Surgical treatment of patients with defects of the middle cranial fossa complicated by meningoencephalic herniation, with various ear pathologies, is an important problematic issue at the intersection of two disciplines – otorhinolaryngology and neurosurgery. The issues of etiology and pathogenesis of bone formation in defects of the middle cranial fossa and the methods of surgical treatment of patients with bone defects of the middle cranial fossa complicated by meningoencephalic herniation of the temporal bone. The analysis of the causes of recurrence of the disease with the use of certain techniques was carried out, and based on this, an improved technique for multilayer plastics of a bone defect of the middle cranial fossa through a combined approach (behind the ear (BTE) transmastoid + infratemporal minicraniotomy) using autotissues, biocomposite materials, and adhesive components was developed and described. Evaluated performance criteria for all treated patients were: absence of recurrence of hernia formation of shells and substances of the brain in the middle ear cavity and the absence of otorrhea. All the operated patients with defects of the middle cranial fossa and meningoencephalocele of the temporal bone were followed up from 1 to 5 years. Preliminary analysis of the results of treatment of patients using the improved method showed its high efficiency, which is confirmed by the absence of disease recurrence. On this basis, the main conclusions are formulated and a brief algorithm of surgical tactics for the closure of bone defects of the middle cranial fossa of various sizes is presented.