scholarly journals Urinary albumin excretion rate and glomerular filtration rate in the prediction of diabetic nephropathy; a long‐term follow‐up study of childhood onset type‐1 diabetic patients

2001 ◽  
Vol 16 (7) ◽  
pp. 1382-1386 ◽  
Author(s):  
Gisela Dahlquist ◽  
Eva‐Lena Stattin ◽  
Susanne Rudberg
Keyword(s):  
Urinary Albumin Excretion ◽  
Excretion Rate ◽  
Albumin Excretion Rate ◽  
Diabetic Patients ◽  
Childhood Onset ◽  
Long Term Follow Up ◽  
Type 1 Diabetic Patients

Long-term follow-up of diabetic polyneuropathy after simultaneous pancreas and kidney transplantation in type 1 diabetic patients

2002 ◽  
Vol 34 (1) ◽  
pp. 200-203 ◽  
Author(s):  
M Recasens ◽  
M.J Ricart ◽  
J Valls-Solé ◽  
A Caballero ◽  
L Fernández-Cruz ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Diabetic Polyneuropathy ◽  
Diabetic Patients ◽  
Long Term Follow Up ◽  
Type 1 Diabetic Patients

scholarly journals Long-term mortality in a nationwide cohort of childhood-onset type 1 diabetic patients in Norway

Diabetologia ◽  
2005 ◽  
Vol 49 (2) ◽  
pp. 298-305 ◽  
Author(s):  
T. Skrivarhaug ◽  
H.-J. Bangstad ◽  
L. C. Stene ◽  
L. Sandvik ◽  
K. F. Hanssen ◽  
...  
Keyword(s):  
Diabetic Patients ◽  
Childhood Onset ◽  
Onset Type ◽  
Type 1 Diabetic Patients ◽  
Long Term Mortality

scholarly journals An IGF-I gene polymorphism modifies the risk of developing persistent microalbuminuria in type 1 diabetes

2007 ◽  
Vol 156 (1) ◽  
pp. 83-90 ◽  
Author(s):  
Peter Hovind ◽  
Steven Lamberts ◽  
Wim Hop ◽  
Jaap Deinum ◽  
Lise Tarnow ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Gene Polymorphism ◽  
Urinary Albumin Excretion ◽  
Excretion Rate ◽  
Albumin Excretion Rate ◽  
Wild Type ◽  
Variant Type ◽  
Igf I

Objective: Derangements of the GH–IGF-I axis have been associated with microalbuminuria (MA) in type 1 diabetes. The aim of this study was to investigate whether an IGF-I gene promoter polymorphism influenced the development of persistent MA in type 1 diabetes. Design: A prospective follow-up study of a cohort of 277 patients with newly diagnosed type 1 diabetes consecutively enrolled between September 1979 and August 1984. Methods: Urinary albumin excretion rate over 24 h was measured in each patient at least once a year. Persistent MA was defined as a urinary albumin excretion rate between 30 and 300 mg/24 h. Results: During a median follow-up of 18.0 years (range 1.0–21.5), 79 of 277 patients developed persistent MA. IGF-I gene genotype was available for 216 subjects; in 73% of the subjects, the wild-type genotype of this IGF-I gene polymorphism was present, while 27% had the variant type. At baseline, there were no differences in IGF-I levels and HbA1c values between subjects with the wild type and subjects with variant type. By Kaplan–Meier analysis, subjects with the variant type of this polymorphism had during follow-up a higher risk of development of MA compared subjects with the wild type (P = 0.03). Conclusions: Subjects with the variant type of an IGF-I gene polymorphism had a significantly increased risk of developing MA. This risk was not mediated through changes in circulating IGF-I levels. Our study suggests that in type 1 diabetes, this IGF-I gene polymorphism is a risk factor of MA.

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