Study of Urinary Calprotectin Levels in Type 2 Diabetics with Peripheral Arterial Disease

Abstract Objective The aim of the present study is to investigate the association of urinary calprotectin levels with lower extremities peripheral arterial disease (LEPAD) in patients with type 2 diabetes mellitus (T2DM). Background calprotectin is formed by two different calcium- binding proteins; it constitutes about 40% of neutrophils all cytosolic proteins. Calprotectin or its components (S100A8/S100A9) consider as a potential therapeutic target in inflammatory conditions including diabetes mellitus. The ankle-brachial index of less than 0.9 was applied for LEPAD diagnosis. Method we recruited 60 patients with T2DM; half of them had LEPAD and a healthy control group consists of 30 participants. Urinary Calprotectin and high sensitivity CRP (hsCRP) were measured by enzyme-linked immunoassay kit. Results Urinary calprotectin level was statistically significant higher among the three participating groups (p value <0.001), however, in post-hoc analysis there was no difference between patients with type 2 diabetes mellitus with or without LEPAD (p value =0.993). However, urinary calprotectin was weakly associated with LEPAD severity (p value = 0.175, p value = 0.06 respectively).There was a statistically significant positive correlation between urinary calprotectin level and hsCRP (r = 0.65, p value 0.001). Conclusion Urinary calprotectin cannot be used as a biomarker for LEPAD in T2DM.

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The relation of anatomical distribution of symptomatic peripheral arterial disease (PAD) with HbA1c level in patients with type 2 diabetes mellitus

Therapeutic Advances in Endocrinology and Metabolism ◽

10.1177/20420188211000504 ◽

2021 ◽

Vol 12 ◽

pp. 204201882110005

Author(s):

Nawaf J. Shatnawi ◽

Nabil A. Al-Zoubi ◽

Hassan M. Hawamdeh ◽

Yousef S. Khader ◽

Mowafeq Heis ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Peripheral Arterial Disease ◽

Hba1c Level ◽

Arterial Disease ◽

Anatomical Distribution ◽

The Mean ◽

Peripheral Arterial

Aims: Increased level of glycated hemoglobin (HbA1c) is associated with an increased prevalence of peripheral arterial disease (PAD). This study aimed to assess the relationship between the anatomical distribution of symptomatic PAD lesions in patients with type 2 diabetes and HbA1c levels at the time of PAD diagnosis. Patients and methods: A retrospective study was conducted at King Abdullah University Hospital during the period August 2011 to December 2015. Consecutive patients with type 2 diabetes presented with symptomatic PAD confirmed by computed tomography-angiography (CTA) were included in this study. CTA images were reviewed. Relevant information including demographic data, PAD symptoms, comorbidities, HbA1c level, lipid profile, C-reactive protein and the mean platelets volume were retrieved from medical records. Results: A total of 332 patients with type 2 diabetes (255 males and 77 females) were included in this study. The mean HbA1c at the time of PAD diagnosis was 8.68% (±2.06%). The prevalence of hemodynamic relevant atherosclerotic lesions of the superficial femoral artery, popliteal artery, leg vessels, femoro-popliteal, and crural segments was significantly higher in patients with HbA1c >7.5% compared with patients with HbA1c ⩽7.5%. Conclusion: The anatomical distribution of symptomatic PAD in patients with type 2 diabetes mellitus differed significantly according to HbA1c level at the time of PAD diagnosis.

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