Effectiveness of Varenicline versus Combination Nicotine Replacement Therapy for Smoking Cessation: One Year Outcomes in a Smoking Cessation Clinic in Taiwan

2021 ◽  
Author(s):  
Kuang-Chieh Hsueh ◽  
Pei-Ling Tang ◽  
Hayden McRobbie
Keyword(s):  
Smoking Cessation ◽  
Meta Analysis ◽  
Primary Outcome Measure ◽  
Abstinence Rate ◽  
Nicotine Replacement ◽  
Quit Attempt ◽  
Replacement Treatment ◽  
Long Term Follow Up ◽  
Cessation Clinic ◽  
Smoking Cessation Clinic

Abstract Introduction Varenicline and combination nicotine replacement treatment (cNRT) have been recommended as the most effective pharmacotherapies, with equal abstinence rate for smoking cessation in a network meta-analysis of randomized trials, but data from real-world long-term follow-up studies are rare. This study aimed to compare the 12-month sustained abstinence rates of smokers using varenicline versus cNRT in their quit attempt. Methods A total of 3,569 smokers were recruited via the Department of Family Medicine outpatient department at Kaohsiung Veteran General Hospital between June 2013 and March 2019. Participants received counseling from a physician and chose either varenicline (N=2,870) or cNRT (N=699) for smoking cessation. Both varenicline and cNRT users could receive a free 8-week supply and 8 clinic visits over 90 days. Participants were followed-up by telephone at 12, 24, and 52 weeks from first visit. The primary outcome measure of the study was self-reported sustained abstinence up to 52 weeks. Results Varenicline users had a significantly higher sustained abstinence rate weeks 12-52, adjusted for baseline variables (15.2% vs. 10.3%, p=0.001; aOR= 1.47, 95%CI: 1.05–2.05). Other significant predictors of 52 weeks sustained abstinence were being male, having a higher income, attending more clinical visits and have lower nicotine dependence. Conclusion Varenicline appears to have higher sustained abstinence rates to 52 weeks compared with cNRT, in a smoking cessation clinic where smokers can choose their medication option.

scholarly journals Effectiveness of pharmacologic therapies on smoking cessation success: three years results of a smoking cessation clinic

2014 ◽  
Vol 9 ◽  
Author(s):  
Elif Yilmazel Ucar ◽  
Omer Araz ◽  
Nafiye Yilmaz ◽  
Metin Akgun ◽  
Mehmet Meral ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Replacement Therapy ◽  
Nicotine Replacement Therapy ◽  
Relapse Rate ◽  
Pharmacologic Therapy ◽  
Nicotine Replacement ◽  
One Year ◽  
Pharmacologic Therapies ◽  
Cessation Clinic ◽  
Smoking Cessation Clinic

Background: Pharmacologic therapies have an important role in the success of interventions for smoking cessation. This study aims to determine the efficacy of several pharmacologic treatments in patients who applied to a smoking cessation clinic. Methods: This retrospective study includes 422 patients who presented to our smoking cessation clinic between January 2010 and June 2013, used the pharmacologic treatment as prescribed and completed the one-year follow-up period. All patients were assessed using the Fagerström Test for Nicotine Dependence (FTND) and received both behavioral therapy and pharmacotherapy. Patients’ smoking status at one year was assessed by telephone interview. Results: The patients were 24.3% female (103/422) and 75.7% male (319/422) with a mean age of 38 ± 10 years. Patients were divided into three groups: varenicline (166 patients), bupropion (148 patients) and nicotine replacement therapy (108 patients).  The smoking cessation rates of these groups were 32.5%, 23% and 52.8%, respectively, and were statistically significant (p < 0.001). The overall success rate was 35%. Further analysis revealed that pharmacologic therapy (p < 0.001) and gender (p = 0.01) were factors that showed statistically significant effects on smoking cessation rates. Males had higher success rates than females. The overall relapse rate was 21.6% and the bupropion group showed the highest relapse rate among treatment groups. Lack of determination emerged as the most important factor leading to relapse. Conclusion: Nicotine replacement therapy was found to be more effective at promoting abstinence from smoking than other pharmacologic therapies.

scholarly journals Government’s subsidisation policy and utilisation of smoking cessation treatments: a population-based cross-sectional study in Taiwan

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e040424
Author(s):  
Sheng-Kuang Wang ◽  
Chi-Wen Kao ◽  
Hui-Wan Chuang ◽  
Yi-Kai Tseng ◽  
Wan-Chun Chen ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Primary Outcome ◽  
Outcome Measure ◽  
Primary Outcome Measure ◽  
Cross Sectional ◽  
Quit Smoking ◽  
Combined Use ◽  
Heavy Smokers ◽  
Cessation Clinic ◽  
Smoking Cessation Clinic

ObjectivesThis study examined the associations between the Second-Generation Cessation Payment Scheme (SCPS) and the use of smoking cessation treatments. Furthermore, these associations were compared between light and heavy smokers in Taiwan.DesignThis study had a cross-sectional design.SettingData were obtained from the Taiwan Adult Smoking Behaviour Surveillance System 2010–2011 and 2013–2014; data for each year consisted of a nationally representative sample of adults aged 18 years and older.ParticipantsCurrent smokers who had either quit or made a serious attempt to quit smoking were selected for the analysis.Primary outcome measureThe primary outcome measure was the use of a smoking cessation clinic or pharmacy in a twice daily to quit smoking.ResultsAccording to multivariate analysis, the SCPS was positively associated with the combined use of a smoking cessation clinic and a pharmacy (OR=3.947; 95% CI: 1.359 to 11.463) when individual-level predictors (gender, age, education level, marital status, monthly household income, daily cigarette consumption, smoking status and self-reported health) were controlled. Heavy smokers showed a significant increase in the sole use of a pharmacy (OR=1.676; 95% CI: 1.094 to 2.569) and combined use of a smoking cessation clinic and pharmacy (OR=8.984; 95% CI: 1.914 to 42.173) after the SCPS was introduced. In addition, when related factors were controlled, the use of smoking cessation services was more frequent among heavy smokers than light smokers, including any treatment (OR=1.594; 95% CI: 1.308 to 1.942), a smoking cessation clinic (OR=1.539; 95% CI: 1.232 to 1.922), a pharmacy (OR=1.632; 95% CI: 1.157 to 2.302) and the combination of a smoking cessation clinic and pharmacy (OR=4.608; 95% CI: 1.331 to 15.949) .ConclusionsThe SCPS subsidisation policy increased the use of smoking cessation treatments, particularly among heavy smokers.

Meta-analysis on efficacy of nicotine replacement therapies in smoking cessation

The Lancet ◽  
1994 ◽  
Vol 343 (8890) ◽  
pp. 139-142 ◽  
Author(s):  
C. Silagy ◽  
D. Mant ◽  
G. Fowler ◽  
M. Lodge
Keyword(s):  
Smoking Cessation ◽  
Meta Analysis ◽  
Nicotine Replacement

scholarly journals Characteristics and Predictors of Abstinence Among Smokers of a Smoking Cessation Clinic in Hunan China

2021 ◽  
Vol 9 ◽  
Author(s):  
Yina Hu ◽  
Jianghua Xie ◽  
Xiaochang Chang ◽  
Jianhua Chen ◽  
Wei Wang ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Statistical Significance ◽  
Operational Experience ◽  
Individual Counseling ◽  
Quit Smoking ◽  
Binary Regression Analysis ◽  
Counseling And Assessment ◽  
Cessation Clinic ◽  
Smoking Cessation Clinic

Background: More than 300 million smokers make China the largest cigarette consumer globally, which is a huge economic burden. Smoking cessation (SC) clinics can offer counseling and follow-up services. The operational experience of SC clinics in China needs to be summarized and improved based on research evidence.Purpose: The objectives of this study were to describe quit rates among attendees of SC clinics in Hunan and assess predictors of successful SC.Methods: The participants in this study were smokers who visited the SC clinic of Hunan Cancer Hospital from February 1, 2015 to September 30, 2018. Individuals who received individual counseling and assessment from the SC clinic staff and were willing to quit smoking were eligible for inclusion. Those with critical illness or cancer were excluded. Application of smoking cessation clinic registration form (unified by Chinese Center for Disease Control and Prevention) was used to assess participants at the consultation. Follow-ups and counseling were performed over telephone at 1 week, 1 month, and 3 months after the initial cessation consultation or in times of need. Successful SC was checked for at 3 months after the start of SC.Results: A total of 328 smokers (mean age 45.67 ± 12.38 years) had participated. The abstinence rate at 3 months was 28.4%. Binary regression analysis revealed significant independent predictors to be the total numbers of SC follow up sessions, previous SC attempts, and participants' decision on when to quit smoking (The relative to quit immediately group, quit within 30 days, quit after 30 days, and undecided quit were less likely to succeed in quitting. while quit within seven days had no statistical significance.Conclusion: SC clinics can achieve a desirably high quit rate. Participant's previous attempts at quitting, three or more follow-ups, and the decision to quit immediately or within seven days were factors helpful in predicting the success of SC.

scholarly journals Factors affecting success and abstinence within a smoking cessation clinic: A one-year follow-up study in Turkey

2020 ◽  
Vol 6 (December) ◽  
pp. 1-8
Author(s):  
Ayse Esen ◽  
Yuksel Soylem ◽  
Secil Arica ◽  
Gulten Belgin ◽  
Nadire Gonultas
Keyword(s):  
Smoking Cessation ◽  
Factors Affecting ◽  
Follow Up Study ◽  
One Year ◽  
Cessation Clinic ◽  
Smoking Cessation Clinic

scholarly journals Does Short Message Service Increase Adherence to Smoking Cessation Clinic Appointments and Quitting Smoking?

2016 ◽  
Vol 33 (5) ◽  
pp. 525-531 ◽  
Author(s):  
Seda Tural Onur ◽  
Mehmet Atilla Uysal ◽  
Sinem Iliaz ◽  
Sibel Yurt ◽  
Ayse Bahadir ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Short Message Service ◽  
Short Message ◽  
Quitting Smoking ◽  
Message Service ◽  
Cessation Clinic ◽  
Smoking Cessation Clinic

Predictors of success in a smoking cessation clinic

1996 ◽  
Vol 11 (11) ◽  
pp. 702-704 ◽  
Author(s):  
Scott E. Sherman ◽  
Ming Ming Wang ◽  
Bob Nguyen
Keyword(s):  
Smoking Cessation ◽  
Predictors Of Success ◽  
Cessation Clinic ◽  
Smoking Cessation Clinic

scholarly journals Evaluating level of adherence to nicotine replacement therapy and its impact on smoking cessation: a protocol for systematic review and meta-analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e039775 ◽  
Author(s):  
Amanual Getnet Mersha ◽  
Parivash Eftekhari ◽  
Michelle Bovill ◽  
Daniel Nigusse Tollosa ◽  
Gillian Sandra Gould
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Smoking Cessation ◽  
Replacement Therapy ◽  
Nicotine Replacement Therapy ◽  
Assessment Tool ◽  
Meta Analysis ◽  
Population Based ◽  
Reverse Causality ◽  
Nicotine Replacement

IntroductionNicotine replacement therapy (NRT) has proven effective for smoking cessation in clinical trials, however it was found less effective in population-based studies, potentially due to inconsistent or incorrect use of NRT. The aim of this paper is to describe a systematic review protocol to evaluate level of adherence to NRT; the discrepancy of adherence to NRT in clinical and population-based studies and degree of association between level of adherence and success of smoking cessation.Methods and analysisLiterature search will use five databases (Medline, Scopus, Embase, CINAHL and PsycINFO). Studies will be appraised for methodological quality using National Institutes of Health Quality Assessment Tool. To reduce heterogeneity, we will analyse clinical trials and population-based studies separately; pooled analyses will be done among studies that used similar measurements. Heterogeneity of studies will be assessed by Higgins’ I2 statistical test. When studies are adequately homogeneous, results will be pooled using random-effects model with proportion and ORs with 95% CIs and p values for each outcome. We will explain sources of heterogeneity by subgroup analysis or sensitivity analysis. Funnel plots and Egger’s regression asymmetry test with p<0.05 will be used as a cut-off point to affirm presence of statistically significant publication bias. Statistical analyses will be carried out using Stata V.16 software. Only studies reporting a valid strategy to control for reverse causality will be included.DiscussionThis review will provide evidence to support the importance of adherence on rate of smoking cessation and level of adherence to NRT. The findings will be used to inform smoking cessation interventions, researchers and policymakers.Ethics and disseminationAs a systematic literature review, this protocol does not require ethics approval. Research outcomes will be presented at relevant conferences and findings will be published in a relevant peer-reviewed journal.PROSPERO registration numberCRD42020176749.

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