Effects of mutations at tyrosine 66 and asparagine 123 in the active site pocket of Escherichia coli uracil DNA glycosylase on uracil excision from synthetic DNA oligomers: evidence for the occurrence of long-range interactions between the enzyme and substrate

P. Handa

doi:10.1093/nar/gkf425

Effects of mutations at tyrosine 66 and asparagine 123 in the active site pocket of Escherichia coli uracil DNA glycosylase on uracil excision from synthetic DNA oligomers: evidence for the occurrence of long-range interactions between the enzyme and substrate

Nucleic Acids Research ◽

10.1093/nar/gkf425 ◽

2002 ◽

Vol 30 (14) ◽

pp. 3086-3095 ◽

Cited By ~ 18

Author(s):

P. Handa

Keyword(s):

Escherichia Coli ◽

Long Range ◽

Active Site ◽

Dna Glycosylase ◽

Uracil Dna Glycosylase ◽

Dna Oligomers ◽

Synthetic Dna ◽

Active Site Pocket ◽

Long Range Interactions

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Specificities and kinetics of uracil excision from uracil-containing DNA oligomers by Escherichia coli uracil DNA glycosylase

Biochemistry ◽

10.1021/bi00230a033 ◽

1991 ◽

Vol 30 (16) ◽

pp. 4055-4061 ◽

Cited By ~ 59

Author(s):

Umesh Varshney ◽

Johan H van de Sande

Keyword(s):

Escherichia Coli ◽

Dna Glycosylase ◽

Uracil Dna Glycosylase ◽

Dna Oligomers ◽

Kinetics Of

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Mutational Analysis of the Uracil DNA Glycosylase Inhibitor Protein and Its Interaction with Escherichia coli Uracil DNA Glycosylase

Journal of Molecular Biology ◽

10.1016/s0022-2836(02)00654-x ◽

2002 ◽

Vol 321 (4) ◽

pp. 579-590 ◽

Cited By ~ 9

Author(s):

Narottam Acharya ◽

Sudipta Roy ◽

Umesh Varshney

Keyword(s):

Escherichia Coli ◽

Mutational Analysis ◽

Dna Glycosylase ◽

Inhibitor Protein ◽

Uracil Dna Glycosylase

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Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway

Nucleic Acids Research ◽

10.1093/nar/gkq913 ◽

2010 ◽

Vol 39 (7) ◽

pp. 2593-2603 ◽

Cited By ~ 12

Author(s):

Seden Grippon ◽

Qiyuan Zhao ◽

Tom Robinson ◽

Jacqueline J. T. Marshall ◽

Rory J. O’Neill ◽

...

Keyword(s):

Escherichia Coli ◽

Dna Binding ◽

Base Excision Repair ◽

Excision Repair ◽

Dna Glycosylase ◽

Repair Pathway ◽

Uracil Dna Glycosylase ◽

Base Excision Repair Pathway ◽

Base Excision

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3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.95.15.8508 ◽

1998 ◽

Vol 95 (15) ◽

pp. 8508-8513 ◽

Cited By ~ 111

Author(s):

M. Saparbaev ◽

J. Laval

Keyword(s):

Escherichia Coli ◽

Dna Glycosylase ◽

Uracil Dna Glycosylase ◽

Thymine Dna Glycosylase ◽

Primary Substrate

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ROLES OF URACIL-DNA GLYCOSYLASE AND APYRIMIDINIC ENDONUCLEASES IN THE MOLECULAR 5-BROMO-2'-DEOXYURIDINE PHOTOSENSITIZATION IN Escherichia coli K-12

Photochemistry and Photobiology ◽

10.1111/j.1751-1097.1993.tb04905.x ◽

1993 ◽

Vol 58 (1) ◽

pp. 66-70

Author(s):

Yoko Yamamoto ◽

Yoshisada Fujlwarat

Keyword(s):

Escherichia Coli ◽

Dna Glycosylase ◽

Uracil Dna Glycosylase ◽

K 12

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Specific mutator effects of ung (uracil-DNA glycosylase) mutations in Escherichia coli.

Journal of Bacteriology ◽

10.1128/jb.151.2.750-755.1982 ◽

1982 ◽

Vol 151 (2) ◽

pp. 750-755 ◽

Cited By ~ 100

Author(s):

B K Duncan ◽

B Weiss

Keyword(s):

Escherichia Coli ◽

Dna Glycosylase ◽

Uracil Dna Glycosylase

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Early events after infection of Escherichia coli by bacteriophage T5. III. Inhibition of uracil-DNA glycosylase activity.

Journal of Virology ◽

10.1128/jvi.33.1.535-538.1980 ◽

1980 ◽

Vol 33 (1) ◽

pp. 535-538 ◽

Cited By ~ 19

Author(s):

H R Warner ◽

L K Johnson ◽

D P Snustad

Keyword(s):

Escherichia Coli ◽

Dna Glycosylase ◽

Uracil Dna Glycosylase ◽

Bacteriophage T5

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Mutations in active-site residues of the uracil-DNA glycosylase encoded by vaccinia virus are incompatible with virus viability.

Journal of Virology ◽

10.1128/jvi.70.11.7965-7973.1996 ◽

1996 ◽

Vol 70 (11) ◽

pp. 7965-7973 ◽

Cited By ~ 28

Author(s):

K S Ellison ◽

W Peng ◽

G McFadden

Keyword(s):

Vaccinia Virus ◽

Active Site ◽

Dna Glycosylase ◽

Active Site Residues ◽

Uracil Dna Glycosylase

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Mechanism of translocation of uracil–DNA glycosylase from Escherichia coli between distributed lesions

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2011.09.106 ◽

2011 ◽

Vol 414 (2) ◽

pp. 425-430 ◽

Cited By ~ 9

Author(s):

Grigory V. Mechetin ◽

Dmitry O. Zharkov

Keyword(s):

Escherichia Coli ◽

Dna Glycosylase ◽

Uracil Dna Glycosylase

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Structure of Escherichia coli uracil-DNA glycosylase and its complexes with nonhydrolyzable substrate analogues in solution studied by synchrotron small-angle X-ray scattering

BIOPHYSICS ◽

10.1134/s0006350906010015 ◽

2006 ◽

Vol 51 (1) ◽

pp. 1-7

Author(s):

A. A. Timchenko ◽

E. A. Kubareva ◽

E. M. Volkov ◽

O. L. Voronina ◽

V. G. Lunin ◽

...

Keyword(s):

Escherichia Coli ◽

Small Angle ◽

Dna Glycosylase ◽

Uracil Dna Glycosylase ◽

X Ray ◽

X Ray Scattering ◽

Substrate Analogues ◽

Ray Scattering

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