scholarly journals Potent Estrogenic Metabolites of Bisphenol A and Bisphenol B Formed by Rat Liver S9 Fraction: Their Structures and Estrogenic Potency

2004 ◽  
Vol 78 (1) ◽  
pp. 50-59 ◽  
Author(s):  
S.'i. Yoshihara
Keyword(s):  
Bisphenol A ◽  
Rat Liver ◽  
S9 Fraction

scholarly journals Metabolic Activation of Bisphenol A by Rat Liver S9 Fraction

2001 ◽  
Vol 62 (2) ◽  
pp. 221-227 ◽  
Author(s):  
S.'i. Yoshihara
Keyword(s):  
Bisphenol A ◽  
Rat Liver ◽  
Metabolic Activation ◽  
S9 Fraction

scholarly journals Inhibition of Genistein Glucuronidation by Bisphenol A in Human and Rat Liver Microsomes

2011 ◽  
Vol 40 (3) ◽  
pp. 481-485 ◽  
Author(s):  
Janis L. Coughlin ◽  
Paul E. Thomas ◽  
Brian Buckley
Keyword(s):  
Bisphenol A ◽  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Liver Microsomes

scholarly journals Comparative GC-MS Based In vitro Assays of 5α-Reductase Activity Using Rat Liver S9 Fraction

2012 ◽  
Vol 3 (1) ◽  
pp. 21-24 ◽  
Author(s):  
Su-Hyeon Lee ◽  
Dong-Hyoung Lee ◽  
Jeong-Ae Lee ◽  
Won-Yong Lee ◽  
Bong-Chul Chung ◽  
...  
Keyword(s):  
Rat Liver ◽  
Reductase Activity ◽  
In Vitro Assays ◽  
S9 Fraction

scholarly journals Effect of metabolic transformation of monoterpenes on antimutagenic potential in bacterial tests

2012 ◽  
Vol 64 (3) ◽  
pp. 885-894 ◽  
Author(s):  
Biljana Nikolic ◽  
Dragana Mitic-Culafic ◽  
Olivera Stajkovic-Srbinovic ◽  
Branka Vukovic-Gacic ◽  
Jelena Knezevic-Vukcevic
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Spontaneous Mutagenesis ◽  
Butyl Hydroperoxide ◽  
E Coli ◽  
Antimutagenic Effect ◽  
Metabolic Transformation ◽  
S9 Fraction

The effect of metabolic transformation of the monoterpenes Linalool (Lin), Myrcene (Myr) and Eucalyptol (Euc) was evaluated on their antimutagenic potential against t-butyl hydroperoxide (t-BOOH) and 2-nitropropane (2NP) in E. coli WP2 and in S. typhimurium reversion assays, respectively. Spontaneous mutagenesis was also monitored in both assays. Mammalian metabolic transformation was provided by rat liver microsomes (S9 fraction). None of the monoterpenes was mutagenic, either with or without S9. Results obtained without S9 showed the antimutagenic potential of Lin against t-BOOH, of Myr against both t-BOOH and 2NP, and of Euc against spontaneous and mutagenesis induced with both mutagens. Mammalian enzymes significantly reduced the antimutagenic effect of Lin, completely diminished the antimutagenic effect of Myr, but did not alter the antimutagenic effect of Euc. Considering the results, metabolic transformation by host enzymes could significantly influence antimutagenic potential and should be included in antimutagenicity studies in prokaryotic assays.

scholarly journals Evaluation of mutagenic activity of the pesticides: actara, sencor, mospilan, pencozeb, fastac in the Ames test

2008 ◽  
Vol 6 (4) ◽  
pp. 29-33 ◽  
Author(s):  
Nazira S Karamova ◽  
Alexandra P Denisova ◽  
Zenon Stasevski
Keyword(s):  
Salmonella Typhimurium ◽  
Rat Liver ◽  
Potato Plant ◽  
Ames Test ◽  
Mutagenic Activity ◽  
Metabolic Activation ◽  
Mutagenic Effect ◽  
Toxic Concentrations ◽  
S9 Fraction

The mutagenic activity of five pesticides actara, sencor, mospilan, pencozeb, fastac widely used for treatment of potato plant lands in Tatarstan was tested in the Ames test. The non toxic concentrations of the pesticides determined in preliminary cytotoxicty test were used in the Ames assay. Pesticides actara, mospilan, pencozeb, fastac did not show mutagenic effect in Salmonella typhimurium TA 100 without rat liver S9 fraction. The weak mutagenic effect of herbicide sencor was established at concentration 1 ug/plate. Metabolic activation in vitro using rat liver S9 fraction decreased the mutagenic activity of sencor and did not alter the mutagenicity rate of the pesticides actara, mospilan, pencozeb and fastac.

scholarly journals Glucuronidation of the environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liver

1999 ◽  
Vol 340 (2) ◽  
pp. 405 ◽  
Author(s):  
Hiroshi YOKOTA ◽  
Hidetomo IWANO ◽  
Mari ENDO ◽  
Tsutomu KOBAYASHI ◽  
Hiroki INOUE ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Rat Liver ◽  
Udp Glucuronosyltransferase
Sign in / Sign up

Export Citation Format

Share Document