Granulocyte Colony Stimulating Factor (G-CSF) for Mustard-Induced Bone Marrow Suppression

1993 ◽  
Vol 158 (7) ◽  
pp. 470-474 ◽  
Author(s):  
Barry R. Meisenberg ◽  
Anthony J. Melaragno ◽  
Rodney L. Monroy
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Suppression ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor ◽  
Factor G

Colchicine-induced bone marrow suppression: treatment with granulocyte colony-stimulating factor

2000 ◽  
Vol 18 (4) ◽  
pp. 435-440 ◽  
Author(s):  
Roger Harris ◽  
Gavin Marx ◽  
Mark Gillett ◽  
Adrian Kark ◽  
Shalini Arunanthy
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Suppression ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

scholarly journals Successful Treatment of Cisplatin Overdose with Plasma Exchange

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Yasuhiro Yamada ◽  
Yoshiaki Ikuta ◽  
Kisato Nosaka ◽  
Nobutomo Miyanari ◽  
Naoko Hayashi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adjuvant Therapy ◽  
Supportive Care ◽  
Plasma Exchange ◽  
Bone Marrow Suppression ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Subtotal Esophagectomy ◽  
Intravenous Hydration ◽  
Stimulating Factor

Accidental cisplatin overdose has been occurring with an increasing frequency due to expanding usage of the agent. However, the optimal strategy to treat such patients remains to be established. Here, we report a case of large cisplatin overdose, successfully managed by plasma exchange, intravenous hydration, granulocyte colony-stimulating factor (G-CSF) administration, and other supportive care. A 67-year-old man with esophageal carcinoma received a large cisplatin overdose of 240 , when he received adjuvant therapy following subtotal esophagectomy. On day 4, he experienced frank cisplatin toxicities and emergency plasma exchange was initiated. With 7 cycles of plasma exchange, the cisplatin concentration decreased from 2,350 to 110 ng/mL. Severe bone marrow suppression with high fever ensued on day 10, which was successfully treated with G-CSF and antibiotics. Despite moderate hearing sense reduction, he recovered without significant complications. Immediate plasma exchange with hydration and other care was efficacious in quickly lowering cisplatin concentrations.

Human Granulocyte Colony-Stimulating Factor (G-CSF) Stimulates the In Vitro and In Vivo Development But Not Commitment of Primitive Multipotential Progenitors From Transgenic Mice Expressing the Human G-CSF Receptor

Blood ◽  
1998 ◽  
Vol 92 (12) ◽  
pp. 4632-4640 ◽  
Author(s):  
Feng-Chun Yang ◽  
Sumiko Watanabe ◽  
Kohichiro Tsuji ◽  
Ming-jiang Xu ◽  
Azusa Kaneko ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Blast Cell ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Hematopoietic Progenitors ◽  
Clonal Cultures ◽  
Stimulating Factor ◽  
Factor G

Granulocyte colony-stimulating factor (G-CSF) stimulates the proliferation and restricted differentiation of hematopoietic progenitors into neutrophils. To clarify the effects of G-CSF on hematopoietic progenitors, we generated transgenic (Tg) mice that had ubiquitous expression of the human G-CSF receptor (hG-CSFR). In clonal cultures of bone marrow and spleen cells obtained from these mice, hG-CSF supported the growth of myelocytic as well as megakaryocytic, mast cell, mixed, and blast cell colonies. Single-cell cultures of lineage-negative (Lin−)c-Kit+Sca-1+ or Sca-1− cells obtained from the Tg mice confirmed the direct effects of hG-CSF on the proliferation and differentiation of various progenitors. hG-CSF also had stimulatory effects on the formation of blast cell colonies in cultures using 5-fluorouracil–resistant hematopoietic progenitors and clone-sorted Lin−c-Kit+Sca-1+ primitive hematopoietic cells. These colonies contained different progenitors in proportions similar to those obtained when mouse interleukin-3 was used in place of hG-CSF. Administration of hG-CSF to Tg mice led to significant increases in spleen colony-forming and mixed/blast cell colony-forming cells in bone marrow and spleen, but did not alter the proportion of myeloid progenitors in total clonogenic cells. These results show that, when functional G-CSFR is present on the cell surface, hG-CSF stimulates the development of primitive multipotential progenitors both in vitro and in vivo, but does not induce exclusive commitment to the myeloid lineage.

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