Development of a Physiologically Based Pharmacokinetic Model for Methyl tertiary-Butyl Ether and tertiary-Butanol in Male Fischer-344 Rats

S. J. BORGHOFF; J. E. MURPHY; M. A. MEDINSKY

doi:10.1093/toxsci/30.2.264

Development of a Physiologically Based Pharmacokinetic Model for Methyl tertiary-Butyl Ether and tertiary-Butanol in Male Fischer-344 Rats

Toxicological Sciences ◽

10.1093/toxsci/30.2.264 ◽

1996 ◽

Vol 30 (2) ◽

pp. 264-275 ◽

Cited By ~ 2

Author(s):

S. J. BORGHOFF ◽

J. E. MURPHY ◽

M. A. MEDINSKY

Keyword(s):

Pharmacokinetic Model ◽

Methyl Tertiary Butyl Ether ◽

Physiologically Based Pharmacokinetic Model ◽

Fischer 344 Rats ◽

Butyl Ether ◽

Tertiary Butyl ◽

Fischer 344 ◽

Physiologically Based Pharmacokinetic ◽

Tertiary Butanol ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Model of Methyl Tertiary Butyl Ether and Tertiary Butyl Alcohol Dosimetry in Male Rats Based on Binding to α2u-Globulin

Toxicological Sciences ◽

10.1093/toxsci/kfp049 ◽

2009 ◽

Vol 109 (2) ◽

pp. 321-335 ◽

Cited By ~ 13

Author(s):

Teresa L. Leavens ◽

Susan J. Borghoff

Keyword(s):

Pharmacokinetic Model ◽

Butyl Alcohol ◽

Male Rats ◽

Methyl Tertiary Butyl Ether ◽

Tertiary Butyl Alcohol ◽

Physiologically Based Pharmacokinetic Model ◽

Butyl Ether ◽

Tertiary Butyl ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Development of a Physiologically Based Pharmacokinetic Model for Methyltertiary-Butyl Ether andtertiary-Butanol in Male Fischer-344 Rats

Fundamental and Applied Toxicology ◽

10.1006/faat.1996.0064 ◽

1996 ◽

Vol 30 (2) ◽

pp. 264-275 ◽

Cited By ~ 33

Author(s):

S Borghoff

Keyword(s):

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Fischer 344 Rats ◽

Butyl Ether ◽

Fischer 344 ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically based pharmacokinetic rat model for methyl tertiary-butyl ether; comparison of selected dose metrics following various MTBE exposure scenarios used for toxicity and carcinogenicity evaluation

Toxicology ◽

10.1016/j.tox.2010.06.003 ◽

2010 ◽

Vol 275 (1-3) ◽

pp. 79-91 ◽

Cited By ~ 8

Author(s):

Susan J. Borghoff ◽

Horace Parkinson ◽

Teresa L. Leavens

Keyword(s):

Rat Model ◽

Methyl Tertiary Butyl Ether ◽

Butyl Ether ◽

Tertiary Butyl ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Dose Metrics

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A Physiologically Based Pharmacokinetic Model for Methyl tert-Butyl Ether in Humans: Implementing Sensitivity and Variability Analyses

Toxicological Sciences ◽

10.1093/toxsci/62.2.191 ◽

2001 ◽

Vol 62 (2) ◽

pp. 191-204 ◽

Cited By ~ 21

Author(s):

A. C. Licata

Keyword(s):

Pharmacokinetic Model ◽

Methyl Tert Butyl Ether ◽

Physiologically Based Pharmacokinetic Model ◽

Butyl Ether ◽

Tert Butyl ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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A Physiologically-Based Pharmacokinetic Model Assessment of Methyl t-Butyl Ether in Groundwater for a Bathing and Showering Determination

Risk Analysis ◽

10.1111/j.1539-6924.1997.tb00899.x ◽

1997 ◽

Vol 17 (5) ◽

pp. 583-598 ◽

Cited By ~ 25

Author(s):

Hari V. Rao ◽

Gary L. Ginsberg

Keyword(s):

Pharmacokinetic Model ◽

Model Assessment ◽

Physiologically Based Pharmacokinetic Model ◽

Butyl Ether ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Dose-Dependent Metabolism of 2,2-Dichloro-1,1,1-trifluoroethane: A Physiologically Based Pharmacokinetic Model in the Male Fischer 344 Rat

Toxicology and Applied Pharmacology ◽

10.1006/taap.1994.1233 ◽

1994 ◽

Vol 129 (1) ◽

pp. 103-113 ◽

Cited By ~ 23

Author(s):

A. Vinegar ◽

R.J. Williams ◽

J.W. Fisher ◽

J.N. Mcdougal

Keyword(s):

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Fischer 344 ◽

Physiologically Based Pharmacokinetic ◽

Fischer 344 Rat ◽

Physiologically Based ◽

Dose Dependent

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Physiologically based pharmacokinetic model for ethyltertiary-butyl ether andtertiary-butyl alcohol in rats: Contribution of binding to α2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes

Journal of Applied Toxicology ◽

10.1002/jat.3412 ◽

2016 ◽

Vol 37 (5) ◽

pp. 621-640 ◽

Cited By ~ 2

Author(s):

Susan J. Borghoff ◽

Caroline Ring ◽

Marcy I. Banton ◽

Teresa L. Leavens

Keyword(s):

Pharmacokinetic Model ◽

Butyl Alcohol ◽

Male Rats ◽

Physiologically Based Pharmacokinetic Model ◽

Cancer Outcomes ◽

Nonlinear Kinetics ◽

Butyl Ether ◽

High Exposure ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically based pharmacokinetic model development for trazodone: application to paediatric dose projection

10.26226/morressier.5971be87d462b80290b534f2 ◽

2017 ◽

Author(s):

F. Calisti

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Paediatric Dose

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Risk Assessment of Perfluorooctane Sulfonate (PFOS) using Dynamic Age Dependent Physiologically based Pharmacokinetic Model (PBPK) across human lifetime

Environmental Research ◽

10.1016/j.envres.2021.111287 ◽

2021 ◽

pp. 111287

Author(s):

Deepika Deepika ◽

Raju Prasad Sharma ◽

Marta Schuhmacher ◽

Vikas Kumar

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Model ◽

Perfluorooctane Sulfonate ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Age Dependent

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Human risk assessment of di-isobutyl phthalate through the application of a developed physiologically based pharmacokinetic model of di-isobutyl phthalate and its major metabolite mono-isobutyl phthalate

Archives of Toxicology ◽

10.1007/s00204-021-03057-5 ◽

2021 ◽

Author(s):

Seung-Hyun Jeong ◽

Ji-Hun Jang ◽

Hea-Young Cho ◽

Yong-Bok Lee

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Model ◽

Major Metabolite ◽

Physiologically Based Pharmacokinetic Model ◽

Human Risk Assessment ◽

Human Risk ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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