Malignant tumours, pericardial tumours, and therapy

ESC CardioMed ◽  
2018 ◽  
pp. 1617-1624
Author(s):  
Cristina Basso ◽  
Stefania Rizzo ◽  
Marialuisa Valente ◽  
Martina Perazzolo Marra ◽  
Gaetano Thiene

Primary malignant neoplasms account for 10% of all primary cardiac tumours and are represented by sarcomas (mainly angiosarcoma, undifferentiated pleomorphic sarcoma, leiomyosarcoma) and primary lymphomas. They usually infiltrate the cardiac walls, but may be also solely intracavitary, mimicking myxoma.

Author(s):  
Cristina Basso ◽  
Peter T Buser ◽  
Stefania Rizzo ◽  
Massimo Lombardi ◽  
Gaetano Thiene

In adult patients, sarcomas are the most frequently encountered primary cardiac malignant tumours, followed by lymphomas. Primary sarcomas of the heart form a group of tumours with variable differentiation and cell pleomorphism. According to histopathology, they are categorized as angiosarcomas, leiomyosarcomas, undifferentiated pleomorphic sarcoma, and myxofibrosarcomas. On cardiovascular magnetic resonance (CMR), most sarcomas appear extremely heterogeneous and usually cannot be differentiated from each other. Some cases with angiosarcomas can be identified by their specific appearance with early- and late-enhancement CMR. Some features of early- and late-enhancement CMR may argue for lymphoma, when discussing the differential diagnosis of a malignant primary cardiac mass.


2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Luca Restivo ◽  
Antonio De Luca ◽  
Matteo Castrichini ◽  
Alessandro Pierri ◽  
Elisabetta Rauber ◽  
...  

Abstract Aims Cardiac tumors are rare and heterogeneous entities which still remain a diagnostic and therapeutic challenge. The treatment for most cardiac tumors is prompt surgical resection. We sought to provide an overview of surgical results from a series of consecutive patients treated at our tertiary centre during almost a 20-year experience. Methods and results In this single centre study, 55 consecutive patients with cardiac tumor underwent surgical treatment from January 2002 to April 2021. Of these, 42% of patients were male and the mean age was 62 ± 12 years. Almost 27% of patients were symptomatic at the time of the diagnosis, mostly for dyspnoea and palpitations. The most frequent benign cardiac tumor was myxoma (58% of cases), occurring mainly in the left atrium (97%). Pleomorphic sarcoma was the most frequent primary malignant cardiac tumour (7.2% of cases), mainly located in the ventricles (25% left ventricle; 50% right ventricle). In all cases of benign tumors surgery was successful with no relapses. In 50% of cases of pleomorphic sarcoma relapses were observed during follow-up. After a median follow-up of 44 months, 15 (27%) patients died. While malignant tumors presented a limited survival, benign tumours showed a very good prognosis. Conclusions Cardiac tumours require a multidisciplinary work-up to guarantee a prompt diagnosis and appropriate treatment. In our surgical experience, the prognosis of benign tumours was excellent, while malignant tumours had poor outcomes despite radical surgery.


2017 ◽  
Vol 4 (2) ◽  
pp. 102-104
Author(s):  
Sunil Vitthalrao Jagtap ◽  
◽  
Cyrus Dara Jokhi ◽  
Swati S Jagtap ◽  
Ritvij Patankar ◽  
...  

Rare Tumors ◽  
2021 ◽  
Vol 13 ◽  
pp. 203636132110264
Author(s):  
Andrea Dekanić ◽  
Marko Velepič ◽  
Margita Belušić Gobić ◽  
Ita Hadžisejdić ◽  
Nives Jonjić

Malignant mesenchymal tumors of oropharyngeal mucosa are rare. Those with fibroblastic and histiocytic differentiation in the skin are called atypical fibroxanthoma (AFX) and in the soft tissue undifferentiated pleomorphic sarcoma (UPS). Here we present a case of an older patient with a history of multiple basal cell carcinomas and recently with a rapidly growing polypoid lesion in the mucosa of posterior oropharyngeal wall with AFX/UPS morphology. The differential diagnosis, histological pitfalls of this poorly characterized mesenchymal lesions, and the challenges associated with treatment are discussed.


2020 ◽  
Vol 18 (3) ◽  
Author(s):  
Amita Naithani ◽  
Parul Sharma ◽  
R. Pratima ◽  
Priyanka Makkar ◽  
Sunil Pasricha ◽  
...  

1970 ◽  
Vol 1 (2) ◽  
pp. 151-153 ◽  
Author(s):  
BM Amatya ◽  
M Sawabe ◽  
T Arai ◽  
T Kumakawa ◽  
K Takubo ◽  
...  

(The order of authors on this article was changed on 09/01/2012.)Primary undifferentiated pleomorphic sarcoma of the spleen is a rare and highly aggressive neoplasm that usually presents with splenomegaly, constitutional symptoms and frequent distant metastases. We report a case of 77-year old male patient with a past history of dissecting aortic aneurysm that developed acute hemorrhagic shock. Aneurysmal rupture was clinically suspected, but the postmortem examination revealed a 25 mm-sized tumor in an atrophic spleen weighing 65 gram with massive retroperitoneal bleeding. Metastases were found in the right renal hilus, the right adrenal gland and femoral bone marrow. Histology of the tumor showed undifferentiated pleomorphic sarcoma. Tumor rupture with fatal bleeding and systemic metastases had occurred despite the small size of the tumor. Tumor size is not a reliable predictor of systemic metastasis or tumor rupture for splenic undifferentiated pleomorphic sarcoma. Keywords: Undifferentiated pleomorphic sarcoma; Malignant fibrous histiocytoma; Splenic neoplasms; Retroperitoneal hemorrhage DOI: http://dx.doi.org/10.3126/jpn.v1i2.5411 JPN 2011; 1(2): 151-153


2018 ◽  
Vol 144 (4) ◽  
pp. 859-867 ◽  
Author(s):  
Martin F. Orth ◽  
Julia S. Gerke ◽  
Thomas Knösel ◽  
Annelore Altendorf-Hofmann ◽  
Julian Musa ◽  
...  

2007 ◽  
Vol 48 (1) ◽  
pp. 131 ◽  
Author(s):  
Sung-Hwan Suh ◽  
Tae-Ho Park ◽  
Jung-Nam Yoo ◽  
Kwang-Soo Cha ◽  
Moo-Hyun Kim ◽  
...  

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