scholarly journals Dynamic susceptibility contrast MRI measures of relative cerebral blood volume continue to show promise as an early response marker in the setting of bevacizumab treatment

2015 ◽  
Vol 17 (11) ◽  
pp. 1538-1539 ◽  
Author(s):  
Jerrold L. Boxerman ◽  
Kathleen M. Schmainda ◽  
Zheng Zhang ◽  
Daniel P. Barboriak
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Early Response ◽  
Dynamic Susceptibility ◽  
Dynamic Susceptibility Contrast ◽  
Relative Cerebral Blood Volume ◽  
Dynamic Susceptibility Contrast Mri ◽  
Bevacizumab Treatment ◽  
Susceptibility Contrast

scholarly journals Integrative Analysis of mRNA, microRNA, and Protein Correlates of Relative Cerebral Blood Volume Values in GBM Reveals the Role for Modulators of Angiogenesis and Tumor Proliferation

2016 ◽  
Vol 15 ◽  
pp. CIN.S33014 ◽  
Author(s):  
Arvind Rao ◽  
Ganiraju Manyam ◽  
Ganesh Rao ◽  
Rajan Jain
Keyword(s):  
Blood Volume ◽  
Messenger Rna ◽  
Cerebral Blood Volume ◽  
The Cancer Genome Atlas ◽  
Dynamic Susceptibility ◽  
Tumor Proliferation ◽  
Dynamic Susceptibility Contrast ◽  
Relative Cerebral Blood Volume ◽  
Hemodynamic Assessment ◽  
Susceptibility Contrast

Dynamic susceptibility contrast-enhanced magnetic resonance imaging is routinely used to provide hemodynamic assessment of brain tumors as a diagnostic as well as a prognostic tool. Recently, it was shown that the relative cerebral blood volume (rCBV), obtained from the contrast-enhancing as well as -nonenhancing portion of glioblastoma (GBM), is strongly associated with overall survival. In this study, we aim to characterize the genomic correlates (microRNA, messenger RNA, and protein) of this vascular parameter. This study aims to provide a comprehensive radiogenomic and radioproteomic characterization of the hemodynamic phenotype of GBM using publicly available imaging and genomic data from the Cancer Genome Atlas GBM cohort. Based on this analysis, we identified pathways associated with angiogenesis and tumor proliferation underlying this hemodynamic parameter in GBM.

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