Development of a New Series of Agricultural/Food Reference Materials for Analytical Quality Control of Elemental Determinations

1994 ◽  
Vol 77 (6) ◽  
pp. 1605-1626 ◽  
Author(s):  
Milan Ihnat
Keyword(s):  
Quality Control ◽  
Elemental Composition ◽  
Wheat Flour ◽  
Reference Materials ◽  
Analytical Methods ◽  
Corn Starch ◽  
Analytical Data ◽  
Standard Reference Materials ◽  
Substantial Contribution ◽  
Agricultural Food

Abstract Ten new Agricultural/Food Reference Materials — Bovine Muscle Powder (National Institute of Standards and Technology [NIST], code NIST RM 8414), Whole Egg Powder (NIST RM 8415), Microcrystalline Cellulose (NIST RM 8416), Wheat Gluten (NIST RM 8418), Corn Starch (NIST RM 8432), Corn Bran (NIST RM 8433), Whole Milk Powder (NIST RM 8435), Durum Wheat Flour (NIST RM 8436), Hard Red Spring Wheat Flour (NIST RM 8437) and Soft Winter Wheat Flour (NIST RM 8438) — were prepared by application of milling, irradiation, sieving, blending, and packaging procedures. Excellent material homogeneity was found for virtually all major, minor, and trace elements of interest. The reference materials were characterized with respect to elemental composition via an extensive international, interlaboratory characterization (certification) campaign. Chemical analyses conducted in 73 cooperating laboratories applying 13 major classes of independently different analytical methods led to 278 concentration values for 34 nutritionally, toxicologically, and environmentally pertinent elements. A total of 213 best-estimate and 65 informational concentration values are available for Al, As, B, Ba, Br, Ca, Cd, CI, Co, Cr, Cs, Cu, F, Fe, Hg, I, K, Mg, Mn, Mo, N, Na, Ni, P, Pb, Rb, S, Sb, Se, Sr, Ti, V, W, and Zn. These products make a substantial contribution to the existing world repertoire of biological reference materials with respect to natural matrix and elemental composition. They are expected to be useful to analysts for quality control of analytical data. Applications include evaluations of analytical methods and instruments used in nutritional, toxicological, monitory, regulatory, environmental, agricultural, and other investigations. These products are available to the analytical community from the Standard Reference Materials Program, NIST, Gaithersburg, MD.

scholarly journals Development of the Analytical Methods and Reference Materials Program for Dietary Supplements at The National Institutes of Health

2004 ◽  
Vol 87 (1) ◽  
pp. 162-165 ◽  
Author(s):  
Leila G Saldanha ◽  
Joseph M Betz ◽  
Paul M Coates
Keyword(s):  
Quality Control ◽  
Dietary Supplements ◽  
Reference Materials ◽  
Analytical Methods ◽  
Research Agenda ◽  
Control Unit ◽  
Lessons Learned ◽  
National Institutes Of Health ◽  
Good Manufacturing Practices ◽  
The U.S

Abstract The need for validated analytical methods and reference materials to identify and measure constituents in dietary supplements is essential. Such methods allow for the documentation that products meet manufacturer's specifications and contain what their labels declare. In March 2003, the U.S. Food and Drug Administration issued a proposed rule that would establish specific current good manufacturing practices for dietary supplements. This proposed rule requires that companies create a quality control unit to set specifications and ensure compliance with these specifications using scientifically valid procedures. This report provides insights and lessons learned from 3 meetings the Office of Dietary Supplements (ODS) at the National Institutes of Health helped organize. These meetings were structured to (1) educate individuals about the importance and need for validated analytical methods and reference materials to identify and quantify constituents of dietary supplements; (2) identify resources required to fulfill this need; and (3) serve as a platform to obtain input from interested parties to help frame the research agenda for the Dietary Supplements Methods and Reference Materials Program within ODS. Stakeholder's opinions and views expressed at these 3 meetings are outlined in this report.

scholarly journals Standard Reference Materials for Analysis of Dietary Supplements

2008 ◽  
Vol 91 (6) ◽  
pp. 1298-1302 ◽  
Author(s):  
Katherine E Sharpless ◽  
David L Duewer
Keyword(s):  
Quality Control ◽  
Dietary Supplements ◽  
Method Validation ◽  
Drug Administration ◽  
Reference Materials ◽  
Food And Drug Administration ◽  
Standard Reference Materials ◽  
Quality Control Materials ◽  
The U.S

Abstract National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of HealthOffice of Dietary Supplements and the U.S. Food and Drug Administration, is producing Standard Reference Materials (SRMs) for dietary supplements. These and other natural-matrix SRMs should be used in method validation, characterization of in-house quality control materials, and to establish traceability.

scholarly journals Modern Analytical Facilities 2. A Review of Quality Assurance and Quality Control (QA/QC) Procedures for Lithogeochemical Data

2014 ◽  
Vol 41 (1) ◽  
pp. 75 ◽  
Author(s):  
Stephen J. Piercey
Keyword(s):  
Quality Control ◽  
Quality Assurance ◽  
Reference Materials ◽  
Control Charts ◽  
Statistical Tests ◽  
Analytical Data ◽  
Relative Difference ◽  
T Test ◽  
Relative Standard ◽  
Modern Analytical

Quality assurance and quality control (QA/QC) are critical components of modern analytical geochemistry.  A properly constructed QA/QC program identifies both the source of analytical error and provides a means of establishing confidence in and assessing limitations of analytical data. A QA/QC program involves monitoring precision, accuracy, and potential contamination from sampling to analysis.  Precision can be monitored via the systematic insertion of sample, pulp, and analytical duplicates, and reference materials; the resulting data are subsequently evaluated using scatterplots, statistical tests (e.g. % relative standard deviation), Thompson-Howarth plots, and the average coefficient of variation (CVavg (%)).  Accuracy is determined through the submission of reference materials and monitored using statistical tests (e.g. % relative difference, t-test) and Shewart control charts.   Blanks test contamination and results are monitored using Shewart control charts.SOMMAIREL'assurance de la qualité et le contrôle de la qualité (AQ-CQ) sont deux composantes essentielles à la géochimie analytique moderne.  Un programme AQ-CQ bien conçu défini à la fois la source de l'erreur d'analyse et un moyen d'établir la confiance et d’évaluer les limites des données analytiques.  Un programme AQ-CQ comprend le contrôle de la précision, de l'exactitude et de la contamination potentielle, de l'étape d’échantillonnage à l'analyse.  La précision peut être contrôlée via l'insertion systématique d'échantillon, de pulpes, et de doublons d'analyse, et de matériaux de référence; les données obtenues sont ensuite évaluées en utilisant des diagrammes de dispersion, des tests statistiques (pourcentage d’écart type relatif, par ex.), des courbes de Thompson-Howarth, et des  coefficients de variation moyens (CVm %).  La précision est déterminée par la soumission de documents de référence et de contrôle par des tests statistiques (différence relative en %, t-test, par ex.) et des graphiques de contrôle de Shewhart.  La contamination d’essais à blanc et les résultats sont contrôlés par des graphiques de contrôle Shewhart.

National Bureau of Standards Reference Materials as Organic Nutrient Standards: A Preliminary Study

1985 ◽  
Vol 68 (6) ◽  
pp. 1084-1086
Author(s):  
James T Tanner ◽  
Jeffrey S Smith ◽  
Gerald Angyal ◽  
Phillip W Defibaugh ◽  
Melina C Villalobos ◽  
...  
Keyword(s):  
Wheat Flour ◽  
Reference Materials ◽  
Vitamin B6 ◽  
Rice Flour ◽  
Standard Reference Materials ◽  
National Bureau ◽  
Oyster Tissue ◽  
Powdered Milk ◽  
Organic Nutrient ◽  
Preliminary Study

Abstract A preliminary study was conducted to determine if the available National Bureau of Standards (NBS) Standard Reference Materials (SRM) Non- Fat Powdered Milk, Oyster Tissue, Wheat Flour, Rice Flour, Spinach, and Albacore Tuna would be suitable for use as organic nutrient standards. These materials were assayed for folates, total pantothenates, vitamin B6, thiamine, riboflavin, niacin, and protein. Vitamins A, E, D, K, and C were also assayed but, for the most part, were not detected. Based on results from this study, it appears that at least some of the NBS SRMs would be useful as organic nutrient standards.

International Survey on Dietary Fiber: Definition, Analysis, and Reference Materials

1995 ◽  
Vol 78 (1) ◽  
pp. 22-36 ◽  
Author(s):  
Sungsoo C Lee ◽  
Leon Prosky
Keyword(s):  
Quality Control ◽  
Liquid Chromatography ◽  
Dietary Fiber ◽  
Reference Materials ◽  
Analytical Methods ◽  
Gas Liquid Chromatography ◽  
Nutrition Labeling ◽  
International Survey ◽  
Total Dietary Fiber ◽  
Nutrition Research

Abstract An international survey was conducted to get the views of 147 professionals in the field on the definition of dietary fiber. The survey also solicited opinions on analytical methods for nutrition labeling, quality control, and nutrition research. The survey finds that dietary fiber is generally defined as polysaccharides and lignin that are not hydrolyzed by human alimentary enzymes. Support is strong for expansion of the definition to include oligosaccharides that are resistant to hydrolysis by human alimentary enzymes. Among techniques for nutrition labeling and quality control, enzymatic-gravimetric methods get the highest support. For nutrition research, more detailed methods such as gas-liquid chromatography and liquid chromatography were considered more appropriate. Respondents support labeling of total, soluble, and insoluble dietary fiber or total dietary fiber alone as sufficient for nutrition labeling of food packages. However, for nutrition research, detailed analytical methods, improvements in accuracy (i.e., closer simulation of in vitro techniques to conditions of human gastrointestinal tract), and improvements in precision and simplicity are suggested. Less than 20% of the participants use reference materials for dietary fiber analysis.

NBS Plant Tissue Standard Reference Materials

1980 ◽  
Vol 63 (4) ◽  
pp. 806-808
Author(s):  
Robert Alvarez
Keyword(s):  
Reference Materials ◽  
Analytical Methods ◽  
Rice Flour ◽  
Accurate Method ◽  
Powdered Material ◽  
Reference Points ◽  
Standard Reference Materials ◽  
Common Reference ◽  
Definitive Method ◽  
Certified Values

Abstract NBS issues 6 Standard Reference Materials for use in determining nutrient and contaminant elements in plant tissues and agricultural food products. They are SRM 1571, Orchard Leaves; SRM 1573, Tomato Leaves; SRM 1575, Pine Needles; SRM 1570, Spinach; SRM 1567, Wheat Flour; and SRM 1568, Rice Flour. These SRMs are used to calibrate instrumentation, to determine accuracy of existing analytical methods, and to develop more accurate methods. The Certificate of Analysis for each SRM details the homogeneity of the powdered material, the minimum sample size to be used, the certified values for the elements with their uncertainties, and the noncertified values. A certified value is based either on concordant results by independent analytical methods or on results by a definitive method, i.e., an accurate method having identified, systematic errors. These certified values can serve as common reference points for comparison of data acquired over a long period by various investigators using a variety of methods.

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