Somatic treatments

2012 ◽  
Author(s):  
Raymond W. Lam
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Electroconvulsive Therapy ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Light Therapy ◽  
Limited Data ◽  
Non Invasive ◽  
Resistant Depression ◽  
Term Management

• Wake therapy, exercise and light therapy are non-invasive and clinically useful treatments.• Electroconvulsive therapy remains an effective, safe and well-tolerated treatment for patients with severe, psychotic or medication-resistant depression.• Repetitive transcranial magnetic stimulation is an emerging treatment with evidence for acute efficacy, but with limited data about long-term management....

Somatic treatments

Depression ◽  
2018 ◽  
pp. 85-94
Author(s):  
Raymond W. Lam
Keyword(s):  
Vagus Nerve Stimulation ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Light Therapy ◽  
Good Evidence ◽  
Refractory Depression ◽  
Non Invasive ◽  
Resistant Depression ◽  
Term Management

Somatic treatments for depression include non-invasive modalities such as wake therapy (sleep deprivation), exercise, and light therapy. The modern techniques now used for electroconvulsive therapy make it an effective, safe, and well-tolerated (but still underutilized) treatment for patients with severe, psychotic, or medication-resistant depression. Repetitive transcranial magnetic stimulation now has good evidence for acute efficacy, but its use is still limited by lack of data on maintenance and long-term management. Surgical and neuromodulation treatments, such as vagus nerve stimulation, deep brain stimulation, and limbic neurosurgery, may be clinically useful for some patients with difficult-to-treat and refractory depression.

scholarly journals Efficacy of repetitive transcranial magnetic stimulation in treatment-resistant depression: the evidence thus far

2019 ◽  
Vol 32 (4) ◽  
pp. e100074 ◽  
Author(s):  
Aditya Somani ◽  
Sujita Kumar Kar
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Electroconvulsive Therapy ◽  
Magnetic Stimulation ◽  
Antidepressant Treatment ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Common Mental Disorder ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Number Of Patients ◽  
Resistant Depression

Depression is a common mental disorder, which attributes to significant morbidity, disability and burden of care. A significant number of patients with depression still remain symptomatic after adequate trials of antidepressant treatment as well as psychotherapy, which is often referred to as treatment-resistant depression. Neuromodulation techniques—like electroconvulsive therapy, vagus nerve stimulation, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation, may be useful augmenting techniques in depression, mostly recommended for treatment-resistant cases. Robust evidence exists regarding the efficacy of electroconvulsive therapy in the management of treatment-resistant depression; however, other techniques are understudied. TMS has been increasingly studied in various psychiatric disorders including depression. It has been approved by the US Food and Drug Administration for use in major depressive disorder. Over the past two decades, TMS has been studied in diverse groups of the population with depression using several research designs. This article gives an overview of the efficacy of repetitive TMS in treatment-resistant depression with the recent evidence.

The priming effect of repetitive transcranial magnetic stimulation on clinical response to electroconvulsive therapy in treatment-resistant depression: a randomized, double-blind, sham-controlled study

2021 ◽  
pp. 1-12
Author(s):  
Maud Rothärmel ◽  
Pierre Quesada ◽  
Thomas Husson ◽  
Ghina Harika-Germaneau ◽  
Clément Nathou ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Clinical Response ◽  
Electroconvulsive Therapy ◽  
Magnetic Stimulation ◽  
Priming Effect ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Double Blind ◽  
Resistant Depression

Abstract Background Electroconvulsive therapy (ECT) is one of the most effective treatments for treatment-resistant depression (TRD). However, due to response delay and cognitive impairment, ECT remains an imperfect treatment. Compared to ECT, repetitive transcranial magnetic stimulation (rTMS) is less effective at treating severe depression, but has the advantage of being quick, easy to use, and producing almost no side effects. In this study, our objective was to assess the priming effect of rTMS sessions before ECT on clinical response in patients with TRD. Methods In this multicenter, randomized, double-blind, sham-controlled trial, 56 patients with TRD were assigned to active or sham rTMS before ECT treatment. Five sessions of active/sham neuronavigated rTMS were administered over the left dorsolateral prefrontal cortex (20 Hz, 90% resting motor threshold, 20 2 s trains with 60-s intervals, 800 pulses/session) before ECT (which was active for all patients) started. Any relative improvements were then compared between both groups after five ECT sessions, in order to assess the early response to treatment. Results After ECT, the active rTMS group exhibited a significantly greater relative improvement than the sham group [43.4% (28.6%) v. 25.4% (17.2%)]. The responder rate in the active group was at least three times higher. Cognitive complaints, which were assessed using the Cognitive Failures Questionnaire, were higher in the sham rTMS group compared to the active rTMS group, but this difference was not corroborated by cognitive tests. Conclusions rTMS could be used to enhance the efficacy of ECT in patients with TRD. ClinicalTrials.gov: NCT02830399.

Repetitive transcranial magnetic stimulation as a maintenance therapy strategy after electroconvulsive therapy: a conceptual review

2016 ◽  
Vol Ano 6 ◽  
pp. 6-13
Author(s):  
Mercedes Jurema Oliveira Alves
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Maintenance Therapy ◽  
Electroconvulsive Therapy ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Therapy Strategy

O presente texto faz uma revisão das bases teóricas e dos estudos empíricos disponíveis sobre o uso da estimulação magnética transcraniana de repetição como estratégia terapêutica de manutenção após eletroconvulsoterapia. Há quadros psiquiátricos pouco responsivos a quaisquer tipos de tratamentos, inclusive à eletroconvulsoterapia. O texto mostra que a combinação das técnicas é promissora, porém mais estudos são necessários para se definir as indicações precisas e a eficácia em termos de sustentação da resposta terapêutica.

Sign in / Sign up

Export Citation Format

Share Document