Comment on: Beneficial effect of Mediterranean diet on disease activity and cardiovascular risk in systemic lupus erythematosus patients: a cross-sectional study

Rheumatology ◽  
2021 ◽  
Author(s):  
Yusuke Matsuo ◽  
Toshimasa Shimizu ◽  
Yoshie Gon ◽  
Motohiko Sato ◽  
Sho Matsushita ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cardiovascular Risk ◽  
Beneficial Effect ◽  
Disease Activity ◽  
Mediterranean Diet ◽  
Lupus Erythematosus ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Systemic Lupus ◽  
Cross Sectional

scholarly journals Correlation Between Cognitive Function with Disease Activity of Systemic Lupus Erythematosus Patients in Dr. Hasan Sadikin Hospital Bandung: An Analytical Cross-Sectional Study

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Aep Saepudin ◽  
Paulus Anam Ong ◽  
Syarief Hidayat ◽  
Andri Reza Rahmadi ◽  
Laniyati Hamijoyo
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Function ◽  
Disease Activity ◽  
Cognitive Dysfunction ◽  
Lupus Erythematosus ◽  
Cross Sectional Study ◽  
Median Score ◽  
Sectional Study ◽  
Systemic Lupus ◽  
Cross Sectional

Background: Cognitive dysfunction was found in 55-80% Neuropsychiatry Systemic Lupus Erythematosus (NPSLE) patients. Serious concern from clinicans was needed as its impact to patient’s quality of life. Disease activity is expected to be affecting patient’s cognitive function. Previous studies regarding correlation between disease activity and cognitive dysfunction showed various results. This study aimed to evaluate the correlation between disease activity and cognitive function in SLE patients.Methods: This study is an analytical cross-sectional study. Subjects were SLE patients at the rheumatology clinic of Dr. Hasan Sadikin Hospital Bandung during June-August 2017. Subject’s evaluations included disease activity assessment using SLE disease activity index-2K (SLEDAI-2K) and cognitive function assessment using MoCA-Ina test. Data were analyzed by using Spearman Rank correlation test. Results: Mean age of the subjects was 31 ± 8 years old, most of them were senior high school graduates (65.8 %) and median length of study was 12 years. Subject’s median duration of illness was 44 months. Their MoCA-Ina median score was 25, while SLEDAI-2K median score was 6. Cognitive dysfunctions were found in more than half of subjects (52.63%), which memory domain (78.95%) was most frequently impaired. Most of subjects were patients with active SLE (63.2%). Correlation test showed there was no correlation between SLEDAI-2K score and MoCA-Ina score (rs=0.023, p=0.445).Conclusion: There was no correlation between disease activity (SLEDAI-2K score) and cognitive function (MoCA-Ina score). Keywords: Cognitive dysfunction, MoCA-Ina, Systemic lupus erythematosus, SLEDAI-2K

scholarly journals Therapeutic adherence in patients with systemic lupus erythematosus: a cross-sectional study

2018 ◽  
Vol 56 (2) ◽  
pp. 109-115 ◽  
Author(s):  
Lucia Mazur-Nicorici ◽  
Victoria Sadovici-Bobeica ◽  
Maria Garabajiu ◽  
Minodora Mazur
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Adherence To Treatment ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Low Disease Activity ◽  
High Adherence

Abstract Introduction. The aim of the research was the study of the adherence to treatment in patients with systemic lupus erythematosus. Methods. Cross-sectional study including 132 consecutive patients with systemic lupus erythematosus (SLICC, 2012 classification criteria). We collected clinical and socio-demographic data, socio-economic status; we assessed SLEDAI-2k disease activity, and estimated the adherence to treatment by Morisky questionnaire. Results. Our results demonstrated that low adherence to treatment in patients with systemic lupus erythematosus was in only 11.36% of patients, while 43.18% and 45.46% of the patients were scored as moderate and high adherence, respectively. A moderate/high adherence to treatment was associated to a high level of education (r = −0.51, p < 0.05, 95% CI = −0.25 to −0.66), low disease activity (r = 0.38, p < 0.05, 95% CI = 0.25 to 0.53) and low indices of physician global assessment (r = −0.31, p<0.05, 95% CI = −0.23 to −0.71). The sub-analysis of the adherence to each drug demonstrated that the highest adherence was to treatment with glucocorticosteroids – 92.85%, followed by hydroxychloroquine and aspirin – 92.15% and 89.79%, respectively. Conclusion. In our cohort, the adherence to treatment was high in 45.46%, moderate in 43.18% and low in only 11.36% cases. High adherence to treatment was associated to low disease activity. The adherence was positively influenced by the age at the onset of the disease and a high educational level.

A CROSS-SECTIONAL STUDY OF CARDIAC INVOLVEMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS IN AN TERTIARY CARE CENTRE WITH EMPHASIS ON 2-D ECHOCARDIOGRAPHY

2021 ◽  
pp. 12-14
Author(s):  
Sourav Sadhukhan ◽  
Prabir Kumar Kundu ◽  
Sandip Ghosh ◽  
Aniruddha Ray
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Cardiac Involvement ◽  
General Medicine ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Pericardial Involvement

Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune inammatory rheumatologic disease. Its exact etiology is unknown and it can affect several organs—including skin, joints, kidneys, and many other organs. One of the organs reported to be involved in SLE is heart.1 The American Heart Association includes patients with SLE, especially women, as a high-risk group for cardiovascular diseases. Objectives: Find out cardiac involvement in patients of SLE. There is any relationship of cardiac involvement with the disease activity of SLE (SLEDAI-2K) Material And Methodology: Study Design: An observational cross-sectional study. Study settings and timeline: An 18 months Hospital Based study. Place of study: Department of General Medicine, RGKMCH. Period of study: 18 Months, from January 2018 to June 2019. Study population: The patients admitted in inpatients wards of Department of General Medicine and also OPD patients of R G Kar Medical College and Hospital who will fulll the inclusion criteria. Results And Analysis: In patients with active disease, 29(53.7%) patients had rst presentation. 25(46.3%) patients had rst presentation but disease activity was low. Association of rst presentation with disease activity was statistically signicant (p=0.0000406378). In patients with active disease, 36(66.7%) patients had cardiac involvement in any form. In patients with low disease activity, 11(50.0%) patients had cardiac involvement. Association of cardiac involvement with disease activity was not statistically signicant (p=0.2730132774). Out of total 47 patients with cardiac involvement, 27(57.4%) patients had pericardial involvement. Summary And Conclusion: Cardiac involvement is frequently seen in systemic lupus erythematosus patients, 61.8% in our study. Pericardium, myocardium, endocardium all can be involved in SLE. Pericardium is most commonly involved. Pulmonary hypertension, valvular abnormality, diastolic dysfunction, systolic dysfunction all are found in SLE. Echocardiography is an non –invasive excellent tool to evaluate the SLE patients for any cardiac involvement and serial screening of the patients. All cardiac manifestations are observed in active SLE patients in higher frequency but only pericardial involvement with disease activity is statistically signicant.

Clinical characteristics of itch in cutaneous lupus erythematosus: A prospective, multicenter, multinational, cross-sectional study

Lupus ◽  
2021 ◽  
pp. 096120332110160
Author(s):  
Dominik Samotij ◽  
Justyna Szczęch ◽  
Emiliano Antiga ◽  
Diletta Bonciani ◽  
Marzia Caproni ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Cutaneous Lupus Erythematosus ◽  
Cross Sectional Study ◽  
Skin Damage ◽  
Sectional Study ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Cutaneous Lupus

Objective Pruritus is an important symptom frequently accompanying various inflammatory skin conditions and some recent data indicated that it may be associated with autoimmune connective tissue diseases. The aim of this study was to assess the frequency and clinical presentation of itch in CLE. Methods A multinational, prospective, cross-sectional study was performed to assess the prevalence, intensity and clinical characteristic of pruritus in various subtypes of CLE. A total of 153 patients with active CLE lesions were included. Their age ranged between 17 and 82 years (mean 49.8 ± 15.4 years), and 115 patients (75.2%) were women. The disease activity and damage were assessed according to the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI). Pruritus severity was assessed with Numeric Rating Scale (NRS) and the 12-Item Pruritus Severity Scale. Dermatology Life Quality Index and EQ-5D questionnaire were used to measure quality of life. Results Pruritus was present in 116 (76.8%) of patients of whom half had NRS scoring equal or above 4 points indicating moderate or severe pruritus. Most commonly itch was localized on the scalp, face (excluding ears and nose) and arms (40.5%, 36.2%, 31.9%, respectively). Sensations connected with pruritus were most frequently described as burning, tingling and like ants crawling feeling, but 31.9% patients described it as “pure itch”. More than half of patients reported that pruritus was present every day, and it was most frequent during the evenings. The pruritus scoring and the CLASI activity score were significantly correlated (r = 0.42, p = 0.0001), while no correlation was found with the CLASI damage score (p = 0.16). Both the maximum and average itch intensity were correlated with systemic lupus erythematosus (SLE) activity measured with the Systemic Lupus Erythematosus Disease Activity Index. Conclusions Pruritus is a common, but frequently overlooked symptom of CLE. Its intensity correlates with the activity of CLE, but not with the skin damage. In more than a half of patients it occurs on a daily basis. The correlation between the intensity of pruritus and the activity of the skin lesions and the systemic involvement indicate that pruritus could be an individual indicator of both SLE and CLE activity.

Sign in / Sign up

Export Citation Format

Share Document