influence the expression of neighboring genes, a property likely to enhance its capacity to mediate advantageous genetic rearrangements.

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