The History of Solid Organ Transplantation

2021 ◽  
pp. 22-52
Author(s):  
Lainie Friedman ◽  
J. Richard Thistlethwaite, Jr

This chapter provides a brief history of solid organ transplantation. Although the focus is on the living donor, the history of living donor solid organ transplantation is intertwined with the history of deceased donor solid organ transplantation. This is particularly true in the early years of solid organ transplantation when the earliest success for some solid organ transplants began with living donors, e.g. kidney, and began with deceased donors for other solid organ transplants, e.g. liver. The history of each solid organ in which living donors have supplied grafts (kidney, liver, lung, pancreas, intestines, and uterus) is described even though some are rarely if ever performed today, e.g. lung, intestine, pancreas. We also discuss the living domino donor—a candidate-recipient (most commonly the recipient of a deceased donor liver or heart) whose own organ is not discarded but is transplanted into another person.

2019 ◽  
Vol 130 (3) ◽  
Author(s):  
Zaid Al‐Qurayshi ◽  
Jarrett Walsh ◽  
Scott Owen ◽  
Gregory Randolph ◽  
Emad Kandil

2013 ◽  
Vol 95 (10) ◽  
pp. 1183-1186 ◽  
Author(s):  
Colleen M. Krajewski ◽  
Duvuru Geetha ◽  
Veronica Gomez-Lobo

Spine ◽  
2014 ◽  
Vol 39 (19) ◽  
pp. E1154-E1158 ◽  
Author(s):  
Jonathan Falakassa ◽  
Brandon P. Hirsch ◽  
Robert P. Norton ◽  
Matthew Mendez-Zfass ◽  
Frank J. Eismont

Author(s):  
Marie Wright ◽  
Mark Chilvers ◽  
Tom Blydt-Hansen

Background Solid organ transplantation (SOT) has become commonly used in children and is associated with excellent survival rates into adulthood. Data regarding long-term respiratory outcomes following pediatric transplantation are lacking. We aimed to describe the prevalence and nature of respiratory pathology following pediatric heart, kidney, and liver transplant, and identify potential risk factors for respiratory complications. Methods Retrospective review involving all children under active follow-up at the provincial transplant service in British Columbia, Canada, following SOT. Results Of 118 children, 33% experienced respiratory complications, increasing to 54% in heart transplant recipients. Chronic or recurrent cough with persistent chest x-ray changes was the most common clinical picture, and most infections were with non-opportunistic organisms typically found in otherwise healthy children. A history of respiratory illness prior to transplant was significantly associated with risk of post-transplant respiratory complications. 8% were diagnosed with bronchiectasis, which was more common in recipients of heart and kidney transplant. Bronchiectasis was associated with recurrent hospital admissions with lower respiratory tract infections, treatment of acute rejection episodes, and treatment with sirolimus. Interpretation Respiratory morbidity is common after pediatric SOT, and bronchiectasis rates were disproportionately high in this patient group. We hypothesise that this relates to recurrent infections resulting from iatrogenic immunosuppression. Direct pulmonary toxicity from immunosuppression drugs may also be contributory. A high index of suspicion for respiratory complications is needed following childhood SOT, particularly in those with a history of respiratory disease prior to transplant, experiencing recurrent or severe respiratory tract infections, or exposed to intensified immunosuppression.


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