scholarly journals 413 Challenges in the field of cardiac tumours: the surgical experience of Trieste

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Luca Restivo ◽  
Antonio De Luca ◽  
Matteo Castrichini ◽  
Alessandro Pierri ◽  
Elisabetta Rauber ◽  
...  
Keyword(s):  
Cardiac Tumor ◽  
Malignant Tumors ◽  
Benign Tumors ◽  
Cardiac Tumors ◽  
Malignant Tumours ◽  
Surgical Experience ◽  
Cardiac Tumours ◽  
Pleomorphic Sarcoma ◽  
Benign Tumours

Abstract Aims Cardiac tumors are rare and heterogeneous entities which still remain a diagnostic and therapeutic challenge. The treatment for most cardiac tumors is prompt surgical resection. We sought to provide an overview of surgical results from a series of consecutive patients treated at our tertiary centre during almost a 20-year experience. Methods and results In this single centre study, 55 consecutive patients with cardiac tumor underwent surgical treatment from January 2002 to April 2021. Of these, 42% of patients were male and the mean age was 62 ± 12 years. Almost 27% of patients were symptomatic at the time of the diagnosis, mostly for dyspnoea and palpitations. The most frequent benign cardiac tumor was myxoma (58% of cases), occurring mainly in the left atrium (97%). Pleomorphic sarcoma was the most frequent primary malignant cardiac tumour (7.2% of cases), mainly located in the ventricles (25% left ventricle; 50% right ventricle). In all cases of benign tumors surgery was successful with no relapses. In 50% of cases of pleomorphic sarcoma relapses were observed during follow-up. After a median follow-up of 44 months, 15 (27%) patients died. While malignant tumors presented a limited survival, benign tumours showed a very good prognosis. Conclusions Cardiac tumours require a multidisciplinary work-up to guarantee a prompt diagnosis and appropriate treatment. In our surgical experience, the prognosis of benign tumours was excellent, while malignant tumours had poor outcomes despite radical surgery.

Cardiac Tumors: Surgical Experience in Thirty-Nine Cases

1996 ◽  
Vol 4 (1) ◽  
pp. 14-17
Author(s):  
Rajendar Krishan Suri ◽  
Raghuvir Singh Kanwar ◽  
Harjinder Singh ◽  
Rajinder Singh Dhaliwal ◽  
Sandeep Singh Rana ◽  
...  
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Malignant Tumors ◽  
Fibrous Histiocytoma ◽  
Postoperative Radiotherapy ◽  
Right Atrial ◽  
Benign Tumors ◽  
Cardiac Tumors ◽  
Malignant Group ◽  
The Right

Over a period of 18 years, 39 cases of cardiac tumors were operated upon in the Department of Cardiothoracic Surgery at the Postgraduate Institute of Medical Education and Research, Chandigarh. These included 34 (87%) patients with benign tumors and 5 (13%) patients with primary malignant tumors. All the benign tumors were myxomas, of which 31 (91.2%) were in the left atrium and 3 (8.8%) in right atrium. Primary malignant tumors comprised 2 rhabdomyosarcomas, 1 angiosarcoma, 1 lymphoma and 1 case of pleomorphic malignant fibrous histiocytoma. The diagnosis was established by echocardiography, angiocardiography and computed tomography. In one case the diagnosis was made at autopsy. All myxomas, except tricuspid valve myxoma, were removed completely through right atrial or biatrial approach with the use of cardiopulmonary bypass. Four cases of primary malignant tumors were non-resectable. Near total resection of a malignant fibrous histiocytoma arising from the right middle pulmonary vein and left atrial junction was achieved. There were 2 operative deaths (5.1 %). The follow-up ranged from 3 months to 10 years with a mean of 5.7 years. There was 1 recurrence (2.9%) in the benign group. In the malignant group, 3 cases (60%) died within 5 to 8 months of surgery due to further local and metastatic spread of the tumor. The case of malignant fibrous histiocytoma was treated with postoperative radiotherapy to the right mediastinum and is doing well at follow-up 3 months after surgery.

scholarly journals Histopathological study of soft tissue tumours in a tertiary health centre in southern part of Assam

2021 ◽  
Vol 9 (11) ◽  
pp. 3391
Author(s):  
Khadija S. Tapadar ◽  
Manoj K. Deka ◽  
R. N. Chaubey ◽  
Shah A. Sheikh ◽  
Gargi R. Choudhury ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Malignant Tumors ◽  
Soft Tissue Tumors ◽  
The Body ◽  
World Health ◽  
Vascular Tumors ◽  
Benign Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Pleomorphic Sarcoma ◽  
Younger Age

Background: Soft tissue tumors are defined as mesenchymal proliferations which occur in the extraskeletal non-epithelial tissues of the body, excluding the viscera, coverings of brain and   lymphoreticular system. The objective of this study was to study the histopathological features of soft tissue tumors and to study the occurrence of soft tissue tumors in relation to age, sex and anatomical site.Methods: This study comprised of 89 cases studied over a period of two years. All soft tissue tumors, their gross features, microscopic findings were analysed in detail. Soft tissue tumors were divided into benign and malignant categories and further sub typing were done according to World Health Organization (WHO) classification. The distribution of soft tissue tumors according to the age, sex and site of occurrence was studied.Results: Out of 89 cases of soft tissue tumors, 76 cases were benign, 4 cases belonged to intermediate category and 9 cases were malignant. Adipocytic tumors formed the largest group constituting 39 cases. Vascular tumors were the second commonest (26 cases) followed by peripheral nerve sheath tumors (11 cases). The benign tumors were seen in younger age as compared to malignant tumors. Malignant soft tissue tumors was seen to be more common in male than female and pleomorphic sarcoma and liposarcoma was commonest (3 cases each).Conclusions: Benign tumors were more common than malignant. The most common benign tumors were lipoma followed by hemangioma and schwannoma. The most common malignant tumor was pleomorphic sarcoma. The benign tumors were seen in younger age as compared to malignant tumors.

Malignant tumours, pericardial tumours, and therapy

ESC CardioMed ◽  
2018 ◽  
pp. 1617-1624
Author(s):  
Cristina Basso ◽  
Stefania Rizzo ◽  
Marialuisa Valente ◽  
Martina Perazzolo Marra ◽  
Gaetano Thiene
Keyword(s):  
Malignant Neoplasms ◽  
Malignant Tumours ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Cardiac Tumours ◽  
Pleomorphic Sarcoma

Primary malignant neoplasms account for 10% of all primary cardiac tumours and are represented by sarcomas (mainly angiosarcoma, undifferentiated pleomorphic sarcoma, leiomyosarcoma) and primary lymphomas. They usually infiltrate the cardiac walls, but may be also solely intracavitary, mimicking myxoma.

U tim thai và sơ sinh: chẩn đoán trước sinh, theo dõi ba trường hợp và phẫu thuật thành công một trường hợp sau sinh tại Bệnh Viện Trung Ương Huế

2020 ◽  
Author(s):  
Du Le Ba Minh
Keyword(s):  
Heart Failure ◽  
Cardiac Tumor ◽  
Fetal Echocardiography ◽  
Ventricular Outflow Tract ◽  
Left Ventricular ◽  
Cardiac Tumors ◽  
Case Methods ◽  
Left Ventricular Outflow ◽  
Postnatal Surgery

Objective: Prenatal diagnosis, postnatal followed up of three cases of cardiac tumor and successful postnatal surgery of one case. Methods: Treatment and postnatal followed up of three cases of cardiac tumor. Those cases were diagnosed by fetal echocardiography. One of them underwent a successful postnatal surgery. Results: Three fetuses were diagnosed with fetal cardiac tumor (capable of Rhabdomyoma) at 28, 27, 38 gestational weeks. There were many tumors in one or two ventricles. These cases were referred to Hue Central Hospital for timing and location of delivery in 2019. One of them had obstruction of left ventricular outflow tract with successful surgical resection at 46 hours after birth. One of them had heart failure after birth. Evolution of three cases was favorable, heart failure regressed, cardiac tumors regressed at 7 - 9 months follow up. Conclusions: Fetal cardiac tumor can be diagnosed prenatally. Those three cases were capable of rhabdomyoma due to the presence of muliple tumors and their regression after birth. Neonatal surgical option should be reserved for the risk of cardiac flow obstruction.

scholarly journals Ventricular Tachycardia Associated with Radiation-Induced Cardiac Sarcoma

2014 ◽  
Vol 41 (6) ◽  
pp. 620-625 ◽  
Author(s):  
Elijah H. Beaty ◽  
Wassim Ballany ◽  
Richard G. Trohman ◽  
Christopher Madias
Keyword(s):  
Ventricular Tachycardia ◽  
Right Ventricular ◽  
Ventricular Arrhythmias ◽  
Malignant Tumors ◽  
Benign Tumors ◽  
Cardiac Tumors ◽  
Right Ventricular Free Wall ◽  
Undifferentiated Sarcoma ◽  
Electrocardiographic Changes ◽  
Radiation Induced

Cardiac tumors can lead to distinct electrocardiographic changes and ventricular arrhythmias. Benign and malignant cardiac tumors have been associated with ventricular tachycardia. When possible, benign tumors should be resected when ventricular arrhythmias are intractable. Chemotherapy can shrink malignant tumors and eliminate arrhythmias. We report the case of a 52-year-old woman with breast sarcoma whom we diagnosed with myocardial metastasis after she presented with palpitations. The initial electrocardiogram revealed sinus rhythm with new right bundle branch block and ST-segment elevation in the anterior precordial leads. During telemetry, hemodynamically stable, sustained ventricular tachycardia with right ventricular localization was detected. Images showed a myocardial mass in the right ventricular free wall. Amiodarone suppressed the arrhythmia. To our knowledge, this is the first report of ventricular tachycardia associated with radiation-induced undifferentiated sarcoma. We discuss the distinct electrocardiographic changes and ventricular arrhythmias that can be associated with cardiac tumors, and we review the relevant medical literature.

scholarly journals Neurogenic Tumors of the Mediastinum: A Report of 60 Cases

2000 ◽  
Vol 7 (3) ◽  
pp. 261-265 ◽  
Author(s):  
Salih Topçu ◽  
Aysin Alper ◽  
Erkmen Gülhan ◽  
Osman Koçyigit ◽  
Irfan Tastepe ◽  
...  
Keyword(s):  
Complete Resection ◽  
Infants And Children ◽  
Malignant Tumours ◽  
Autonomic Ganglion ◽  
Term Survival ◽  
Nerve Sheath ◽  
Chest Disease ◽  
Benign Tumours

OBJECTIVES:To analyze retrospectively 60 patients (13 infants and children, 47 adults - 21 men and 39 women) with mediastinal neurogenic tumours admitted to Atatürk Centre for Chest Disease and Chest Surgery, Ankara, Turkey between 1988 and 1999. This comprised 21.2% of 283 patients who had surgical operations for all mediastinal masses during the same period.PATIENTS AND METHODS:The patients ranged from four to 67 years of age. Thirteen patients were younger than 15 years and 47 were 15 years of age or older. Medical records were reviewed for demographic data, clinical presentation, diagnostic investigations, operative procedures, and tumour location and invasion. Postoperative morbidity and mortality were noted as well as long term follow-up. The clinical investigations included chest x-ray and computed tomography of the thorax in all patients, and spinal magnetic resonance imaging and bronchoscopical examination in some. Clinical variables were compared.RESULTS:The tumours had the following characteristics: 42 (70%) were nerve sheath tumours; 15 (25%) were autonomic ganglion tumours; two (3.6%) were paragangliomas; and one (1.4%) was a malignant peripheral neuroectodermal tumour (Askin's tumour). Nerve cell tumours comprised the majority of tumours in infants and children (nine of 13, 69%), whereas the nerve sheath tumours were most frequent in adults (39 of 47, 83%). There were 48 benign and 12 (20%) malignant tumours when all age groups were considered; the malignancy rate was 61.5% (eight of 13) in children and  8.5% (four of 47, P<0.05) in adults. All patients were operated via a posterolateral thoracotomy. Surgical resection of the tumour was complete in 56 of 60 patients (93.3%). Resection of malignant tumours was grossly incomplete in four cases (four of 12, 33.3%). All benign tumours were totally excised. There were two major complications (respiratory failure and pulmonary emboli) and 14 minor complications in the perioperative period. The mean follow-up period was five years and seven months. Tumours recurred in 5.3% (three of 56) of patients who had a complete resection initially. There were no late deaths related to benign tumours.CONCLUSIONS:Complete resection of tumours can be performed safely by a thoracotomy approach and is important for achieving satisfactory long term survival in most mediastinal neurogenic tumours.

scholarly journals Clinical Features and Treatment of Fibrous Histiocytomas of the Tongue: A Systematic Review

2017 ◽  
Vol 22 (01) ◽  
pp. 094-102 ◽  
Author(s):  
Austin Nguyen ◽  
Adam Vaudreuil ◽  
Paul Haun ◽  
Gabriel Caponetti ◽  
Christopher Huerter
Keyword(s):  
Surgical Treatment ◽  
Clinical Presentation ◽  
Malignant Tumors ◽  
Case Reports ◽  
Data Synthesis ◽  
Excellent Outcome ◽  
Fibrous Histiocytomas ◽  
Pleomorphic Sarcoma ◽  
Level Data

Introduction Benign fibrous histiocytomas are common lesions of the skin that rarely affect the tongue. Such cases are available in the literature exclusively as case reports. Similarly, malignant fibrous histiocytoma, now classified as undifferentiated pleomorphic sarcoma, is exceedingly rare in the tongue and not fully understood. Objectives This study systematically reviews the available literature discussing the clinical and pathological features of malignant and benign fibrous histiocytomas. Data Synthesis A total of 20 cases were included in this review. Patient-level data were extracted from cases to include clinical presentation, workup, treatment, and outcome. Conclusion Benign fibrous histiocytomas are consistent in clinical and histopathologic presentation. Surgical treatment provides excellent outcome, with no recurrence in all excised cases. Malignant tumors have a more aggressive clinical and pathological presentation. Surgical treatment with possible adjuvant radiotherapy resulted in recurrence in 40% of cases (follow-up of 24 months), and death due to disease in 47% of patients (follow-up of 19 months).

Surgical Treatment of Primary Cardiac Tumors—Experience with 45 Patients

1995 ◽  
Vol 3 (2) ◽  
pp. 49-52
Author(s):  
Lin Jue Yi ◽  
Chu Shu Hsun ◽  
Lee Yuan Teh ◽  
Wang Shoei Shen ◽  
Lin Fang Yue ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Left Atrium ◽  
Malignant Tumors ◽  
Thyroid Tissue ◽  
University Hospital ◽  
Benign Tumors ◽  
Cardiac Tumors ◽  
Incomplete Resection ◽  
Long Term Result ◽  
Primary Cardiac Tumors

Primary cardiac tumors are very rare and the majority of them are histologically benign and surgically curable. During a 30-year period from 1963 to January 1993, 45 cases of primary cardiac tumors were surgically excised at the National Taiwan University Hospital, representing 0.52% of 8,695 open heart surgical cases during the same period. In this series, 42 cases (94%) were benign tumors; 39 (88%) were myxoma (30 female, 9 male), and 32 (82%) originated in the left atrium. None were discovered in the left ventricle. In all but the first 6 cases, tumors in patients with myxoma in the left atrium were successfully excised by the transseptal approach. There were 3 patients with rare benign tumors: intracardiac goiter, rhabdomyoma, and hemangioma respectively. The intracardiac goiter was completely excised with no ectopic thyroid tissue after operation and the other 2 received palliative resection. The latter 2 patients suffered no recurrence. Rhabdomyosarcoma, leiomyosarcoma and malignant lymphoma were noted in one patient each, all of whom died of low cardiac output in the early postoperative course. In our experience, the majority of primary cardiac tumors were benign and located in the left atrium. The long-term result of surgical treatment of benign cardiac tumors is excellent, even incases of incomplete resection, while the results from surgical treatment of malignant tumors is poor.

Medical and surgical management of primary cardiac tumours in infants and children

2013 ◽  
Vol 24 (2) ◽  
pp. 268-274 ◽  
Author(s):  
Massimo A. Padalino ◽  
Elena Reffo ◽  
Alessia Cerutti ◽  
Valentina Favero ◽  
Roberta Biffanti ◽  
...  
Keyword(s):  
Case Reports ◽  
Infants And Children ◽  
Malignant Tumours ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Cardiac Tumours ◽  
Dimensional Echocardiography ◽  
In Infants And Children

AbstractPrimary cardiac tumours in infants and children are extremely rare, with an estimated incidence of 0.2% according to echocardiographic studies. Owing to their rarity, there is very little literature available, and most knowledge is based on collections of case reports. Therefore, we reviewed retrospectively our 27 years of clinical experience on the overall management of cardiac tumours among children in order to improve not only our knowledge but also to provide others with information about the incidence, clinical presentation, management, and long-term outcome of this rare disease. Between April, 1982 and April, 2009, 52 children were diagnosed with cardiac tumours at our Institution. Medical records and follow-up echocardiographic evaluations were studied. The diagnosis was prenatal in 35% of the patients. The most frequent tumour types were rhabdomyomas (61.5%), fibromas (15.4%), and myxomas (5.8%). There were no cases of primary malignant tumours. All diagnoses were achieved using two-dimensional echocardiography, and for 12 patients a pathological analysis was carried out. A total of 41 patients (79%) were managed medically, whereas 11 (21%) patients underwent surgical treatment. At a mean follow-up of 7.2 ± 5.4 years, two patients died of complications related to cardiac transplantation; all the remaining patients are in excellent clinical condition. In conclusion, cardiac tumours in paediatric practice are usually clinically and histologically benign. Only a few cases need surgery. Up to one-third of the cardiac masses are detectable prenatally. Rhabdomyoma is the most common histotype, followed by fibroma and myxoma. The long-term prognosis is generally good.

scholarly journals Clinical classification of cardiovascular tumors and tumor-like lesions, and its incidences

2013 ◽  
Vol 61 (8) ◽  
pp. 435-447 ◽  
Author(s):  
Jun Amano ◽  
Jun Nakayama ◽  
Yasuo Yoshimura ◽  
Uichi Ikeda
Keyword(s):  
Malignant Tumors ◽  
Cardiac Myxoma ◽  
World Health ◽  
Benign Tumors ◽  
Cardiac Tumors ◽  
New Classification ◽  
Metastatic Tumors ◽  
Great Vessels ◽  
Tumor Like Lesions

Abstract Tumors of the heart and the great vessels are very rare disease, and there are many disorders such as tumors originated from the heart and great vessels, metastatic tumors, and tumor-like lesions which do not fit into the usual concept of tumor or neoplasm; thus, it is very difficult to classify these tumors. We proposed a new classification of cardiovascular tumors for clinical use based on the accumulated biological analyses and clinical data of the reported literatures and our own study as benign tumors, malignant tumors, ectopic hyperplasia/ectopic tumors/others, and tumors of great vessels, with reference to the series of Atlas of tumor pathology of the Armed Forces Institute of Pathology and the recent World Health Organization classification of cardiac tumors issued in 2004. More than 50 disorders have been reported as tumors originated from the cardiovascular system, and various metastatic tumors from nearby organs, distant lesions, and intravascular extension tumors to the heart were reported. Based on the new classification, we reviewed epidemiology and incidence of cardiovascular tumors. Metastatic tumors are more frequent than tumors originated from the heart and great vessels, and cardiac myxoma is the most frequent tumors in all cardiac tumors.

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