scholarly journals jPREdictor: a versatile tool for the prediction of cis-regulatory elements

2006 ◽  
Vol 34 (Web Server) ◽  
pp. W546-W550 ◽  
Author(s):  
T. Fiedler ◽  
M. Rehmsmeier
Keyword(s):  
Regulatory Elements ◽  
Versatile Tool

scholarly journals cLoops2: a full-stack comprehensive analytical tool for chromatin interactions

2021 ◽  
Author(s):  
Yaqiang Cao ◽  
Shuai Liu ◽  
Gang Ren ◽  
Qingsong Tang ◽  
Keji Zhao
Keyword(s):  
Gene Expression Regulation ◽  
Regulatory Elements ◽  
Chromatin Interaction ◽  
Similarity Estimation ◽  
Chromatin Interactions ◽  
Data Similarity ◽  
Sequencing Cost ◽  
Versatile Tool ◽  
Resolution Estimation ◽  
Aggregation Analysis

Investigating chromatin interactions between regulatory regions such as enhancer and promoter elements is vital for a deeper understanding of gene expression regulation. The emerging 3D mapping technologies focusing on enriched signals such as Hi-TrAC/TrAC-looping, compared to Hi-C and variants, reduce the sequencing cost and provide higher interaction resolution for cis-regulatory elements. A robust pipeline is needed for the comprehensive interpretation of these data, especially for loop-centric analysis. Therefore, we have developed a new versatile tool named cLoops2 for the full-stack analysis of the 3D chromatin interaction data. cLoops2 consists of core modules for peak-calling, loop-calling, differentially enriched loops calling and loops annotation. Additionally, it also contains multiple modules to carry out interaction resolution estimation, data similarity estimation, features quantification and aggregation analysis, and visualization. cLoops2 with documentation and example data are open source and freely available at GitHub: https://github.com/YaqiangCao/cLoops2.

Hungarian small business tax and possibilities to minimize distortions from capital income taxation

2015 ◽  
Vol 37 (s1) ◽  
pp. 87-105
Author(s):  
Benedek Nobilis ◽  
András Svraka
Keyword(s):  
Small Business ◽  
Cash Flow ◽  
Capital Accumulation ◽  
Value Added ◽  
Regulatory Elements ◽  
Capital Income ◽  
Potential Growth ◽  
Elegant Method ◽  
Business Tax ◽  
Working Out

Governments throughout the EU and OECD countries rely on revenues raised on capital income. Albeit several arguments can be made for keeping these taxes, in their widespread form they hinder capital accumulation and significantly lower potential growth due to their savings and investment distorting nature. At the same time, the actual economic impact of tax types is largely influenced by their structure. An elegant method, which is also simple in its concept, for eliminating the economic distortions of profit taxes is cash-flow taxation which moves income taxes closer to the more growth-friendly value-added taxes. The small business tax, which was introduced in Hungary in 2013, was designed along these principles. In this paper we review the theoretical literature on cash-flow taxation and discuss the main regulatory elements of the small business tax, as well as the solutions elaborated for working out the challenges related to its implementation.

CRUCIBLE S7

Alloy Digest ◽  
1996 ◽  
Vol 45 (7) ◽  
Keyword(s):  
Heat Treatment ◽  
Fracture Toughness ◽  
Physical Properties ◽  
Tool Steel ◽  
Cold Work ◽  
Heat Treating ◽  
High Shock ◽  
Unusual Combination ◽  
Versatile Tool ◽  
Shock Resistance

Abstract Crucible S7 is a chromium/molybdenum tool steel developed to produce the unusual combination of high shock resistance and toughness together with ease of machining and heat treatment. It is a versatile tool steel applicable for both hot and cold work shock applications. This datasheet provides information on composition, physical properties, hardness, and elasticity as well as fracture toughness. It also includes information on heat treating, machining, and joining. Filing Code: TS-543. Producer or source: Crucible Service Centers.

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