Liquid Chromatographic Determination of Medroxyprogesterone Acetate in Tablets
1988 ◽
Vol 71
(3)
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pp. 528-530
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Keyword(s):
Abstract A reverse-phase liquid chromatographic method is described for the assay of medroxyprogesterone acetate in tablets. An octadecylsilane (C18) column with a mobile phase of methanol-O.OlM dibasic ammonium phosphate (80 + 20 v/v, pH 7.2 ± 0.1) and photometric detection at 254 nm separates medroxyprogesterone acetate from excipients. Detector responses were linear to concentrations of medroxyprogesterone acetate over the range 50-150 μg/mL (r = 0.999). Mean recovery of medroxyprogesterone acetate added to tablet excipients was 100.8%. Mean assay results were 101.3% (n = 3). The assay results are comparable to those obtained by the compendial liquid chromatographic method
1992 ◽
Vol 75
(1)
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pp. 62-65
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1989 ◽
Vol 72
(2)
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pp. 231-234
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1983 ◽
Vol 66
(4)
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pp. 909-912
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1995 ◽
Vol 78
(2)
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pp. 307-309
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1984 ◽
Vol 67
(2)
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pp. 225-227
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1997 ◽
Vol 80
(3)
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pp. 549-554
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