scholarly journals P1409HIP FRACTURE TRENDS IN SWEDISH GENERAL POPULATION AND DIALYSIS PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Ken Iseri ◽  
Juan Jesus Carrero ◽  
Marie Evans ◽  
Li Felländer-Tsai ◽  
Hans Berg ◽  
...  

Abstract Background and Aims Hip fracture incidence rate is higher in dialysis patients than in general population. We investigated and compared temporal changes in age-standardized hip fracture incidence rate (ASRhip fracture) 2007-2016 in men and women in the dialysis population and in the general population. Method We used the population-based Swedish national database of fractures and the Swedish Renal Registry of ESRD patients to retrieve data on ASRhip fracture in the general population and among dialysis patients. The average annual percent change of the hip fracture incidence trend was evaluated by join-point regression analysis according to gender in the two databases. Results ASRhip fracture was about three times higher in Swedish dialysis patients as compared to the Swedish general population. In dialysis patients, rates have steadily declined during the recent decade when assessed in both sexes combined, and when analysed in women and men separately. A similar trend was also seen in the general population; however, the rate of decline was steeper in dialysis patients than in the general population. The most recent data on ASRhip fracture (for 2016) show that ASRhip fracture was similar among female and male dialysis patients whereas ASRhip fracture in the general population was higher in women than in men. Conclusion Hip fracture incidence is declining in the general population and even more so in dialysis patients. In contrast to the general population where hip fracture incidence in 2016 is higher among women than in men, there was no such difference between the two sexes among dialysis patients.

Bone ◽  
2021 ◽  
Vol 147 ◽  
pp. 115909
Author(s):  
Ken Iseri ◽  
Juan Jesús Carrero ◽  
Marie Evans ◽  
Björn Runesson ◽  
Peter Stenvinkel ◽  
...  

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249819
Author(s):  
Sangsoo Han ◽  
Hae-Dong Jang ◽  
Sangun Nah ◽  
Kyungdo Han ◽  
Hyunwoong Lim ◽  
...  

Objective Hip fracture incidence is increasing with rapid aging of the population and regular physical activity (RPA) is an important modifiable protective factor for fracture. However, the association between the risk of hip fractures and changes in RPA status in the general population remains unknown. Thus, we explore the association between the risk of hip fracture and changes in RPA status. Methods We studied 4,984,144 individuals without fractures within a year whose data were registered in the Korean National Health Insurance Service database. Baseline physical activity level was assessed using a standardized self-reported questionnaire during two consecutive national health screening surveys performed in Korea from 2009 to 2012. The risk of hip fracture between 2013 and 2016 according to change in RPA was prospectively analyzed. Participants were divided into those who were always inactive, became inactive, became active, and were always active. Results Compared to participants who were always inactive, those who became inactive exhibited a 0.12/1,000 person-years (PY) reduction in hip fracture incidence rate (IR) [aHR: 0.865; 95% confidence interval (CI): 0.824–0.908]. Participants who became active, and those who were always active, exhibited a 0.24/1,000 PY reduction in IR (aHR: 0.827; 95% CI: 0.787–0.870) and a 0.39/1,000 PY reduction in IR (aHR: 0.691; 95% CI: 0.646–0.740), respectively. Conclusion Changes in RPA status were associated with the risk of hip fracture; consistent RPA was related to the maximum benefit for risk reduction in the general population.


2007 ◽  
Vol 19 (8) ◽  
pp. 1139-1145 ◽  
Author(s):  
A. Icks ◽  
B. Haastert ◽  
M. Wildner ◽  
C. Becker ◽  
G. Meyer

1990 ◽  
Vol 80 (7) ◽  
pp. 871-873 ◽  
Author(s):  
S J Jacobsen ◽  
J Goldberg ◽  
T P Miles ◽  
J A Brody ◽  
W Stiers ◽  
...  

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
S. Issayeva ◽  
O. Lesnyak ◽  
A. Zakroyeva ◽  
B. Issayeva ◽  
D. Dilmanova ◽  
...  

Abstract Summary Retrospective and prospective population-based survey in a region of the Republic of Kazakhstan determined the incidence of fractures at the hip, proximal humerus and distal forearm. The hip fracture rates were used to create a FRAX® model to enhance fracture risk assessment in Kazakhstan. Objective This paper describes the epidemiology of osteoporotic fractures in the Republic of Kazakhstan that was used to develop a country specific FRAX® tool for fracture prediction. Methods We carried out a retrospective population-based survey in Taldykorgan in the Republic of Kazakhstan representing approximately 1% of the country’s population. Hip, forearm and humerus fractures were identified retrospectively in 2015 and 2016 from hospital registers and the trauma centre. Hip fractures were prospectively identified in 2017 from the same sources and additionally from primary care data. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Kazakhstan. Fracture probabilities were compared with those from neighbouring countries having FRAX models. Results The difference in hip fracture incidence between the retrospective and prospective survey indicated that approximately 25% of hip fracture cases did not come to hospital attention. The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 11,690 and is predicted to increase by 140% to 28,000 in 2050. Hip fracture incidence was a good predictor of forearm and humeral fractures in men but not in women. Conclusion The FRAX model should enhance accuracy of determining fracture probability among the Kazakh population and help guide decisions about treatment.


2016 ◽  
Vol 61 (9) ◽  
pp. 1021-1030 ◽  
Author(s):  
Hans Concin ◽  
Wolfgang Brozek ◽  
Karl-Peter Benedetto ◽  
Hartmut Häfele ◽  
Joachim Kopf ◽  
...  

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Ken Iseri ◽  
Juan Jesus Carrero ◽  
Marie Evans ◽  
Li Felländer-Tsai ◽  
Hans Berg ◽  
...  

Abstract Background and Aims The incidence of fractures is markedly higher in dialysis patients than in pre-dialysis patients, but it is not clear to what extent the initiation of dialysis as such is associated with accelerated fracture incidence or if fracture rates are already increasing prior to dialysis start among incident dialysis patients. Here we investigated the temporal pattern of occurrence of a first major osteoporotic fracture (MOF) among incident dialysis patients in the pre-dialysis period and in the period following dialysis initiation. Method We analyzed data from Swedish Renal Registry (SRR) and identified 9041 incident dialysis patients (2005 -2015; age 67 years, 67% men). We identified all first MOF (MOFfirst) in hip, spine, humerus and forearm during 12 months before and after dialysis initiation. Using flexible parametric hazard models and Fine-Gray analysis accounting for competing risk of death and renal transplantation, we estimated adjusted fracture incidence rates and predictors of MOFfirst. Results During the whole follow-up period, there were 361 fractures including 196 hip fractures. The crude incidence rate of MOFfirst (n=157) before dialysis initiation was 17/1000 patient-years and after initiation of dialysis the incidence rate of MOFfirst increased to 24/1000 patient-years. Overall the adjusted MOFfirst incidence rates increased from 6 months before initiation of dialysis, fluctuated, and stabilized at a higher rate than that of the baseline rate after 12 months. The adjusted hip fracture rate rose steeply 3 months before dialysis initiation, declined 3 months after dialysis initiation, fluctuated, and then became stabilized. On the contrary, the adjusted incidence rates of other fractures, i.e., non-hip fractures, appeared to be stable all the time, before as well as after initiation of dialysis. Female gender, higher age and previous history of MOF had a negative impact on fracture incidence rates before and after dialysis initiation. Conclusion We conclude that the incidence of MOFfirst is increasing already from 6 months prior to dialysis initiation among incident dialysis patients, and that there is a further increase following dialysis initiation. For hip fracture, which was the most common MOF, the temporal pattern of incidence rates was compressed to a high risk period lasting from 3 months before to 3 months after dialysis initiation, underlining the need of increased attention to prevent hip fractures in incident dialysis patients during this critical period.


2012 ◽  
Vol 24 (1) ◽  
pp. 373-376 ◽  
Author(s):  
A. L. Adams ◽  
J. Shi ◽  
M. Takayanagi ◽  
R. M. Dell ◽  
T. T. Funahashi ◽  
...  

2021 ◽  
pp. svn-2020-000809
Author(s):  
Sung Soo Ahn ◽  
Minkyung Han ◽  
Yong-Beom Park ◽  
Inkyung Jung ◽  
Sang-Won Lee

BackgroundTakayasu arteritis (TAK) is a disease associated with increased risk of cardiovascular complications. We aimed to evaluate the incidence, prevalence and risk of stroke in patients with TAK.MethodsData from 1065 patients were obtained from a national database (2010–2018). The annual incidence and prevalence per 100 000 persons were estimated using the registration population in the midst of every year, and the standardised incidence ratio (SIR) of stroke was compared with the general population based on the data from the 2006 national report for cardiovascular and cerebrovascular diseases. Age-adjusted incidence rate ratio (IRR) of stroke based on the time interval after diagnosis was also calculated. A time-dependent Cox regression was conducted to investigate predictive factors of stroke.ResultsThe overall incidence rate of TAK ranged between 0.2 and 0.3/100 000 person-years annually; the prevalence of TAK gradually increased, reaching 3.25/100 000 person-years in 2018. Seventy-three (6.9%) patients experienced stroke during follow-up, and the risk of developing stroke was higher than the general population (overall SIR 7.39, 95% CI 5.79 to 9.29; men: SIR 5.70, 95% CI 2.84 to 10.20; women: SIR 7.06, 95% CI 5.41 to 9.05). Most stroke events (90.9%) were cerebral infarction for men, whereas the proportion of cerebral infarction was lower (62.9%) in women. Over half of stroke events occurred within 6 months after diagnosis, and stroke was more common within 6 months of diagnosis compared with after 3 years in women (IRR 13.46, 95% CI 6.86 to 26.40). In Cox regression analysis, age was the sole predictor of stroke (adjusted HR 1.02, 95% CI 1.00 to 1.04, p=0.043).ConclusionsThe annual incidence of TAK was similar to the previous studies from Asia, and the risk of stroke increased in TAK. Different patterns of subtype and incidence of stroke were found according to sex, although age was the only predictor.


Sign in / Sign up

Export Citation Format

Share Document