scholarly journals Adequacy of thyroid hormone replacement in a general population

QJM ◽  
2010 ◽  
Vol 104 (5) ◽  
pp. 395-401 ◽  
Author(s):  
O. E. Okosieme ◽  
G. Belludi ◽  
K. Spittle ◽  
R. Kadiyala ◽  
J. Richards
2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Pratik Patel ◽  
Mikhael Bekkerman ◽  
Cristina Varallo-Rodriguez ◽  
Rajendra Rampersaud

Hypothyroidism is a prevalent condition in the general population that is treatable with appropriately dosed thyroid hormone replacement medication. Infrequently, patients will present with myxedema coma, characterized by hypothermia, hypotension, bradycardia, and altered mental status in the setting of severe hypothyroidism. Myxedema coma has also been known to manifest in a number of unusual and dangerous forms. Here, we present the case of a woman we diagnosed with an uncharacteristic expression of myxedema coma and nonconvulsive seizure complicated by a right middle cerebral artery infarct.


1980 ◽  
Vol 95 (4) ◽  
pp. 472-478 ◽  
Author(s):  
A. Eugene Pekary ◽  
Jerome M. Hershman ◽  
Clark T. Sawin

Abstract. Basal serum TSH and the peak TSH response to a 500 μg TRH bolus were measured in 57 euthyroid and in 29 hypothyroid subjects either receiving graded thyroid hormone replacement or acutely removed from full replacement therapy. Serum TSH, total T4 and T3 were determined by sensitive radioimmunoassay methods. The peak versus basal TSH data for hypothyroid patients were linear within individuals. The regression slope of the peak versus basal TSH data for all hypothyroid subjects did not differ significantly from the corresponding slope for all euthyroid subjects. Basal and peak TSH versus T3 and T4 data for hypothyroid patients were also linear within each individual. Moreover, the regression of the basal TSH values averaged over the non-replacement to full replacement state against the TSH versus T3 slope had a significant negative correlation. This trend leads to an array of regression lines which average to the familiar hyperbolic relationship between thyrotrophin and thyroid hormone levels in man.


Prescriber ◽  
2018 ◽  
Vol 29 (12) ◽  
pp. 30-33
Author(s):  
Anh Tran ◽  
Steve Hyer ◽  
Gabriella Bathgate ◽  
Onyebuchi Okosieme

2018 ◽  
Vol 8 (1) ◽  
pp. 24-28
Author(s):  
Sukriti Kumar ◽  
Sumit Rungta ◽  
Manish Gutch ◽  
Annesh Bhattacharya ◽  
Syed Mohd Razi ◽  
...  

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