Determination of Ticarcillin and Clavulanic Acid in Serum by Liquid Chromatography
1992 ◽
Vol 75
(1)
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pp. 30-33
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Keyword(s):
Abstract A liquid chromatographic (LC) method using solidphase extraction for the determination of clavulanic acid and ticarcillin in human serum has been developed. Clavulanic acid and ticarcillin were extracted separately from 1 mL serum using C18 solid-phase extraction cartridges. Eluates were analyzed by the same reversed-phase LC system. The overall mean recovery of clavulanic acid from serum was 99.7 ±2.3%; the lowest level validated in serum was 0.5 μg/mL. The overall mean recovery of ticarcillin from serum was 101.5 ±3%; the lowest level validated in serum was 12.5 μg/mL. Detection limits for clavulanic acid and ticarcillin were 0.117 and 0.749 μg/mL, respectively.
2005 ◽
Vol 88
(3)
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pp. 679-683
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1993 ◽
Vol 16
(6)
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pp. 1297-1314
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2014 ◽
Vol 53
(2)
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pp. 210-218
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2001 ◽
Vol 69
(2)
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pp. 45-54
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2004 ◽
Vol 87
(4)
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pp. 937-942
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1999 ◽
Vol 82
(6)
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pp. 1345-1352
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1996 ◽
Vol 675
(2)
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pp. 295-302
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1992 ◽
Vol 14
(4)
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pp. 306-311
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