scholarly journals Variability of G2 checkpoint sensitivity to low doses of X-rays (2 cGy): correlation with G2 chromatid aberrations but not with an adaptive response

Mutagenesis ◽  
2000 ◽  
Vol 15 (6) ◽  
pp. 531-535 ◽  
Author(s):  
V. Pretazzoli
Keyword(s):  
Adaptive Response ◽  
Low Doses ◽  
X Rays ◽  
G2 Checkpoint ◽  
Chromatid Aberrations

Adaptive response to 2 low doses of X-rays in human blood lymphocytes

1990 ◽  
Vol 243 (1) ◽  
pp. 53-56 ◽  
Author(s):  
S. Fan ◽  
Vijayalaxmi ◽  
G. Mindek ◽  
W. Burkart
Keyword(s):  
Human Blood ◽  
Adaptive Response ◽  
Low Doses ◽  
X Rays ◽  
Blood Lymphocytes ◽  
Human Blood Lymphocytes

Characterization of the Adaptive Response to Ionizing Radiation Induced by Low Doses of X Rays to Human Lymphocytes

1987 ◽  
Vol 111 (3) ◽  
pp. 511 ◽  
Author(s):  
Jeffery D. Shadley ◽  
Veena Afzal ◽  
Sheldon Wolff
Keyword(s):  
Ionizing Radiation ◽  
Adaptive Response ◽  
Human Lymphocytes ◽  
Low Doses ◽  
X Rays ◽  
Radiation Induced

scholarly journals Cytogenetic Adaptive Response of Cultured Fish Cells to Low Doses of X-rays.

1992 ◽  
Vol 33 (4) ◽  
pp. 267-274 ◽  
Author(s):  
YASUYUKI KURIHARA ◽  
MATI RIENKJKARN ◽  
HISAMI ETOH
Keyword(s):  
Adaptive Response ◽  
Low Doses ◽  
X Rays ◽  
Cultured Fish ◽  
Fish Cells

scholarly journals Strong Shift to ATR-Dependent Regulation of the G2-Checkpoint after Exposure to High-LET Radiation

Life ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 560
Author(s):  
Veronika Mladenova ◽  
Emil Mladenov ◽  
Michael Scholz ◽  
Martin Stuschke ◽  
George Iliakis
Keyword(s):  
Chromosomal Abnormalities ◽  
Biological Effects ◽  
Cell Killing ◽  
Space Environment ◽  
Low Doses ◽  
X Rays ◽  
G2 Checkpoint ◽  
High Let Radiation ◽  
High Let ◽  
Α Particles

The utilization of high linear-energy-transfer (LET) ionizing radiation (IR) modalities is rapidly growing worldwide, causing excitement but also raising concerns, because our understanding of their biological effects is incomplete. Charged particles such as protons and heavy ions have increasing potential in cancer therapy, due to their advantageous physical properties over X-rays (photons), but are also present in the space environment, adding to the health risks of space missions. Therapy improvements and the protection of humans during space travel will benefit from a better understanding of the mechanisms underpinning the biological effects of high-LET IR. There is evidence that high-LET IR induces DNA double-strand breaks (DSBs) of increasing complexity, causing enhanced cell killing, owing, at least partly, to the frequent engagement of a low-fidelity DSB-repair pathway: alternative end-joining (alt-EJ), which is known to frequently induce severe structural chromosomal abnormalities (SCAs). Here, we evaluate the radiosensitivity of A549 lung adenocarcinoma cells to X-rays, α-particles and 56Fe ions, as well as of HCT116 colorectal cancer cells to X-rays and α-particles. We observe the expected increase in cell killing following high-LET irradiation that correlates with the increased formation of SCAs as detected by mFISH. Furthermore, we report that cells exposed to low doses of α-particles and 56Fe ions show an enhanced G2-checkpoint response which is mainly regulated by ATR, rather than the coordinated ATM/ATR-dependent regulation observed after exposure to low doses of X-rays. These observations advance our understanding of the mechanisms underpinning high-LET IR effects, and suggest the potential utility for ATR inhibitors in high-LET radiation therapy.

scholarly journals Indications of Repair of Radon-Induced Chromosome Damage in Human Lymphocytes: An Adaptive Response Induced by Low Doses of X-Rays

1993 ◽  
Vol 101 ◽  
pp. 73 ◽  
Author(s):  
Sheldon Wolff ◽  
Veena Afzal ◽  
Rick F. Jostes ◽  
John K. Wiencke
Keyword(s):  
Adaptive Response ◽  
Human Lymphocytes ◽  
Chromosome Damage ◽  
Low Doses ◽  
X Rays

ADAPTIVE RESPONSE TO LOW DOSES OF X-RAYS IN PREIMPLANTATION MOUSE EMBRYOS?

1991 ◽  
pp. 228
Author(s):  
A. WOJCIK ◽  
W.-U. MÜLLER ◽  
F. NIEDEREICHHOLZ ◽  
K. WUTTKE ◽  
C. STREFFER
Keyword(s):  
Adaptive Response ◽  
Mouse Embryos ◽  
Low Doses ◽  
X Rays ◽  
Preimplantation Mouse Embryos ◽  
Preimplantation Mouse
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