scholarly journals Serum transferrin receptor assay in iron deficiency anaemia and anaemia of chronic disease in the elderly

QJM ◽  
1999 ◽  
Vol 92 (10) ◽  
pp. 587-594 ◽  
Author(s):  
E. Chua
Keyword(s):  
Chronic Disease ◽  
Iron Deficiency ◽  
Transferrin Receptor ◽  
Iron Deficiency Anaemia ◽  
The Elderly ◽  
Serum Transferrin ◽  
Deficiency Anaemia ◽  
Serum Transferrin Receptor ◽  
Anaemia Of Chronic Disease ◽  
Receptor Assay

The Ratio of Serum Transferrin Receptor and Serum Ferritin in the Diagnosis of Iron Deficiency Anaemia in Young Children

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3746-3746
Author(s):  
EunSil Park ◽  
In-Suk Kim ◽  
JiHyun Seo ◽  
JaeYoung Lim ◽  
ChanHoo Park ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Transferrin Receptor ◽  
Iron Deficiency Anaemia ◽  
Normal Group ◽  
Growth Spurt ◽  
Serum Transferrin ◽  
Deficiency Anaemia ◽  
Serum Transferrin Receptor ◽  
The Mean

Abstract The incidence of iron deficiency anaemia in 6∼24 month old infants due to increase in iron demand for growth spurt is reported ranged 10 to 40%. However this age group has a common acute illness such as urinary tract infection, pneumonia, and other viral infections. The aim of this study is to evaluate that iron parameter and acute phase reactant are useful parameters in differentiating anaemia by infection from anemia by iron deficiency and the mixed anaemia of these. Among 6–24 months of the infants who visited Gyeongsang Univeristy Hospital for 7 years from 2000 to 2006, 131 infants were enrolled. Hemoglobin(Hb), serum ferritin(SF), serum transferrin receptor(STfR), C reactive protein(CRP), interleukin-6(IL-6), prohepcidine were checked. The subgroup of anaemia of inflammation(AI) was defined as Hb <11 g/dL and SF >50 μg/L, the subgroup of iron deficiency anaemia(IDA) as Hb <11 g/dL and SF <12 μg/L and the normal group as Hb ≥11 and SF ≥12 μg/L. The mean STfR in the subgroup of AI, IDA and normal was 3.89(±2.64), 10.6(±4.95) and 3.96(±1.24), respectively. The mean STfR/Log SF of subgroup was 1.87(±1.55), 36.11(±71.5), 2.31(±0.97), respectively. The mean Log(STfR/SF) was statistically significant between 3 subgroup. All IDA group had Log(STfR/SF) >2.55 whereas in all subjects classified as AI it was <2.55, thus clearly separating two. The mean IL-6 of AI was significantly higher than IDA subgroup and the mean prohepcidine of AI was significantly lower than the normal group. Calculating Log(STfR/SF) is a useful criteria in classification of the iron status. Prohepcine has nothing to do with AI. Iron signal predominant over inflammatory signal in AI. The Mean(±SD) of STfR, STfR/LogSF, Log (TfR/SF), CRP, IL-6 and Prohepcidine in Subgroups. AI IDA Normal Same letters mean that are not significantly different (P <0.05) AI, anaemia of inflammation; IDA, iron deficiency anaemia Subgroup(%) 33(25) 29(22) 69(53) Hg(g/dL) <11 <11 ≥11 SF(μg/L) >50 <12 ≥12 STfR mean(±SD) 3.89(2.64)a 10.6(4.95) b 3.96(1.24) a STfR/LogSF mean (±SD) 1.87(1.55) a 36.11(71.5) b 2.31(0.97) a Log (TfR/SF) mean(±SD) 1.30(0.56) a 3.29(0.43) b 1.76(0.43) c CRP mean(±SD) 28(39.2) a 7.6(9.6) b 17(28.0) a IL-6 mean(±SD) 6.1(10.5) a 2.0(6.3) b 4.78(11.3) c Prohepcidine mean(±SD) 204(70.5) a 234(144) a 301(120.6) b Fig.1. Log(TfR/SF) in the subgroup. AI, anaemia of inflammation; IDA, Iron deficiency anaemia. Dotted lines indicate the cut-off value at Log(TfR/SF)=2.55 Fig.1. Log(TfR/SF) in the subgroup. AI, anaemia of inflammation; IDA, Iron deficiency anaemia. Dotted lines indicate the cut-off value at Log(TfR/SF)=2.55

scholarly journals The Value of Soluble Transferrin Receptor and Soluble Transferrin Receptor-ferritin Index in Discriminating Iron Deficiency Anaemia from Anaemia of Chronic Disease in Patients With Rheumatoid Arthritis

2019 ◽  
Vol 13 (1) ◽  
pp. 9-14
Author(s):  
Haithem A. Al-Rubaie ◽  
Israa M. Al-Bayaa ◽  
Yassmin A. Al-Amiri
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Disease ◽  
Iron Deficiency ◽  
Transferrin Receptor ◽  
Iron Deficiency Anaemia ◽  
Soluble Form ◽  
Soluble Transferrin Receptor ◽  
Deficiency Anaemia ◽  
Inflammatory Status ◽  
Anaemia Of Chronic Disease

Background:Anaemia is a common extra-articular manifestation of rheumatoid arthritis (RA) where anaemia of chronic disease (ACD) and iron deficiency anaemia (IDA) are the two most frequent types. The distinction between these two types of anaemia has always been challenging requiring sophisticated techniques. Serum transferrin receptor (sTfR) a truncated soluble form of the transferrin receptor is one of the parameters that is influenced by the Iron content and supply to the erythrons and is not affected by inflammatory status and therefore the use of the sTfR/log ferritin (sTfR-F) index can be a reliable indicator of functional iron deficiency.Aim of the study:This study aims to evaluate the usefulness of sTfR and sTfR-F index in discriminating the most common types of anaemia in patients with RA.Patients and methods:The study included 50 patients with RA and 30 healthy subjects as a control group. Complete blood picture, C-reactive protein, serum Iron, unsaturated iron binding capacity, sTfR and serum ferritin were tested.Results and Conclusion:anaemia was present in 34/50 patients; 19 patients had ACD, 9 had ACD/IDA and only 6 patients had IDA. Both the sTfR and the sTfR-F index showed a significant difference between anaemia groups (P values = 0.037 and 0.001, respectively). sTfR-F index has shown to be a very useful parameter that can discriminate efficiently between IDA and ACD and between ACD and ACD/IDA in patients with RA.

scholarly journals Suitability of soluble transferrin receptor for the clinical diagnosis of different types of anaemia in children

2002 ◽  
Vol 8 (2-3) ◽  
pp. 298-307
Author(s):  
L. Ragab ◽  
H. A. Ibrahim ◽  
A. S. Eid ◽  
T. Kotb ◽  
M. F. Konsowa
Keyword(s):  
Chronic Disease ◽  
Iron Deficiency ◽  
Transferrin Receptor ◽  
Iron Deficiency Anaemia ◽  
Iron Status ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Egyptian Children ◽  
Different Types ◽  
Patient Groups

We evaluated the ability of serum transferrin receptor [sTFR] to identify different types of anaemia in children. Thus 150 Egyptian children suffering from anaemia [iron deficiency anaemia, anaemia of chronic disease and beta-thalassaemia] were enrolled, together with 50 controls. There was a significant increase in the mean levels of sTFR in the groups with iron deficiency anaemia and thalassaemia, and a significant decrease in mean sTFR levels in the group with anaemia of chronic disease. Serum ferritin levels were significantly higher in all patient groups except the group with iron deficiency anaemia. There were also significant correlations between the sTFR and sTFR/log ferritin ratio [sTFR-F index] and different indices of iron status and of erythropoiesis. The sTFR-F index could be used as a diagnostic or screening tool for iron deficiency anaemia, anaemia of chronic disease and thalassaemia.

scholarly journals Ferritin and iron studies in anaemia and chronic disease

2016 ◽  
Vol 54 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Ying Y Peng ◽  
James Uprichard
Keyword(s):  
Chronic Disease ◽  
Iron Deficiency ◽  
Iron Overload ◽  
Iron Deficiency Anaemia ◽  
Iron Homeostasis ◽  
Red Cells ◽  
Pivotal Role ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Common Causes

Anaemia is a condition in which the number of red cells necessary to meet the body's physiological requirements is insufficient. Iron deficiency anaemia and the anaemia of chronic disease are the two most common causes of anaemia worldwide;1 iron homeostasis plays a pivotal role in the pathogenesis of both diseases. An understanding of how iron studies can be used to distinguish between these diseases is therefore essential not only for diagnosis but also in guiding management. This review will primarily focus on iron deficiency anaemia and anaemia of chronic disease; however, iron overload in anaemia will also be briefly discussed.

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