It is extremely dangerous to resist extractive megaprojects in Latin America. The intensive accumulation of natural resources for export on global markets has long characterized Latin America, but the boom in exports of raw commodities since 2000 has accentuated a violent history of dispossession. As of 2020, Latin America represents 60% of nature defenders killed in the world. Governments license natural resources at unprecedented rates, pushing land- and water-grabbing to new levels. Resistance against mining, oil, hydroelectric, and agribusiness projects is framed as antidevelopment and repressed with brutal violence. Governments are expanding the extractive frontier fast, promoting megaprojects in the name of national development or to fund social policies, a so-called redistributive neo-extractivism. This extractive consensus has increased social conflict across the region; but it has also inspired new forms of resistance. Resistance, which is mostly Indigenous and largely female, is a political struggle against extractive industries that represent ongoing forms of colonial dispossession. Resistance against extractivism focuses on the defense of nature as much as on rights to self-determination, a central element to shape a postextractive world. Ecuador is a case in point. The country recognizes international rights to prior consultation and established the first rights of nature framework in the world, yet it criminalizes nature defenders as it continues to expand the extractive frontier. The emerging rights of nature framework, like mining bans, are alternatives to extractivism that offer insights into experiences of resistance in the highlands of Ecuador. The Rio Blanco mine, an iconic megaproject financed by China, was suspended in 2018 thanks to a solid network of resistance that secured a broad mobilization of rural communities and urban youth, lawyers and academics, blending street protest with legal action. The Rio Blanco case shows the complementarity of various strategies, the potential of courts as allies, and the powerful coordination between social movements and government to contest structural dispossession.