scholarly journals 212. TOLEROGENIC DENDRITIC CELLS REGULATE T CELLS VIA TRANSFORMING GROWTH FACTOR BETA

Rheumatology ◽  
2017 ◽  
Vol 56 (suppl_2) ◽  
Author(s):  
Oi Yean Wong ◽  
Catharien Hilkens
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Tolerogenic Dendritic Cells ◽  
Growth Factor Beta

scholarly journals Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis

2012 ◽  
Vol 34 (48) ◽  
pp. 3717-3727 ◽  
Author(s):  
Dirk Lievens ◽  
Kim L. Habets ◽  
Anna-Karin Robertson ◽  
Yasmina Laouar ◽  
Holger Winkels ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Immune Reactivity ◽  
Beta Receptor ◽  
Growth Factor Beta

Transforming growth factor-beta: An important role in CD4+CD25+regulatory T cells and immune tolerance

Autoimmunity ◽  
2006 ◽  
Vol 39 (4) ◽  
pp. 269-276 ◽  
Author(s):  
Lianjun Zhang ◽  
Huanfa Yi ◽  
Xue-Pei Xia ◽  
Yong Zhao
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Immune Tolerance ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Growth Factor Beta

OR.55. Transforming Growth Factor-beta is Crucial for the Differentiation and Regulation of Interleukin 9-producing Human CD4+T Cells

2009 ◽  
Vol 131 ◽  
pp. S24
Author(s):  
Gaelle Beriou ◽  
Cristina Costantino ◽  
Clare Baecher-Allan ◽  
David Hafler
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Cd4 T Cells ◽  
Transforming Growth Factor ◽  
Growth Factor Beta ◽  
Interleukin 9

Transforming Growth Factor-Beta: Antisense RNA-Mediated Inhibition Affects Anchorage-Independent Growth, Tumorigenicity and Tumor-Infiltrating T-Cells in Malignant Mesothelioma

1994 ◽  
Vol 11 (1) ◽  
pp. 29-44 ◽  
Author(s):  
David R. Fitzpatrick ◽  
Helle Bielefeldt-Ohmann ◽  
Robyn P. Himbeck ◽  
Andrew G. Jarnicki ◽  
Amanda L. Marzo ◽  
...  
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Malignant Mesothelioma ◽  
Transforming Growth Factor Beta ◽  
Antisense Rna ◽  
Transforming Growth Factor ◽  
Anchorage Independent Growth ◽  
Growth Factor Beta

Vaccination with transforming growth factor-beta insensitive dendritic cells suppresses pulmonary metastases of renal carcinoma in mice

2008 ◽  
Vol 271 (2) ◽  
pp. 333-341 ◽  
Author(s):  
Feng Tian ◽  
Longxin Wang ◽  
Weijun Qin ◽  
Fuli Wang ◽  
Bin Song ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Renal Carcinoma ◽  
Transforming Growth Factor ◽  
Pulmonary Metastases ◽  
Growth Factor Beta

scholarly journals Transforming Growth Factor Beta Signaling in Dendritic Cells Is Required for Immunotolerance to Sperm in the Epididymis

2018 ◽  
Vol 9 ◽  
Author(s):  
Fernando Pierucci-Alves ◽  
Monica T. Midura-Kiela ◽  
Sherry D. Fleming ◽  
Bruce D. Schultz ◽  
Pawel R. Kiela
Keyword(s):  
Dendritic Cells ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Growth Factor Beta

scholarly journals Identification of transforming growth factor-beta as a contaminant in factor VIII concentrates: a possible link with immunosuppressive effects in hemophiliacs

Blood ◽  
1994 ◽  
Vol 84 (6) ◽  
pp. 2021-2030
Author(s):  
M Wadhwa ◽  
P Dilger ◽  
J Tubbs ◽  
A Mire-Sluis ◽  
T Barrowcliffe ◽  
...  
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Factor Viii ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Interleukin 2 ◽  
Contributory Factor ◽  
Tgf Beta ◽  
Factor Viii Concentrates ◽  
Growth Factor Beta

In previous studies, we have shown that some, but not all low-, intermediate-, and high-purity factor VIII concentrates inhibit interleukin-2 (IL-2) secretion from phytohemagglutinin (PHA)-stimulated T lymphocytes. We now present evidence that this inhibitory action of concentrates is, at least in part, due to contamination with transforming growth factor-beta (TGF-beta). Originally identified in platelets, TGF-beta is a 25-kD homodimer that has been shown to be a natural and potent inhibitor of many immunologic responses. Using a specific bioassay, we have measured TGF-beta in various factor VIII concentrates. While some concentrates contained substantial amounts of the cytokine, there was a wide variation in concentrations of TGF-beta in different products. These levels correlated with the degree of inhibition of IL-2 secretion from T cells exhibited by each product (P = .0001). Noninhibitory concentrates contained no detectable TGF-beta. Addition of a specific TGF-beta 1 antibody reversed the inhibitory effect of some concentrates on IL-2 secretion by PHA-stimulated Jurkat T cells and interleukin-5 (IL-5)-induced proliferation of an erythroleukemic cell line. These findings suggest that TGF-beta contamination is a major contributory factor to the inhibitory activity of some factor VIII concentrates on cytokine secretion or activity, and may partially explain the reported immunosuppressive effects in recipients of these blood products.

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