scholarly journals 0660 The Association Between Sleep-Related Breathing Disorders and Free Flap Reconstruction Surgery in Patients With Oral and Oropharyngeal Cancers During 6-Month Follow-Up

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A252-A252
Author(s):  
L Fu-Hsin ◽  
C Chan-Chi ◽  
L Yu-Cheng ◽  
L Wei-Shu ◽  
L Cheng-Yu

Abstract Introduction Little was known about the association between sleep-related breathing disorders (SRBDs) and oral and oropharynx cancers (OOCs). To clarify the impact of free flap reconstruction on SRBDs, we performed a pilot study to investigate the change of SRBDs severity in patients with OOC before and after flap reconstruction surgery. Methods This study recruited 15 patients who were newly diagnosed with OOCs and expected to receive free flap reconstruction surgery. For each participant, polysomnography tests were performed repeatedly at the time of pre-operative, post-operative 1-week, and post-operative 6-month periods. Results All the subjects were male. Median age was 56 years (range 37-68). Mean of body mass index (BMI) was 24.5 (SD 5.8). Pre-operative apnea-hypopnea index (AHI) was 21.1/hour (SD 20.1). During post-operative 1-week period, BMI was 24.1(SD 5.8) and AHI was 40.2/hour (SD 27.9). During post-operative 6-month period, BMI was 23.4 (SD 3.3) and AHI was 33.3/hour (SD 21.6). Comparison between pre-operative and post-operative 6-month periods, there was no significant difference in BMI, but AHI increased significantly (21.1/hour v.s. 33.3/hour, P = 0.01). Conclusion Our study showed that OOCs patients with free flap reconstruction surgery had significantly increased AHI level during post-operative 1-week period. The SRBDs severity became partial remission after 6 months. We recommend that the head and neck cancer team should pay attention to the SRBDs issues in OOCs patients with free flap reconstruction surgery. Support  

Microsurgery ◽  
2019 ◽  
Author(s):  
Joseph S. Weisberger ◽  
Nicholas C. Oleck ◽  
Haripriya S. Ayyala ◽  
Radhika Malhotra ◽  
Edward S. Lee

Head & Neck ◽  
2004 ◽  
Vol 26 (10) ◽  
pp. 884-889 ◽  
Author(s):  
Karen B. Zur ◽  
Eric M. Genden ◽  
Mark L. Urken

2018 ◽  
Vol 34 (07) ◽  
pp. 492-498 ◽  
Author(s):  
Paul Heidekrueger ◽  
Elisabeth Haas ◽  
Michaela Coenen ◽  
Riccardo Giunta ◽  
Milomir Ninkovic ◽  
...  

Background Free tissue transfers can successfully address a wide range of reconstructive requirements. While the negative influence of cigarette smoking is well documented, its effects in the setting of microsurgical free flap reconstruction remain debated. This study evaluates the impact of cigarette smoking on microsurgical reconstructions. Methods Over a 7-year period, 897 patients underwent 969 microvascular free flap reconstructions at a single surgical center. The cases were divided into “smoker” (S) and “nonsmoker” (NS) groups according to their cigarette smoking status. The data were retrospectively screened for patients' demographics, perioperative details, surgical complications, free flap types, recipient sites, flap survival, and overall outcomes. Results Both groups were comparable regarding comorbidities including hypertension, peripheral artery disease, diabetes, American Society of Anesthesiologists scores, types of performed free flaps, and recipient sites. While patients in the NS group were significantly older and had a higher prevalence of obesity (p < 0.05), there were no significant differences regarding the rate of major or minor complications during our 3-month follow-up period (p > 0.05). Conclusion While minor and major complications were increased regarding virtually all examined parameters, cigarette smoking did not have significant effects on the overall outcomes of microsurgical free flap reconstructions.


Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2852
Author(s):  
Rosie Twomey ◽  
T. Wayne Matthews ◽  
Steven Nakoneshny ◽  
Christiaan Schrag ◽  
Shamir P. Chandarana ◽  
...  

Surgery with free flap reconstruction is a standard treatment for head and neck cancer (HNC). Because of the complexity of HNC surgery, recovery can be challenging, and complications are common. One of the foundations of enhanced recovery after surgery (ERAS) is early postoperative mobilization. The ERAS guidelines for HNC surgery with free flap reconstruction recommend mobilization within 24 h. This is based mainly on evidence from other surgical disciplines, and the extent to which mobilization within 24 h improves recovery after HNC surgery has not been explored. This retrospective analysis included 445 patients from the Calgary Head and Neck Enhanced Recovery Program. Mobilization after 24 h was associated with more complications of any type (OR = 1.73, 95% CI [confidence interval] = 1.16–2.57) and more major complications (OR = 1.76; 95% CI = 1.00–3.16). When accounting for patient and clinical factors, mobilization after 48 h was a significant predictor of major complications (OR = 2.61; 95% CI = 1.10–6.21) and prolonged length of stay (>10 days; OR = 2.85, 95% CI = 1.41–5.76). This comprehensive analysis of the impact of early mobilization on postoperative complications and length of stay in a large HNC cohort provides novel evidence supporting adherence to the ERAS early mobilization recommendations. Early mobilization should be a priority for patients undergoing HNC surgery with free flap reconstruction.


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