scholarly journals Intrauterine Growth Retardation in Endothelial Nitric Oxide Synthase-Deficient Mice Is Established from Early Stages of Pregnancy1

2008 ◽  
Vol 78 (6) ◽  
pp. 1002-1006 ◽  
Author(s):  
Pilar Pallares ◽  
Antonio Gonzalez-Bulnes
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Growth Retardation ◽  
Endothelial Nitric Oxide Synthase ◽  
Intrauterine Growth Retardation ◽  
Intrauterine Growth ◽  
Early Stages ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Deficient Mice

P4-061: INCREASED UREA LEVELS IN THE BRAIN OF ENDOTHELIAL NITRIC OXIDE SYNTHASE DEFICIENT MICE

2006 ◽  
Vol 14 (7S_Part_27) ◽  
pp. P1456-P1456
Author(s):  
Ashwini Hariharan ◽  
Yu Jing ◽  
Nicola D. Collie ◽  
Hu Zhang ◽  
Ping Liu
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
The Brain ◽  
Deficient Mice

Cortico-striatal synaptic plasticity in endothelial nitric oxide synthase deficient mice

2003 ◽  
Vol 964 (1) ◽  
pp. 159-163 ◽  
Author(s):  
Nanuli Doreulee ◽  
Olga A Sergeeva ◽  
Yevgeni Yanovsky ◽  
Aisa N Chepkova ◽  
Oliver Selbach ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Synaptic Plasticity ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Deficient Mice

scholarly journals Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice

2018 ◽  
Vol 82 (4) ◽  
pp. 1195-1204 ◽  
Author(s):  
Yukio Hiroi ◽  
Kensuke Noma ◽  
Hyung-Hwan Kim ◽  
Nikola Sladojevic ◽  
Corey E. Tabit ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Coiled Coil ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Deficient Mice

scholarly journals Vasodilator mechanisms in the coronary circulation of endothelial nitric oxide synthase-deficient mice

2000 ◽  
Vol 279 (4) ◽  
pp. H1906-H1912 ◽  
Author(s):  
Kathryn G. Lamping ◽  
Daniel W. Nuno ◽  
Edward G. Shesely ◽  
Nobuyo Maeda ◽  
Frank M. Faraci
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Coronary Arteries ◽  
Endothelial Nitric Oxide Synthase ◽  
Coronary Circulation ◽  
Wild Type ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Endothelium Dependent Relaxation ◽  
Deficient Mice

Previous studies have demonstrated that responses to endothelium-dependent vasodilators are absent in the aortas from mice deficient in expression of endothelial nitric oxide synthase (eNOS −/− mice), whereas responses in the cerebral microcirculation are preserved. We tested the hypothesis that in the absence of eNOS, other vasodilator pathways compensate to preserve endothelium-dependent relaxation in the coronary circulation. Diameters of isolated, pressurized coronary arteries from eNOS −/−, eNOS heterozygous (+/−), and wild-type mice (eNOS +/+ and C57BL/6J) were measured by video microscopy. ACh (an endothelium-dependent agonist) produced vasodilation in wild-type mice. This response was normal in eNOS +/− mice and was largely preserved in eNOS −/− mice. Responses to nitroprusside were also similar in arteries from eNOS +/+, eNOS +/−, and eNOS −/− mice. Dilation to ACh was inhibited by N G-nitro-l-arginine, an inhibitor of NOS in control and eNOS −/− mice. In contrast, trifluoromethylphenylimidazole, an inhibitor of neuronal NOS (nNOS), decreased ACh-induced dilation in arteries from eNOS-deficient mice but had no effect on responses in wild-type mice. Indomethacin, an inhibitor of cyclooxygenase, decreased vasodilation to ACh in eNOS-deficient, but not wild-type, mice. Thus, in the absence of eNOS, dilation of coronary arteries to ACh is preserved by other vasodilator mechanisms.

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