scholarly journals Spectrophotometric Determination of Some Hydrazine Derivatives Using 2,3-Dichloro-5,6-Dicyano-p-Benzoquinone

1999 ◽  
Vol 82 (2) ◽  
pp. 239-243 ◽  
Author(s):  
Sheikha Mohamed Al-Ghannam ◽  
Amina Mohamed El-Brashy ◽  
Laila Abdel-Rahman Al-Hussein
Keyword(s):  
Charge Transfer ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Pharmaceutical Formulations ◽  
Charge Transfer Complexes ◽  
Hydrazine Derivatives ◽  
Unit Dose ◽  
The Individual

Abstract A simple, sensitive, and rapid spectrophotometric method for determining isoniazid, isocarboxazid, and iproniazid phosphate is described. In this method, 2,3-dichloro-5,6-dicyano-p-benzoquinone (a π-acceptor) is used to form charge-transfer complexes with cited drugs (n-donors). The procedure is sensitive enough to permit unit dose assay of the individual drugs in their pharmaceutical formulations. The assay results are in accord with the pharmacopoeial assay results.

scholarly journals Sensitive Spectrophotometric Determinations of Paracetamol and Protriptyline HCl Using 3-Chloro-7-hydroxy-4-methyl-2H-chromen-2-one

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Kumble Divya ◽  
Badiadka Narayana ◽  
Majal Sapnakumari
Keyword(s):  
Charge Transfer ◽  
Spectrophotometric Method ◽  
Charge Transfer Complex ◽  
Limit Of Detection ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Pharmaceutical Samples ◽  
Chromogenic Reagent ◽  
Detection And Quantification

A new spectrophotometric method is developed for the determination of Paracetamol (PCT) and protriptyline HCl (PTP) in pure forms and in pharmaceutical formulations. The experiment involves the use of 3-chloro-7-hydroxy-4-methyl-2H-chromen-2-one as a novel chromogenic reagent for the determination of PCT and PTP. The method is based on the formation of charge transfer complex between the drugs and chromogenic reagent. Beer's law is obeyed in the concentration ranges 10.00–60.00 µg mL−1 for PCT at 545 nm and 40.00–160.00 µg mL−1 for PTP at 468 nm. The molar absorptivity, Sandell, sensitivity, and limit of detection and quantification are also calculated. The method has been successfully applied for the determination of both PCT and PTP in pharmaceutical samples with acceptable results.

scholarly journals The Use of 7,7′,8,8′-Tetracyanoquinodimethane for the Spectrophotometric Determination of Some Primary Amines Application to Real Water Samples

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Theia'a N. Al-Sabha ◽  
Najwa M. Al-Karemy
Keyword(s):  
Charge Transfer ◽  
Quantitative Determination ◽  
Spectrophotometric Method ◽  
Aromatic Amines ◽  
Molar Absorptivity ◽  
Primary Amines ◽  
Charge Transfer Complexes ◽  
Buffer Solution ◽  
Real Water Samples

A sensitive, simple, and accurate spectrophotometric method was developed for the quantitative determination of some primary aliphatic and aromatic amines, that is, ethylamine, 1,2-diaminopropane, aniline, p-aminophenol, and benzidine. The method is based on the interaction of these amines in aqueous medium with 7,7′,8,8′-tetracyanoquinodimethane (TCNQ) reagent in the presence of a buffer solution and surfactant (in the case of aromatic amines) to form charge-transfer complexes measurable at maximum wavelengths ranging between 323 and 511 nm. Beer’s law is obeyed over the concentration ranges of 0.025 and 3.0 μg/mL and the molar absorptivity is ranged between 8.977 × 103and 5.8034 × 104 L·mol−1·cm−1for these amines. The method was applied for the determination of benzidine in the river, sea, and tap waters. The TCNQ complexes with the previously mentioned amines were formed in the ratio of 1 : 1 amine : TCNQ, and their stability constants ranged between 8.78 × 104and 1.844 × 105 L·mol−1.

scholarly journals Spectrophotometric Determination of Some Antihistaminic Drugs Using 7,7,8,8-Tetracyanoquinodimethane (TCNQ)

2006 ◽  
Vol 89 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Amr M Badawey ◽  
Samah S Abbas ◽  
Hayam M Loutfy
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Good Accuracy ◽  
Pharmaceutical Formulations ◽  
European Pharmacopoeia ◽  
Accuracy And Precision ◽  
Antihistaminic Drugs ◽  
Assay Conditions ◽  
Sensitive Spectrophotometric Method

Abstract A simple and sensitive spectrophotometric method is suggested for analysis of 3 antihistaminic drugs, acrivastine (I), mequitazine (II), and dimethindene maleate (III). The method is based on reaction of the drugs with 7,7,8,8-tetracyanoquinodimethane (TCNQ) in acetonitrile to form highly stable colored products that are measured at 750, 766, and 844 nm for I and II, and 480 and 618 nm for III. Beer's law is obeyed in the ranges of 560 g/mL for I, 550 g/mL for II, and 1070 g/mL for III. The optimum assay conditions and their applicability to the determination of the cited drugs in pharmaceutical formulations are described. The method is statistically analyzed as compared with the European Pharmacopoeia (2001) method for the analysis of dimethindene maleate and reference methods for acrivastine and mequitazine drugs revealing good accuracy and precision.

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