Biologic and Regenerative Therapies

2018 ◽  
Author(s):  
Ian Dworkin ◽  
Daniel A. Fung ◽  
Timothy T. Davis
Keyword(s):  
Degenerative Disc Disease ◽  
Current Treatment ◽  
Treatment Modalities ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Novel Approach ◽  
Current Therapies ◽  
Regenerative Therapies

Low back pain is one of the most debilitating conditions worldwide, and a major cause is degenerative disc disease. Current therapies range from conservative treatments, such as medications, physical therapy, and other modalities, to more invasive treatments such as injections and surgery; however, these therapies neither stop the progression of degeneration nor restore function to the degenerating disc; they focus on symptom management, not on etiology. A novel approach to treating degenerative disc disease involves using regenerative therapies such as stem cells, growth factors, and gene therapy. The goal of these therapies is not just to decrease symptoms, but to reverse disc degeneration, while simultaneously enhancing current treatment modalities. Though clinical translation of regenerative therapies is in its infancy, in vitro and in vivo investigations have revealed these therapies’ potential in treating degenerative disc disease as well as a multitude of other musculoskeletal conditions.

scholarly journals Titanium-interlayer mediated hydroxyapatite coating on polyetheretherketone: a prospective study in patients with single-level cervical degenerative disc disease

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ce Zhu ◽  
Miaomiao He ◽  
Lili Mao ◽  
Tao Li ◽  
Li Zhang ◽  
...  
Keyword(s):  
Degenerative Disc Disease ◽  
Fusion Rate ◽  
Peek Cage ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Single Level ◽  
Cervical Degenerative Disc Disease ◽  
Post Operation

Abstract Background Currently, there are limited reports regarding investigation of the biological properties of polyetheretherketone (PEEK) coated with titanium (Ti) and hydroxyapatite (HA) in human. The objective of this study is to evaluate the in vivo response of the PEEK cages coated with Ti and HA versus uncoated PEEK cages after anterior cervical discectomy and fusion (ACDF) in patients with single-level cervical degenerative disc disease (CDDD). Methods Twenty-four patients with PEEK cages coated with Ti and HA (PEEK/Ti/HA group) were matched one-to-one with patients with uncoated PEEK cages (PEEK group) based on age, gender, and operative segment. All patients had been followed up for more than 2 years. Radiological assessments included intervertebral height (IH), C2-7 angle (C2-7a), segmental alignment (SA), and fusion rate. Clinical parameters included Visual Analogue Scale (VAS) and Japanese Orthopedic Association (JOA) scores. Results There was no statistical difference in SA, IH, and C2-7a between the two groups before and after surgery and all these parameters were restored postoperatively. The fusion rate of PEEK/Ti/HA group was significantly higher than PEEK group at 3-month post-operation (87.5% vs. 62.5%). At the last follow-up, the fusion rate of the both groups achieved 100%. The VAS and JOA scores were comparable between two groups and improved postoperatively. Conclusions In patients with single-level ACDF, PEEK cage coated with Ti and HA provided a higher fusion rate than uncoated PEEK cage at 3-month post-operation, while both two cages could achieve solid osseous fusion at the last follow up. Compared with the uncoated PEEK cage, PEEK/Ti/HA cage yielded similar favorable segmental and overall cervical lordosis, IH, and clinical outcomes after the surgery.

The Diagnostic Performance of Vertebral Displacement Measurements Derived From Ultrasonic Indentation in an In Vivo Model of Degenerative Disc Disease

Spine ◽  
2001 ◽  
Vol 26 (12) ◽  
pp. 1348-1355 ◽  
Author(s):  
Gregory N. Kawchuk ◽  
Allison M. Kaigle ◽  
Sten H. Holm ◽  
O. Rod Fauvel ◽  
Lars Ekström ◽  
...  
Keyword(s):  
Degenerative Disc Disease ◽  
Diagnostic Performance ◽  
In Vivo Model ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Displacement Measurements

scholarly journals An in vivo model of degenerative disc disease

2003 ◽  
Vol 21 (1) ◽  
pp. 183-188 ◽  
Author(s):  
Jason P. Norcross ◽  
Gayle E. Lester ◽  
Paul Weinhold ◽  
Laurence E. Dahners
Keyword(s):  
Degenerative Disc Disease ◽  
In Vivo Model ◽  
Disc Disease ◽  
Degenerative Disc

scholarly journals Inflammation in intervertebral disc degeneration and regeneration

2015 ◽  
Vol 12 (104) ◽  
pp. 20141191 ◽  
Author(s):  
Maria Molinos ◽  
Catarina R. Almeida ◽  
Joana Caldeira ◽  
Carla Cunha ◽  
Raquel M. Gonçalves ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Intervertebral Disc Degeneration ◽  
Cellular Interactions ◽  
Disc Disease ◽  
Discogenic Pain ◽  
Extracellular Matrix Remodelling ◽  
Ivd Degeneration ◽  
Regenerative Therapies

Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a problem with a heavy economic burden, which has been increasing in prevalence as populations age. Deeper knowledge of the complex spatial and temporal orchestration of cellular interactions and extracellular matrix remodelling is critical to improve current IVD therapies, which have so far proved unsatisfactory. Inflammation has been correlated with degenerative disc disease but its role in discogenic pain and hernia regression remains controversial. The inflammatory response may be involved in the onset of disease, but it is also crucial in maintaining tissue homeostasis. Furthermore, if properly balanced it may contribute to tissue repair/regeneration as has already been demonstrated in other tissues. In this review, we focus on how inflammation has been associated with IVD degeneration by describing observational and in vitro studies as well as in vivo animal models. Finally, we provide an overview of IVD regenerative therapies that target key inflammatory players.

scholarly journals Titanium-interlayer Mediated Hydroxyapatite Coating on Polyetheretherketone: A Prospective Study in Patients with Single-level Cervical Degenerative Disc Disease

2020 ◽  
Author(s):  
Ce zhu ◽  
Miaomiao He ◽  
Lili Mao ◽  
Tao LI ◽  
Li Zhang ◽  
...  
Keyword(s):  
Degenerative Disc Disease ◽  
Fusion Rate ◽  
Peek Cage ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Single Level ◽  
Cervical Degenerative Disc Disease ◽  
Post Operation

Currently, there are limited reports regarding investigation of the biological properties of polyetheretherketone (PEEK) coated with titanium (Ti) and hydroxyapatite (HA) in human. The objective of this study is to evaluate the in vivo response of the PEEK cages coated with Ti and HA versus uncoated PEEK cages after anterior cervical discectomy and fusion (ACDF) in patients with single-level cervical degenerative disc disease (CDDD). Twenty-four patients with PEEK cages coated with Ti and HA (PEEK/Ti/HA group) were matched one-to-one with patients with uncoated PEEK cages (PEEK group) based on age, gender, and operative segment. All patients had been followed up for more than 2 years. Radiological assessments included intervertebral height (IH), C2-7 angle(C2-7a), segmental alignment (SA), and fusion rate. Clinical parameters included Visual Analogue Scale (VAS) and Japanese Orthopedic Association (JOA) scores. There was no statistical difference in SA, IH, and C2-7a between the two groups before and after surgery and all these parameters were restored postoperatively. The fusion rate of PEEK/Ti/HA group was significantly higher than PEEK group at 3-month post-operation (87.5% vs. 62.5%). At the last follow-up, the fusion rate of the both groups achieved 100%. The VAS and JOA scores were comparable between two groups and improved postoperatively. In conclusion, in patients with single-level ACDF, PEEK cage coated with Ti and HA provided a higher fusion rate than uncoated PEEK cage at 3-month post-operation, while both of the two cages could achieve solid osseous fusion at the last follow up. Compared with the uncoated PEEK cage, PEEK/Ti/HA cage yielded similar favorable segmental and overall cervical lordosis, IH, and clinical outcomes after the surgery.

scholarly journals In Vivo Characteristics of Nondegenerated Adjacent Segment Intervertebral Foramina in Patients With Degenerative Disc Disease During Flexion-Extension

Spine ◽  
2017 ◽  
Vol 42 (6) ◽  
pp. 359-365
Author(s):  
Thomas D. Cha ◽  
Gregory Moore ◽  
Ming Han Lincoln Liow ◽  
Weiye Zhong ◽  
Minfei Wu ◽  
...  
Keyword(s):  
Degenerative Disc Disease ◽  
Adjacent Segment ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Flexion Extension ◽  
Intervertebral Foramina

scholarly journals How Does Lumbar Degenerative Disc Disease Affect the Disc Deformation at the Cephalic Levels In Vivo?

Spine ◽  
2011 ◽  
Vol 36 (9) ◽  
pp. E574-E581 ◽  
Author(s):  
Shaobai Wang ◽  
Qun Xia ◽  
Peter Passias ◽  
Weishi Li ◽  
Kirkham Wood ◽  
...  
Keyword(s):  
Degenerative Disc Disease ◽  
Disc Disease ◽  
Lumbar Degenerative Disc Disease ◽  
Degenerative Disc

scholarly journals The “tract” of history in the treatment of lumbar degenerative disc disease

2004 ◽  
Vol 16 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Khalil J. Chedid ◽  
Mokbel K. Chedid
Keyword(s):  
Lumbar Spine ◽  
Degenerative Disc Disease ◽  
Current Treatment ◽  
Disc Disease ◽  
Lumbar Degenerative Disc Disease ◽  
Degenerative Disc ◽  
Therapeutic Implications ◽  
Long Time ◽  
History Of ◽  
Treatment Procedures

In this paper past, present, and future treatments of degenerative disc disease (DDD) of the lumbar spine are outlined in a straight forward manner. This is done to review previous knowledge of the disease, define current treatment procedures, and discuss future perspectives. An analysis of a subject of this magnitude dictates that one describes as accurate a history as possible: an anatomical/historical “tract” with emphasis on all possible deviations. Although spinal disorders have been recognized for a long time, the view of DDD as a particular disease entity is a more recent development. In this paper, the authors attempt to outline the history of DDD of the lumbar spine in an unbiased and scientific fashion. Physiological, diagnostic, and therapeutic implications will all be addressed in this study.

scholarly journals Advances in Research of Adult Gliomas

2021 ◽  
Vol 22 (2) ◽  
pp. 924
Author(s):  
Alina Finch ◽  
Georgios Solomou ◽  
Victoria Wykes ◽  
Ute Pohl ◽  
Chiara Bardella ◽  
...  
Keyword(s):  
Brain Tumours ◽  
Treatment Options ◽  
Current Treatment ◽  
In Vivo Models ◽  
Malignant Brain Tumours ◽  
Current Therapies ◽  
Diffuse Gliomas ◽  
In Silico Models

Diffuse gliomas are the most frequent brain tumours, representing 75% of all primary malignant brain tumours in adults. Because of their locally aggressive behaviour and the fact that they cannot be cured by current therapies, they represent one of the most devastating cancers. The present review summarises recent advances in our understanding of glioma development and progression by use of various in vitro and in vivo models, as well as more complex techniques including cultures of 3D organoids and organotypic slices. We discuss the progress that has been made in understanding glioma heterogeneity, alteration in gene expression and DNA methylation, as well as advances in various in silico models. Lastly current treatment options and future clinical trials, which aim to improve early diagnosis and disease monitoring, are also discussed.

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