scholarly journals Female Sex Steroid Hormones and Pregnancy Regulate Receptors for Calcitonin Gene-Related Peptide in Rat Mesenteric Arteries, but Not in Aorta1

2004 ◽  
Vol 70 (4) ◽  
pp. 1055-1062 ◽  
Author(s):  
C. Yallampalli ◽  
S.B. Kondapaka ◽  
P. Lanlua ◽  
S.J. Wimalawansa ◽  
P.R.R. Gangula
Keyword(s):  
Steroid Hormones ◽  
Calcitonin Gene Related Peptide ◽  
Sex Steroid Hormones ◽  
Mesenteric Arteries ◽  
Sex Steroid ◽  
Related Peptide ◽  
Female Sex ◽  
Calcitonin Gene

scholarly journals Regulation of Calcitonin Gene-Related Peptide Expression in Dorsal Root Ganglia of Rats by Female Sex Steroid Hormones1

2000 ◽  
Vol 62 (4) ◽  
pp. 1033-1039 ◽  
Author(s):  
P.R.R. Gangula ◽  
P. Lanlua ◽  
S. Wimalawansa ◽  
S. Supowit ◽  
D. DiPette ◽  
...  
Keyword(s):  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Calcitonin Gene Related Peptide ◽  
Sex Steroid ◽  
Related Peptide ◽  
Female Sex ◽  
Calcitonin Gene ◽  
Peptide Expression

scholarly journals Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly

2020 ◽  
Vol 40 (5) ◽  
pp. 1207-1219 ◽  
Author(s):  
Jennifer van der Horst ◽  
Rian W. Manville ◽  
Katie Hayes ◽  
Morten B. Thomsen ◽  
Geoffrey W. Abbott ◽  
...  
Keyword(s):  
Preventive Intervention ◽  
Ex Vivo ◽  
Calcitonin Gene Related Peptide ◽  
Mesenteric Arteries ◽  
Benzoquinone Imine ◽  
Kv7 Channels ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Perivascular Nerves ◽  
Life Threatening

Objective: Intravenous acetaminophen/paracetamol (APAP) is well documented to cause hypotension. Since the patients receiving intravenous APAP are usually critically ill, any severe hemodynamic changes, as with those associated with APAP, can be life-threatening. The mechanism underlying this dangerous iatrogenic effect of APAP was unknown. Approach and Results: Here, we show that intravenous APAP caused transient hypotension in rats, which was attenuated by the Kv7 channel blocker, linopirdine. APAP metabolite N-acetyl-p-benzoquinone imine caused vasodilatation of rat mesenteric arteries ex vivo. This vasodilatation was sensitive to linopirdine and also the calcitonin gene-related peptide antagonist, BIBN 4096. Further investigation revealed N-acetyl-p-benzoquinone imine stimulates calcitonin gene-related peptide release from perivascular nerves, causing a cAMP-dependent activation of Kv7 channels. We also show that N-acetyl-p-benzoquinone imine enhances Kv7.4 and Kv7.5 channels overexpressed in oocytes, suggesting that it can activate Kv7.4 and Kv7.5 channels directly, to elicit vasodilatation. Conclusions: Direct and indirect activation of Kv7 channels by the APAP metabolite N-acetyl-p-benzoquinone imine decreases arterial tone, which can lead to a drop in blood pressure. Our findings provide a molecular mechanism and potential preventive intervention for the clinical phenomenon of intravenous APAP-dependent transient hypotension.

Oligodendrocyte Progenitor Proliferation and Maturation Is Differentially Regulated by Male and Female Sex Steroid Hormones

2004 ◽  
Vol 26 (2-4) ◽  
pp. 245-254 ◽  
Author(s):  
Mireya Marin-Husstege ◽  
Michela Muggironi ◽  
David Raban ◽  
Robert P. Skoff ◽  
Patrizia Casaccia-Bonnefil
Keyword(s):  
Steroid Hormones ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Male And Female ◽  
Oligodendrocyte Progenitor ◽  
Female Sex
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