Effect of Gibberellic Acid and Metabolic Inhibitors of DNA and RNA Synthesis on Hypocotyl Elongation and Cell Wall Loosening in Dark-Grown Lettuce Seedlings

1981 ◽  
Keyword(s):  
Cell Wall ◽  
Gibberellic Acid ◽  
Rna Synthesis ◽  
Hypocotyl Elongation ◽  
Metabolic Inhibitors ◽  
Cell Wall Loosening ◽  
Dna And Rna ◽  
Dna And Rna Synthesis ◽  
Wall Loosening

Mechanism of Acid Tolerance by a Yeast Isolated from Spoiled Ketchup

1988 ◽  
Vol 51 (6) ◽  
pp. 489-490 ◽  
Author(s):  
KENT M. SORRELLS ◽  
BARBARA LEONARD
Keyword(s):  
Acetic Acid ◽  
Cell Walls ◽  
Rna Synthesis ◽  
Acid Tolerance ◽  
Metabolic Inhibitors ◽  
Limited Extent ◽  
Acid Growth ◽  
Potato Dextrose Broth ◽  
Dna And Rna ◽  
Dna And Rna Synthesis

A yeast, isolated from spoiled ketchup, grew at a relatively high (0.8%) concentration of acetic acid. The addition of specific metabolic inhibitors in sub-lethal concentrations to acidified Potato Dextrose broth was used to study the mechanism of resistance of the yeast to acid. Growth in non-acidified medium was not affected by most inhibitors and to a limited extent by DNA and RNA inhibitors. Growth in the acidified medium was affected only slightly by the presence of inhibitors of protein (mitochondrial), DNA and RNA synthesis. 2,4-Dinitrophenol and D-cycloserine were the only inhibitors that inhibited growth in acidified media, suggesting acid tolerance involves an energy requiring system as well as cell walls, possibly transport.

scholarly journals DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-indole Antibiotics

2016 ◽  
pp. AAC.00309-16 ◽  
Author(s):  
Timothy J. Opperman ◽  
Steven M. Kwasny ◽  
Jessica Bo Li ◽  
Mark A. Lewis ◽  
Daniel Aiello ◽  
...  
Keyword(s):  
Cell Wall ◽  
Rna Synthesis ◽  
Antibacterial Properties ◽  
Wall Stress ◽  
Secondary Effects ◽  
E Coli ◽  
Dna Targeting ◽  
Cell Wall Stress ◽  
Dna And Rna ◽  
Dna And Rna Synthesis

We previously reported the synthesis and biological activity of a series of cationic bis-indoles with potent, broad spectrum antibacterial properties. Here, we describe mechanism of action studies to test the hypothesis that these compounds bind to DNA and that this target plays an important role in their antibacterial outcome. Results reported here indicate that the bis-indoles bind selectively to DNA at A/T rich sites, which is correlated with the inhibition of DNA and RNA synthesis in representative Gram-positive (S. aureus) and Gram–negative (E. coli) organisms. Further, exposure ofEscherichia coliandStaphylococcus aureusto representative bis-indoles resulted in induction of the DNA damage inducible SOS response. In addition, the bis-indoles were found to be potent inhibitors of cell wall biosynthesis, however, they do not induce the cell wall stress stimulon inS. aureus, suggesting that this pathway is inhibited by an indirect mechanism. In light of these findings, the most likely basis for the observed activities of these compounds is their ability to bind to the minor groove of DNA, resulting in the inhibition of DNA and RNA synthesis and other secondary effects.

The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited

1995 ◽  
Vol 20 (10) ◽  
pp. 431-434 ◽  
Author(s):  
Olga B. Chernova ◽  
Michail V. Chernov ◽  
Munna L. Agarwal ◽  
William R. Taylor ◽  
George R. Stark
Keyword(s):  
Rna Synthesis ◽  
Genomic Stability ◽  
Dna And Rna ◽  
Dna And Rna Synthesis

Studies on DNA and RNA synthesis in tsetse flies

1972 ◽  
Vol 66 (2) ◽  
pp. 329-330 ◽  
Author(s):  
T.A. Craig-Cameron ◽  
D.I. Southern ◽  
P.E. Pell
Keyword(s):  
Rna Synthesis ◽  
Tsetse Flies ◽  
Dna And Rna ◽  
Dna And Rna Synthesis
Sign in / Sign up

Export Citation Format

Share Document