scholarly journals The Eukaryote Genome in Development and Evolution by B. John and G. Miklos

2010 ◽  
Vol 65 (1) ◽  
pp. 65-83 ◽  
Author(s):  
Bernadette Péley

A tanulmány amellett érvel, hogy az adaptív mechanizmusoknak és diszfunkcióiknak a finom elemzése jelentősen hozzájárul a fejlődés és a betegségek jobb megértéséhez, és a betegségek osztályozásának és a terápiáknak új útját nyithatja meg. Az evolúciós megközelítés a pszichoterápiába nem új elméletet vagy terápiás megközelítést kíván bevezetni, hanem az emberi természet törvényszerűségei mentén új megértési stratégiákat javasol. A patológiás szerveződést alapvetően az adaptivitás dimenziójában gondolja el. Ez kikényszeríti a fejlődési történet és a multikauzalitás szem előtt tartását. Hosszú távon ez a tüneti kategorizáción alapuló diagnosztika újragondolását is jelenti.


Author(s):  
Anthony Moung Yin Chan ◽  
Paul Lo ◽  
Kong Ng

Our study covered the development and evolution of the management accounting system of a subsidiary company in a group. Our study was a longitudinal one starting from the incorporation of the company. We divided this period into five stages according to the major events happened, namely the formation of the company, the invoicing crisis, the conflict with parent company, the conflict with fellow subsidiaries, and the influence of the chief executive. In our analysis we applied the three dimensions of structure in the theory of structuration (i.e., signification, legitimation and domination). The structuration theory explained the emergence of certain phenomena and events that were not explained by traditional accounting theories. Many events in our study validated the core ideas of the structuration theory which composes of the concepts of structure, system and duality of structure. The phenomena suggested that structure was both the medium and outcome of the conduct it recursively organized. Other features of the theory, such as the dialectic of control and system contradiction, were also applicable


2001 ◽  
Vol 71 (3) ◽  
pp. 116-125
Author(s):  
Norina Basa ◽  
Daniela Lazar ◽  
Remus Cornea ◽  
Sorina Taban ◽  
Melania Ardelean ◽  
...  

Alteration of β-catenin expression is involved in the development and evolution of hepatocellular carcinoma (HCC); β-catenin is able to influence tumor cell proliferation. We analyzed the immunohistochemical (IHC) expression of β-catenin on a group of 32 patients diagnosed with HCC using the anti-β-catenin monoclonal antibody (clone E247). We correlated the expression of β-catenin with the proliferation index of Ki-67 (PI Ki-67), the mitotic index (MI) and other clinical and pathological features. We observed an altered β-catenin expression in 58.38% of all HCC cases. This expression was insignificantly correlated with tumor size (]5 cm) (p = 0.683), histological grade G1-G2 (p = 0.307), vascular invasion (p = 0.299) and advanced pT stage (p = 0.453); we obtained a significantly higher MI in HCC with altered β-catenin expression (p = 0.018), as compared to HCC without overexpression (1.66 � 1.37) (p = 0.038) and a PI Ki-67 of 22.49 � 20.1 and 28.24 � 18.2, respectively in tumors with altered β-catenin expression with insignificant differences compared to HCC without overexpression (25.95 � 15.2) (p = 0.682 and p = 0.731, respectively). According to the results we obtained, aberrant β-catenin expression in HCC was correlated with a high mitotic index, therefore playing an important role in tumor progression by stimulating tumor cell proliferation; non-nuclear β-catenin overexpression can have a pathological significance in HCC, especially in cases of HCC associated with hepatitis B virus (HBV) infection.


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