scholarly journals Cellular retinol-binding protein-I inhibits PI3K/Akt signaling through a retinoic acid receptor-dependent mechanism that regulates p85–p110 heterodimerization

Oncogene ◽  
2004 ◽  
Vol 24 (9) ◽  
pp. 1598-1606 ◽  
Author(s):  
Eduardo F Farias ◽  
Chistine Marzan ◽  
Rafael Mira-y-Lopez
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Binding Protein ◽  
Akt Signaling ◽  
Retinol Binding Protein ◽  
Acid Receptor ◽  
Cellular Retinol Binding Protein ◽  
Dependent Mechanism

Analysis of human cellular retinol-binding protein II promoter during enterocyte differentiation

2002 ◽  
Vol 282 (6) ◽  
pp. G1079-G1087 ◽  
Author(s):  
Liang Zhang ◽  
Xueping E ◽  
Kathryn E. Luker ◽  
Jian-Su Shao ◽  
Marc S. Levin ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Direct Sequence Analysis ◽  
Selective Agonists ◽  
Flanking Region ◽  
Small Intestinal ◽  
Small Intestinal Villus ◽  
Enterocyte Differentiation ◽  
Cellular Retinol Binding Protein

Cellular retinol binding protein II (CRBP II) is a vitamin A-binding protein that is expressed specifically in small intestinal villus absorptive cells. Previous studies have shown that retinoic acid upregulates endogenous human CRBP II gene expression in differentiated Caco-2 cells. To better characterize the regulation of human CRBP II expression, we analyzed the ability of receptor-selective agonists to enhance transcription from the 5′-upstream flanking region of the human CRBP II gene. Stable transfection experiments showed that the proximal 2.8-kb region of the human CRBP II gene is sufficient for retinoic acid inducibility in differentiated Caco-2 cells. However, direct sequence analysis and transient transfection experiments indicate that, unlike the rat CRBP II promoter, the human CRBP II promoter is not a direct retinoid X receptor target. The results indicate that the retinoic acid responsiveness of the human CRBP II promoter is mediated by an indirect mechanism and that this mechanism is associated with enterocyte differentiation.

Retinoic Acid Receptor, Cytosolic Retinol-Binding and Retinoic Acid-Binding Protein mRNA Transcripts and Proteins in Rat Insulin-Secreting Cells

Diabetes ◽  
1993 ◽  
Vol 42 (8) ◽  
pp. 1109-1114 ◽  
Author(s):  
B. S. Chertow ◽  
W. S. Blaner ◽  
N. Rajan ◽  
D. A. Primerano ◽  
P. Meda ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Binding Protein ◽  
Acid Receptor ◽  
Acid Binding Protein ◽  
Mrna Transcripts ◽  
Insulin Secreting Cells
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