scholarly journals Metabolic Activation of Bisphenol A by Rat Liver S9 Fraction

2001 ◽  
Vol 62 (2) ◽  
pp. 221-227 ◽  
Author(s):  
S.'i. Yoshihara
Keyword(s):  
Bisphenol A ◽  
Rat Liver ◽  
Metabolic Activation ◽  
S9 Fraction

scholarly journals Evaluation of mutagenic activity of the pesticides: actara, sencor, mospilan, pencozeb, fastac in the Ames test

2008 ◽  
Vol 6 (4) ◽  
pp. 29-33 ◽  
Author(s):  
Nazira S Karamova ◽  
Alexandra P Denisova ◽  
Zenon Stasevski
Keyword(s):  
Salmonella Typhimurium ◽  
Rat Liver ◽  
Potato Plant ◽  
Ames Test ◽  
Mutagenic Activity ◽  
Metabolic Activation ◽  
Mutagenic Effect ◽  
Toxic Concentrations ◽  
S9 Fraction

The mutagenic activity of five pesticides actara, sencor, mospilan, pencozeb, fastac widely used for treatment of potato plant lands in Tatarstan was tested in the Ames test. The non toxic concentrations of the pesticides determined in preliminary cytotoxicty test were used in the Ames assay. Pesticides actara, mospilan, pencozeb, fastac did not show mutagenic effect in Salmonella typhimurium TA 100 without rat liver S9 fraction. The weak mutagenic effect of herbicide sencor was established at concentration 1 ug/plate. Metabolic activation in vitro using rat liver S9 fraction decreased the mutagenic activity of sencor and did not alter the mutagenicity rate of the pesticides actara, mospilan, pencozeb and fastac.

Metabolic Activation and Inactivation of Metanil Yellow and Orange II in the Salmonella typhimurium his− Reversion Assay

1996 ◽  
Vol 59 (3) ◽  
pp. 244-248 ◽  
Author(s):  
P. B. RASTOGI ◽  
R. E. LEVIN
Keyword(s):  
Salmonella Typhimurium ◽  
Rat Liver ◽  
Metabolic Activation ◽  
Flavin Mononucleotide ◽  
Orange Ii ◽  
Combined Use ◽  
Mutagenic Response ◽  
Experimental Protocols ◽  
Metanil Yellow ◽  
S9 Fraction

Among a variety of experimental protocols used, the combined use of 0.5% dextrose in bottom agar and 1 μmol of flavin mononucleotide (FMN) in preincubation mixtures without fraction S9 mix resulted in the highest level of induced Salmonella typhimurium his− reversions with both dyes metanil yellow and orange II with strain TA100. Strain TA98 yielded notably lower levels of reversions under the same conditions. The presence of uninduced hamster liver S9 fraction resulted in a weak mutagenic response while Aroclor 1254-induced rat liver S9 fraction resulted in the complete absence of mutagenicity with both strains and with both dyes.

Metabolic Activation of Procarcinogens to Genotoxic Products in Cultured Rat Liver Cells

Pathobiology ◽  
1984 ◽  
Vol 52 (6) ◽  
pp. 355-360
Author(s):  
G L. Murison ◽  
S D. Hall ◽  
A M. Lee
Keyword(s):  
Rat Liver ◽  
Metabolic Activation ◽  
Liver Cells ◽  
Rat Liver Cells

scholarly journals Inhibition of Genistein Glucuronidation by Bisphenol A in Human and Rat Liver Microsomes

2011 ◽  
Vol 40 (3) ◽  
pp. 481-485 ◽  
Author(s):  
Janis L. Coughlin ◽  
Paul E. Thomas ◽  
Brian Buckley
Keyword(s):  
Bisphenol A ◽  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Liver Microsomes

The role of metabolic activation by cytochrome P-450 in covalent binding of VP 16-213 to rat liver and HeLa cell microsomal proteins

1985 ◽  
Vol 21 (9) ◽  
pp. 1099-1106 ◽  
Author(s):  
J.M.S. van Maanen ◽  
C. de Ruiter ◽  
J. de Vries ◽  
P.R. Kootstra ◽  
F. Gobas ◽  
...  
Keyword(s):  
Hela Cell ◽  
Rat Liver ◽  
Covalent Binding ◽  
Metabolic Activation ◽  
Cytochrome P 450
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