scholarly journals Genotoxicity induced by arsenic compounds in peripheral human lymphocytes analysed by cytokinesis-block micronucleus assay

Mutagenesis ◽  
2007 ◽  
Vol 22 (4) ◽  
pp. 255-261 ◽  
Author(s):  
R. Colognato ◽  
F. Coppede ◽  
J. Ponti ◽  
E. Sabbioni ◽  
L. Migliore
Keyword(s):  
Human Lymphocytes ◽  
Micronucleus Assay ◽  
Arsenic Compounds

scholarly journals Micronucleus assay in human lymphocytes after exposure to alloxydim sodium herbicide in vitro

2014 ◽  
Vol 67 (6) ◽  
pp. 1059-1066 ◽  
Author(s):  
Dilek Akyıl ◽  
Arzu Özkara ◽  
S. Feyza Erdoğmuş ◽  
Yasin Eren ◽  
Muhsin Konuk ◽  
...  
Keyword(s):  
Human Lymphocytes ◽  
Micronucleus Assay

Determination of genotoxic effects of methidathion alkaline hydrolysis in human lymphocytes using the micronucleus assay and square-wave voltammetry

2017 ◽  
Vol 113 ◽  
pp. 9-14 ◽  
Author(s):  
Polychronis D. Stivaktakis ◽  
Evangelos Giannakopoulos ◽  
Dimitris Vlastos ◽  
Demetrios P. Matthopoulos
Keyword(s):  
Alkaline Hydrolysis ◽  
Square Wave Voltammetry ◽  
Human Lymphocytes ◽  
Micronucleus Assay ◽  
Genotoxic Effects ◽  
Square Wave ◽  
Wave Voltammetry

The micronucleus assay in human lymphocytes: screening for inter-individual variability and application to biomonitoring

1994 ◽  
Vol 15 (2) ◽  
pp. 313-317 ◽  
Author(s):  
C.Di Giorgio ◽  
M.P. De Méo ◽  
M. Laget ◽  
H. Guiraud ◽  
A. Botta ◽  
...  
Keyword(s):  
Human Lymphocytes ◽  
Micronucleus Assay ◽  
Individual Variability

scholarly journals Genotoxic evaluation of newly synthesized organometallic compounds of tin

2015 ◽  
Vol 17 (3) ◽  
pp. 574-582
Keyword(s):  
Cytotoxic Effect ◽  
Human Lymphocytes ◽  
Micronucleus Assay ◽  
Organometallic Compounds ◽  
Proliferation Index ◽  
Tripodal Ligands ◽  
Genotoxic Effects

<p>The genotoxic effects of organometallic tin(II) and tin(IV) complexes namely L<sub>OEt</sub>SnCl (<strong>5</strong>), L*<sub>OEt</sub>SnCl (<strong>6</strong>), L<sub>OEt</sub>SnPh<sub>3</sub> (<strong>7</strong>), L*<sub>OEt</sub>SnPh<sub>3</sub> (<strong>8</strong>), incorporating the oxygen tripodal ligands [(<em>η</em><sup>5</sup>-C<sub>5</sub>R<sub>5</sub>)Co{P(OEt)<sub>2</sub>O}<sub>3</sub>]<sup>-</sup>, {R = H, (L<sub>OEt</sub><sup>-</sup>) (<strong>3</strong>); R = Me (L*<sub>OEt</sub><sup>-</sup>) (<strong>4</strong>)} (Klaui type ligands), were investigated using the Cytokinesis Block Micronucleus assay in human lymphocytes cultures. For comparison the precursors NaL<sub>OEt</sub> (<strong>3</strong>), NaL*<sub>OEt</sub> (<strong>4</strong>), SnCl<sub>2</sub>&bull;2H<sub>2</sub>O (<strong>1</strong>) and Ph<sub>3</sub>SnCl (<strong>2</strong>), were also studied.</p> <p>Statistically significant differences in comparison with the control in the micronuclei frequencies were seen at the concentrations: 75 μM for complex (<strong>5</strong>), 50 μM for complex (<strong>6</strong>), 20, 50, 75 μM for complex (<strong>8</strong>). No statistically significant differences were observed between controls and all the rest tested concentrations for all chemicals examined.</p> <div> <p>The cytotoxic effect was evaluated by the Cytokinesis Block Proliferation Index. Regarding this index, the precursor (<strong>1</strong>) is not cytotoxic at all tested concentrations. Complexes (<strong>3</strong>), (<strong>4</strong>) and (<strong>5</strong>) induced cytotoxicity at the concentrations of 20, 50 and 75 μM, while complexes (<strong>6</strong>) and (<strong>8</strong>) were cytotoxic at all tested concentrations. Complex (<strong>7</strong>) was cytotoxic at 5, 10 and 20 μM but extremely toxic at 50 and 75 μM. Finally complex (<strong>2</strong>) was extremely toxic at all tested concentrations except at 1 μM.&nbsp;</p> </div> <p>&nbsp;</p>

An Automated Flow Cytometric Micronucleus Assay for Human Lymphocytes

1992 ◽  
Vol 62 (6) ◽  
pp. 695-709 ◽  
Author(s):  
G.A. Schreiber ◽  
W. Beisker ◽  
H. Braselmann ◽  
M. Bauchinger ◽  
K.W. Bögl ◽  
...  
Keyword(s):  
Human Lymphocytes ◽  
Micronucleus Assay ◽  
Flow Cytometric
Sign in / Sign up

Export Citation Format

Share Document