Primary squamous cell carcinoma of the thyroid gland

Primary squamous cell carcinoma of thyroid is a very rare malignant tumor with poor prognosis. It is usually diagnosed as an advanced disease infiltrating adjacent organs, and characterized by aggressive clinical course with an average postoperative survival time of less than 1 year. Recently, we had a 79- year-old woman with a painful neck mass who was diagnosed as primary squamous cell carcinoma of thyroid gland. She underwent total thyroidectomy and selective neck dissection(level Ⅲ, Ⅵ) with no further postoperative managements such as radiation therapy or chemotherapy; she died of poor general condition and pneumonia resulting from rapid progression of the lesion on the 38th day after surgery. We report this case with a review of relevant literatures.

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Primary squamous cell carcinoma of the thyroid-case report of a rare disease

Endocrinology and Disorders ◽

10.31579/2640-1045/057 ◽

2020 ◽

Vol 4 (2) ◽

pp. 01-04

Author(s):

Lévay Bernadett

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Thyroid Gland ◽

Cell Carcinoma ◽

Squamous Cell ◽

Vocal Cord Palsy ◽

Neck Mass ◽

Primary Squamous Cell Carcinoma ◽

Adequate Treatment ◽

Disease Case

Introduction: Primary squamous cell carcinoma (SCC) of the thyroid gland is a very rare entity. The prognosis is very poor with a short survival time. The aim of this article is to report a case of a SCC of the thyroid gland in a 68-year-old woman, emphasizing how complicate is the operation and the adequate treatment of this disease. Case Report: A 68-year -old woman presented with rapidly growing neck mass with hoarseness and compressive symptoms. Physical examination revealed a hard fixed tumor with right sided vocal cord palsy. Histopathological result confirmed the diagnosis of SCC of the thyroid. PET/CT scan excluded the possibility of other primary malignancies. A surgical intervention was performed, however the patient died in the middle of the palliative radiation therapy. Conclusion: SCC of the thyroid gland is a great challenge for the surgeon and also for the multidisciplinary team to come up with the best treatment option which is suitable for the patient due to its unfavorable prognosis.

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The Utility of Immunohistochemistry in Differentiating Metastatic Primary Squamous Cell Carcinoma of the Thyroid from a Primary Lung Squamous Cell Carcinoma

Case Reports in Endocrinology ◽

10.1155/2019/8641267 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Nern Hoong Kao ◽

Chien Sheng Tan ◽

Adrian Jit Hin Koh

Keyword(s):

Squamous Cell Carcinoma ◽

Thyroid Gland ◽

Cell Carcinoma ◽

Squamous Cell ◽

Primary Tumour ◽

Lung Squamous Cell Carcinoma ◽

Anaplastic Thyroid Carcinoma ◽

Primary Site ◽

Primary Squamous Cell Carcinoma ◽

Diagnostic Challenge

Primary squamous cell carcinoma of the thyroid gland (PSCCTh) and anaplastic thyroid carcinoma with extensive squamous differentiation are rare entities which pose a diagnostic challenge in determining the primary site when presented as metastases. The difficulty in confirming a thyroid primary is further compounded by the aggressive nature of these tumours which frequently present at advanced stages. We present a case in which the patient presented with a thyroid mass and a lung mass simultaneously. The risk of misinterpreting the site of primary tumour as lung is greatly increased because squamous cell carcinoma of lung is much more common than its thyroid counterpart. This case highlights the effectiveness of PAX-8 stain in determining the primary site of tumour when squamous cell carcinoma is found in both lung and thyroid gland.

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