Evaluation of the efficacy of homologous autoinoculation therapy in treatment of multiple recalcitrant warts
Abstract Background Warts are infections caused by human papillomavirus (HPV). There are new trends towards the use of immunotherapy in treatment of warts. Homologous autoinoculation is a minimally invasive procedure, which treats warts by stimulating a specific immune response against HPV Objective To evaluate the efficacy of autoinoculation therapy in treatment of multiple recalcitrant warts. Methods Under local anesthesia and aseptic condition, inoculum was collected by paring a wart by scalpel and by pressing it between two sterile glass slides. After making a subcutaneous Pocket in non-dominant forearm, the inoculum was introduced in the subcutaneous pocket with forceps and dressed. Follow up for 1,2,12 and 16 weeks was done. Results Fourty patients were included. At 12 weeks of therapy 42.5% showed complete clearance, 27.5% showed moderate clearance, 15% showed mild clearance and 12.5% showed treatment failure. No significant complication was documented after 1 and 2 weeks of follow up except in 3 patients in form of mild inflammation and mild pain. There was no recurrence at16 weeks follow up session. Conclusion Autoinoculation is simple and effective method in treatment of different types of warts including genital wart. It also prevents recurrence.