scholarly journals Omega-3 polyunsaturated fatty acid oral supplements for improving peripheral nerve health: a systematic review and meta-analysis

2019 ◽  
Vol 78 (4) ◽  
pp. 323-341 ◽  
Author(s):  
Alexis Ceecee Zhang ◽  
Manikkuwadura Eranda Harshan De Silva ◽  
Richard J MacIsaac ◽  
Leslie Roberts ◽  
Jordan Kamel ◽  
...  
Keyword(s):  
Systematic Review ◽  
Peripheral Nerve ◽  
Psychological Health ◽  
Sensory Nerve ◽  
Nerve Damage ◽  
Sensory Loss ◽  
Omega 3 ◽  
Peripheral Nerve Damage ◽  
Nerve Structure ◽  
Oral Supplements

Abstract Context Peripheral nerve damage can occur in a variety of systemic conditions and can have a profound impact on functional and psychological health. Currently, therapeutic interventions for peripheral nerve damage are limited. Objective The aim of this systematic review, conducted in accordance with the Cochrane Collaboration’s handbook and reported according to the PRISMA checklist, was to evaluate the efficacy and safety of omega-3 oral supplements for improving peripheral nerve structure and function. Data Sources PubMed, Embase, and Cochrane databases, along with clinical trial registries, were searched from inception to February 2019. Evidence was identified, critically appraised, and synthesized, and the certainty of evidence was appraised using the Grading of Recommendations Assessment, Development and Evaluation approach. Study Selection Randomized controlled trials assessing the effects of omega-3 oral supplementation on outcomes of peripheral nerve structure, peripheral nerve function, or both were eligible for inclusion. Titles and abstracts of identified articles were independently assessed for potential eligibility by 2 review authors. For studies judged as eligible or potentially eligible, full text articles were retrieved and independently assessed by 2 review authors to determine eligibility; disagreements were resolved by consensus. Data Extraction Fifteen trials were included. Two clinically similar studies that investigated the effect of omega-3 supplementation in individuals receiving chemotherapy were meta-analyzed. Pooled data showed a reduced incidence of peripheral neuropathy (RR = 0.58; 95%CI, 0.43–0.77) and a preservation of sensory nerve action potential amplitudes with omega-3 supplementation compared with placebo (MD = 4.19 µV; 95%CI; 2.19–6.19). Conclusion This review finds, with low certainty, that omega-3 supplementation attenuates sensory loss and reduces the incidence of neuropathy secondary to oxaliplatin and paclitaxel treatment relative to placebo. There is currently limited evidence to ascertain whether omega-3 supplementation is beneficial in other systemic conditions characterized by peripheral nerve damage. Systematic Review Registration PROSPERO registration number CRD 42018086297

scholarly journals Fast-spiking GABA circuit dynamics in the auditory cortex predict recovery of sensory processing following peripheral nerve damage

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Jennifer Resnik ◽  
Daniel B Polley
Keyword(s):  
Peripheral Nerve ◽  
Auditory Cortex ◽  
Sensory Processing ◽  
Cortical Neurons ◽  
Sensory Nerve ◽  
Intracortical Inhibition ◽  
Nerve Fibers ◽  
Nerve Damage ◽  
Inhibitory Neurons ◽  
Sound Processing

Cortical neurons remap their receptive fields and rescale sensitivity to spared peripheral inputs following sensory nerve damage. To address how these plasticity processes are coordinated over the course of functional recovery, we tracked receptive field reorganization, spontaneous activity, and response gain from individual principal neurons in the adult mouse auditory cortex over a 50-day period surrounding either moderate or massive auditory nerve damage. We related the day-by-day recovery of sound processing to dynamic changes in the strength of intracortical inhibition from parvalbumin-expressing (PV) inhibitory neurons. Whereas the status of brainstem-evoked potentials did not predict the recovery of sensory responses to surviving nerve fibers, homeostatic adjustments in PV-mediated inhibition during the first days following injury could predict the eventual recovery of cortical sound processing weeks later. These findings underscore the potential importance of self-regulated inhibitory dynamics for the restoration of sensory processing in excitatory neurons following peripheral nerve injuries.

Focal peripheral neuropathy

2011 ◽  
Author(s):  
Michael Donaghy
Keyword(s):  
Peripheral Nerve ◽  
Immunosuppressive Treatment ◽  
Conduction Block ◽  
Multifocal Motor Neuropathy ◽  
Nerve Damage ◽  
High Dose ◽  
Motor Neuropathy ◽  
Peripheral Nerve Damage ◽  
Entrapment Neuropathies ◽  
Focal Neuropathy

Some causes of focal peripheral nerve damage are self-evident, such as involvement at sites of trauma, tissue necrosis, infiltration by tumour, or damage by radiotherapy. Focal compressive and entrapment neuropathies are particularly valuable to identify in civilian practice, since recovery may follow relief of the compression. Leprosy is a common global cause of focal neuropathy, which involves prominent loss of pain sensation with secondary acromutilation, and requires early antibiotic treatment. Mononeuritis multiplex due to vasculitis requires prompt diagnosis and immunosuppressive treatment to limit the severity and extent of peripheral nerve damage. Various other medical conditions, both inherited and acquired, can present with focal neuropathy rather than polyneuropathy, the most common of which are diabetes mellitus and hereditary liability to pressure palsies. A purely motor focal presentation should raise the question of multifocal motor neuropathy with conduction block, which usually responds well to high-dose intravenous immunoglobulin infusions.

scholarly journals Association of Serum Cholesterol Levels With Peripheral Nerve Damage in Patients With Type 2 Diabetes

2019 ◽  
Vol 2 (5) ◽  
pp. e194798 ◽  
Author(s):  
Johann M. E. Jende ◽  
Jan B. Groener ◽  
Christian Rother ◽  
Zoltan Kender ◽  
Artur Hahn ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Nerve ◽  
Serum Cholesterol ◽  
Nerve Damage ◽  
Peripheral Nerve Damage ◽  
Cholesterol Levels

scholarly journals Ipsilateral cortical fMRI responses after peripheral nerve damage in rats reflect increased interneuron activity

2009 ◽  
Vol 106 (33) ◽  
pp. 14114-14119 ◽  
Author(s):  
G. Pelled ◽  
D. A. Bergstrom ◽  
P. L. Tierney ◽  
R. S. Conroy ◽  
K.-H. Chuang ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Damage ◽  
Peripheral Nerve Damage ◽  
Interneuron Activity

scholarly journals Photobiostimulation reverses allodynia and peripheral nerve damage in streptozotocin-induced type 1 diabetes

2017 ◽  
Vol 32 (3) ◽  
pp. 495-501 ◽  
Author(s):  
Igor Rafael Correia Rocha ◽  
Adriano Polican Ciena ◽  
Alyne Santana Rosa ◽  
Daniel Oliveira Martins ◽  
Marucia Chacur
Keyword(s):  
Type 1 Diabetes ◽  
Peripheral Nerve ◽  
Nerve Damage ◽  
Peripheral Nerve Damage

Sulodexide prevents peripheral nerve damage in streptozotocin induced diabetic rats

2012 ◽  
Vol 674 (2-3) ◽  
pp. 217-226 ◽  
Author(s):  
Heung Yong Jin ◽  
Kyung Ae Lee ◽  
Sun Kyung Song ◽  
Wei Jing Liu ◽  
Ji Hae Choi ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Diabetic Rats ◽  
Nerve Damage ◽  
Peripheral Nerve Damage

scholarly journals A Study of Tapping by the Unaffected Finger of Patients Presenting with Central and Peripheral Nerve Damage

2015 ◽  
Vol 9 ◽  
Author(s):  
Lingli Zhang ◽  
Xiuying Han ◽  
Peihong Li ◽  
Yang Liu ◽  
Yulian Zhu ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Damage ◽  
Peripheral Nerve Damage

Peripheral Nerve Damage by Cold

1967 ◽  
Vol 16 (1) ◽  
pp. 103-109 ◽  
Author(s):  
H. SCHAUMBURG ◽  
R. BYCK ◽  
R. HERMAN ◽  
C. ROSENGART
Keyword(s):  
Peripheral Nerve ◽  
Nerve Damage ◽  
Peripheral Nerve Damage
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