scholarly journals Effect of Locked Nucleic Acid (LNA) modification on Hybridization Kinetics of DNA duplex

2008 ◽  
Vol 52 (1) ◽  
pp. 417-418 ◽  
Author(s):  
A. Arora ◽  
H. Kaur ◽  
J. Wengel ◽  
S. Maiti
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid ◽  
Dna Duplex ◽  
Kinetics Of

Novel nucleic acid architectures involving locked nucleic acid (LNA) and pyrene residues: Results from an Indo-Danish collaboration

2005 ◽  
Vol 77 (1) ◽  
pp. 319-326 ◽  
Author(s):  
B. Ravindra Babu ◽  
Mads D. Sørensen ◽  
Patrick J. Hrdlicka ◽  
Smriti Trikha ◽  
Ashok K. Prasad ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Dna Synthesis ◽  
Surface Area ◽  
Locked Nucleic Acid ◽  
Planar Surface ◽  
Dna Duplex ◽  
Fluorescent Tag ◽  
Conformationally Locked ◽  
Covalently Bound

We report herein our results for locked nucleic acid (LNA)-type oligonucleotides containing pyrene residues. Pyrene has a large hydrophobic and planar surface area and is therefore a potential intercalating unit; furthermore, it is interesting as a fluorescent tag when covalently bound to DNA. Synthesis and hybridization of conformationally locked universal base surrogates are described together with efficient interstrand communication as shown by the formation of pyrene excimer bands for duplexes containing 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers positioned in a zipper-like manner within a DNA duplex.

Sequence-Dependent Thermodynamic Parameters for Locked Nucleic Acid (LNA)−DNA Duplex Formation†

Biochemistry ◽  
2004 ◽  
Vol 43 (18) ◽  
pp. 5388-5405 ◽  
Author(s):  
Patricia M. McTigue ◽  
Raymond J. Peterson ◽  
Jason D. Kahn
Keyword(s):  
Nucleic Acid ◽  
Thermodynamic Parameters ◽  
Locked Nucleic Acid ◽  
Dna Duplex ◽  
Sequence Dependent ◽  
Duplex Formation

Trinucleotide Cap Analogue Bearing a Locked Nucleic Acid Moiety: Synthesis, mRNA Modification, and Translation for Therapeutic Applications

2021 ◽  
Author(s):  
Annamalai Senthilvelan ◽  
Tyson Vonderfecht ◽  
Muthian Shanmugasundaram ◽  
Indra Pal ◽  
Jason Potter ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid ◽  
Acid Moiety ◽  
Therapeutic Applications

Solution Structure of a Locked Nucleic Acid Modified Quadruplex: Introducing the V4 Folding Topology

2009 ◽  
Vol 121 (17) ◽  
pp. 3145-3149 ◽  
Author(s):  
Jakob T. Nielsen ◽  
Khalil Arar ◽  
Michael Petersen
Keyword(s):  
Nucleic Acid ◽  
Solution Structure ◽  
Locked Nucleic Acid

i-Motif Formation with Locked Nucleic Acid (LNA)

2007 ◽  
Vol 119 (48) ◽  
pp. 9380-9382 ◽  
Author(s):  
Niti Kumar ◽  
Jakob T. Nielsen ◽  
Souvik Maiti ◽  
Michael Petersen
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid

A Locked Nucleic Acid-Based Nanocrawler: Designed and Reversible Movement Detected by Multicolor Fluorescence

2013 ◽  
Vol 135 (7) ◽  
pp. 2423-2426 ◽  
Author(s):  
I. Kira Astakhova ◽  
Karol Pasternak ◽  
Meghan A. Campbell ◽  
Pankaj Gupta ◽  
Jesper Wengel
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid ◽  
Multicolor Fluorescence
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