Stress testing for myocardial perfusion scintigraphy

Author(s):  
Nikant Sabharwal ◽  
Chee Yee Loong ◽  
Andrew Kelion

Coronary physiology and stress testing 76Practical requirements for stress testing 78Patient preparation for stress 80Exercise stress: general considerations 82Exercise stress: practical aspects 84Exercise stress: performing the test 86Vasodilator drugs: pharmacology 88Vasodilator drugs: practical considerations 92Vasodilator drugs: performing the stress test ...

Author(s):  
Nikant Sabharwal ◽  
Parthiban Arumugam ◽  
Andrew Kelion

This chapter focuses on stress testing for myocardial perfusion scintigraphy. Beginning with detail on coronary physiology and exercise testing, it explains the coronary arterial system and the effect of stress methods on flow. By providing practical details on stress testing and exercise stress including equipment, personnel, and patient preparation, this chapter provides a good basis for clinical practice. Information on vasodilator drugs is also provided, with detail on pharmacology, practical considerations when performing the stress test, and adverse effects. Similar detail is provided on dobutamine. A further section details the advantages and disadvantages of methods of stress, including cost considerations, side effects, and variable suitability for a range of patients. A handy and practical algorithm is also provided to aid decision-making for appropriate methods of stress.


2007 ◽  
Vol 8 (3) ◽  
pp. 2
Author(s):  
Jose Marconi Almeida de Sousa ◽  
Paola Emanuela Poggio Smanio ◽  
Antonio Sergio Tebexreni ◽  
Paulo Cesar Gobert Damasceno Campos ◽  
Filadelfo Rodrigues Filho ◽  
...  

1998 ◽  
Vol 37 (08) ◽  
pp. 268-271
Author(s):  
B. Caner ◽  
E. Atalar ◽  
A. Karanfil ◽  
L. Tokgözoğlu ◽  
E. L. Ergün

Summary Aim: Dobutamine as a predominant beta-1 agonist increases heart rate and myocardial contractility and at sufficient high doses, it also increases systolic blood pressure. This study was undertaken to describe instances of paradoxical hypotension during dobutamine infusion for TI-201 myocardial perfusion SPECT study and the relationship between scintigraphic findings and hypotension occurred during dobutamine infusion. Methods: In 201 consecutive patients unable to perform adequate exercise, dobutamine TI-201 myocardial SPECT was performed. Dobutamine was infused starting from 10 μg/kg/min increasing to 40 μg/kg/min. Paradoxical hypotension was defined as a decrease in systolic blood pressure ≥ 20 mmHg compared with baseline study. Results: Paradoxical hypotension was observed in 40 patients (Group A) out of 201 (19.9%) while no significant change in systolic blood pressure was detected in the remaining 161 patients (Group B). Mean maximum fall in systolic blood pressure was 39 ± 18 mmHg (range: 20-90). In 33 of 40 patients (83%) with paradoxical hypotension, scintigraphy was normal compared to 131 (81%) of the remaining 161 patients. In patients of Group A, angiography, echocardiography and tilt table tests were performed in 13, 11 and 6 patients respectively. Nine of 13 angiographic evaluations (69%), 10 of 11 echocardiographic evaluations (91%), all of the tilt table tests were normal. Additionally, all of the patients of Group A were clinically followed up at least 6 months after the myocardial perfusion scintigraphy. None of the patients had a cardiac event except one patient during the follow-up period. Conclusion: Paradoxical hypotension during dobutamine infusion for myocardial scintigraphy is not an uncommon finding and up to 19.9% patients may develop such hypotension. To maximize test safety, precautions should be taken during dobutamine myocardial stress test, since remarkable decrease in systolic blood pressure may occur. Unlike hypotension occurring with exercise test, hypotension response to dobutamine is not always a marker for coronary artery disease.


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