Determination of Menthol in Cigarette Tobacco Filler

1968 ◽  
Vol 51 (3) ◽  
pp. 650-653
Author(s):  
Charles L Tucker
Keyword(s):  
Chromatographic Method ◽  
Colorimetric Method ◽  
Cigarette Tobacco ◽  
Mean Values ◽  
Gas Chromatographic Method ◽  
Colorimetric Procedure

Abstract A gas chromatographic method and two variations of a colorimetric method for determining menthol in cigarette tobacco filler were studied collaboratively by 13 laboratories. No statistically significant differences were found in the precisions within or between laboratories. There were no significant differences between means for any two of the three methods for any sample. A trend toward higher mean values was noted for both colorimetric procedures. The colorimetric procedure that uses a nonmentholated tobacco blank gave mean values nearest to those obtained by the gas chromatographic method. It is recommended that both the gas chromatographic method and the colorimetric method that uses the nonmentholated tobacco blank be adopted as official, first action

Determination of Menthol in Cigarette Tobacco Filler

1967 ◽  
Vol 50 (4) ◽  
pp. 770-773
Author(s):  
Charles L Tucker ◽  
C L Ogg
Keyword(s):  
Chromatographic Method ◽  
Colorimetric Method ◽  
Cigarette Tobacco ◽  
Mean Values ◽  
Accuracy And Precision ◽  
Standard Deviations ◽  
Gas Chromatographic Method

Abstract A gas chromatographic and a colorimetric method for determining menthol in cigarette tobacco filler were studied collaboratively by 15 laboratories. No statistically significant differences were found in the precisions within or between laboratories. There were no significant differences between mean values for the two methods for any of the samples. Trends toward higher mean values for the colorimetric method and lower within-laboratory standard deviations for the gas chromatographic method were noted. Remarks by collaborators suggest that the accuracy and precision of the colorimetric method may be improved, and further studies are recommended.

The Determination of Thiodan and Thiodan Sulphate on Tobacco and in Smoke Condensate

1971 ◽  
Vol 6 (2) ◽  
Author(s):  
H. Hengy ◽  
J. Thirion
Keyword(s):  
Quantitative Determination ◽  
Transfer Rate ◽  
Chromatographic Method ◽  
Mainstream Smoke ◽  
Cigarette Tobacco ◽  
Sulphate Content ◽  
Gas Chromatographic Method

AbstractA gas chromatographic method was developed for the quantitative determination of a- and b-thiodan and thiodan sulphate on tobacco and in smoke condensate in concentrations as Iow as 0.01 parts per million. A survey was made of the thiodan and thiodan sulphate content of leaf tobacco and cigarettes. Thiodan and thiodan sulphate residues in leaf tobacco were found to amount to between 0.02 and 0.3 ppm and to between less than 0.02 and 0.05 ppm respectively. Cigarettes manufactured from Virginia tobacco were found to contain between 0.1 and 0.2 ppm of thiodan and less than 0.05 ppm of thiodan sulphate. The transfer rate of thiodan and thiodan sulphate from cigarette tobacco into the mainstream smoke ranged from 14.5 % to 16.3 %

Analysis of Imidan Colorimetrically and by Electron-Affinity Gas Chromatography

1965 ◽  
Vol 48 (5) ◽  
pp. 922-926
Author(s):  
Malcolm C Bowman ◽  
Morton Beroza
Keyword(s):  
Gas Chromatography ◽  
Electron Affinity ◽  
Chromatographic Method ◽  
Sweet Corn ◽  
Chromotropic Acid ◽  
Hydrolytic Cleavage ◽  
Corn Plants ◽  
Gas Chromatographic Method ◽  
Colorimetric Procedure

Abstract A procedure for analyzing Imidan® colorimetrically is based on the acid hydrolytic cleavage of formaldehyde from the molecule and the determination of the liberated formaldehyde with chromotropic acid by the Eegriwe reaction. Recoveries of the pesticide from milk ranged from 75 to 88% in the 0.5–5.0 ppm range. A gas chromatographic method, also devised, required less cleanup and was faster, more accurate, more sensitive, and more specific than the colorimetric procedure. Recoveries of Imidan from milk at levels of 0.01–5 ppm ranged from 93 to 101% ; from whole sweet corn plants recoveries at levels of 0.05–10.0 ppm were from 94 to 106%.

Quantitative gas-chromatographic flame-ionization method for chloramphenicol in human serum.

1977 ◽  
Vol 23 (2) ◽  
pp. 220-222 ◽  
Author(s):  
C J Least ◽  
N J Wiegand ◽  
G F Johnson ◽  
H M Solomon
Keyword(s):  
Chromatographic Method ◽  
Internal Standard ◽  
Therapeutic Monitoring ◽  
Flame Ionization ◽  
Ionization Method ◽  
Chromatographic Procedure ◽  
Gas Chromatographic Method ◽  
Colorimetric Procedure ◽  
Microbiological Procedures

Abstract We describe a flame-ionization gas-chromatographic procedure for determination of the potentially toxic antibiotic, chloramphenical, in serum. The serum (500 mul) is extracted into ethyl acetate and nonpolar impurities are subsequently partitioned into hexane. The drug is chromatographed as its bis-trimethylsilyl derivative, with the analog thiamphenicol as the internal standard. Within-run precision (CV) is 4.4% at a serum concentration of 41 mg/liter and 9.2% at a concentration of 5 mg/liter. Over a six-month period, the run-to-run variation was 5.1% at 40 mg/liter (n = 24). Results by the gas-chromatographic method compared well with those by an established colorimetric procedure; mean concentrations for the comparison samples in the two procedures were 18.4 mg/liter and 17.6 mg/liter, respectively (n = 27), with a coefficient of correlation of 0.998. The gas-chromatographic method is more precise and specific than classical microbiological procedures and is suitable for routine therapeutic monitoring of serum chloramphenicol concentrations.

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