scholarly journals Retinoic Acid Increases Cellular Retinol Binding Protein II mRNA and Retinol Uptake in the Human Intestinal Caco-2 Cell Line

1997 ◽  
Vol 127 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Marc S. Levin ◽  
Alan E. Davis
Keyword(s):  
Retinoic Acid ◽  
Cell Line ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Cellular Retinol Binding Protein

scholarly journals Retinol bound to cellular retinol-binding protein is a substrate for cytosolic retinoic acid synthesis.

1993 ◽  
Vol 268 (36) ◽  
pp. 27133-27142
Author(s):  
S Ottonello ◽  
G Scita ◽  
G Mantovani ◽  
D Cavazzini ◽  
G L Rossi
Keyword(s):  
Retinoic Acid ◽  
Binding Protein ◽  
Acid Synthesis ◽  
Retinol Binding Protein ◽  
Cellular Retinol Binding Protein

Analysis of human cellular retinol-binding protein II promoter during enterocyte differentiation

2002 ◽  
Vol 282 (6) ◽  
pp. G1079-G1087 ◽  
Author(s):  
Liang Zhang ◽  
Xueping E ◽  
Kathryn E. Luker ◽  
Jian-Su Shao ◽  
Marc S. Levin ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Direct Sequence Analysis ◽  
Selective Agonists ◽  
Flanking Region ◽  
Small Intestinal ◽  
Small Intestinal Villus ◽  
Enterocyte Differentiation ◽  
Cellular Retinol Binding Protein

Cellular retinol binding protein II (CRBP II) is a vitamin A-binding protein that is expressed specifically in small intestinal villus absorptive cells. Previous studies have shown that retinoic acid upregulates endogenous human CRBP II gene expression in differentiated Caco-2 cells. To better characterize the regulation of human CRBP II expression, we analyzed the ability of receptor-selective agonists to enhance transcription from the 5′-upstream flanking region of the human CRBP II gene. Stable transfection experiments showed that the proximal 2.8-kb region of the human CRBP II gene is sufficient for retinoic acid inducibility in differentiated Caco-2 cells. However, direct sequence analysis and transient transfection experiments indicate that, unlike the rat CRBP II promoter, the human CRBP II promoter is not a direct retinoid X receptor target. The results indicate that the retinoic acid responsiveness of the human CRBP II promoter is mediated by an indirect mechanism and that this mechanism is associated with enterocyte differentiation.

scholarly journals Cellular Retinol-binding Protein-supported Retinoic Acid Synthesis

1996 ◽  
Vol 271 (10) ◽  
pp. 5610-5616 ◽  
Author(s):  
Manja H. E. M. Boerman ◽  
Joseph L. Napoli
Keyword(s):  
Retinoic Acid ◽  
Binding Protein ◽  
Acid Synthesis ◽  
Retinol Binding Protein ◽  
Cellular Retinol Binding Protein

scholarly journals All-Trans Retinoic Acid Induces Cellular Retinol-Binding Protein in Human Skin In Vivo

1995 ◽  
Vol 105 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Gary J. Fisher ◽  
Ambati P. Reddy ◽  
Subhash C. Datta ◽  
Sewon Kang ◽  
Jong Y. Yi ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Human Skin ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Cellular Retinol Binding Protein
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