Enzymatic Formation of a Nonreducing L-Ascorbic Acid a-Glucoside: Purification and Properties of a-Glucosidases Catalyzing Site-Specific Transglucosylation from Rat Small Intestine

1990 ◽  
Vol 107 (2) ◽  
pp. 222-227 ◽  
Author(s):  
Norio Muto ◽  
Tomoe Nakamura ◽  
Itaru Yamamoto
Parasitology ◽  
1944 ◽  
Vol 36 (1-2) ◽  
pp. 98-109 ◽  
Author(s):  
W. P. Rogers

1. A method for examining conditions governing anthelmintic activity in the small intestine is described. Nippostrongylus muris in the rat was the test organism and hexylresorcinol and C2C14 were the drugs examined.2. The efficiency of hexylresorcinol was reduced by 50% in 1% sodium tauroglycocholate which reached a concentration of 1·3% in the rat small intestine. The adsorption of this drug on mucin reduced its concentration in intestinal fluids and prevented penetration to parasites under mucus. These inhibiting factors account for the inactivity of hexylresorcinol in the rat.3. Tetrachlorethylene, which stimulated N. muris to leave mucus and enter fluids in the intestinal lumen, was not inhibited by bile salt and was found to act rapidly in the rat.4. Sodium laurate activated hexylresorcinol more efficiently than sodium oleate at pH. 6·5. Both soaps showed intrinsic anthelmintic properties.5. The results obtained in examining the rate of movement of fluids down the intestine and the effects of detergents, bile salts, mucin and ascorbic acid on drug activity are discussed.


1975 ◽  
Vol 403 (1) ◽  
pp. 139-146 ◽  
Author(s):  
Koji Sasajima ◽  
Takashi Kawachi ◽  
Shigeaki Sato ◽  
Takaishi Sugimura

2003 ◽  
Vol 306 (1) ◽  
pp. 310-316 ◽  
Author(s):  
Shigeki Tamura ◽  
Yuji Tokunaga ◽  
Rinta Ibuki ◽  
Gordon L. Amidon ◽  
Hitoshi Sezaki ◽  
...  

1997 ◽  
Vol 10 (2) ◽  
pp. 89-95 ◽  
Author(s):  
Michio Nakamura ◽  
Michitaka Ozaki ◽  
Shohei Fuchinoue ◽  
Satoshi Teraoka ◽  
Kazuo Ota

2001 ◽  
Vol 120 (5) ◽  
pp. A183-A183
Author(s):  
H KOBAYASHI ◽  
H NAGATA ◽  
S MIURA ◽  
T AZUMA ◽  
H SUZUKI ◽  
...  

2008 ◽  
Vol 29 (S 1) ◽  
Author(s):  
K Nieber ◽  
S Michael ◽  
K Grötzinger ◽  
JW Rauwald ◽  
O Kelber

Diabetes ◽  
1993 ◽  
Vol 42 (8) ◽  
pp. 1126-1132 ◽  
Author(s):  
K. L. Madsen ◽  
V. M. Porter ◽  
R. N. Fedorak

Sign in / Sign up

Export Citation Format

Share Document