scholarly journals Pregnancy and Steroid Hormones Enhance the Systemic and Regional Hemodynamic Effects of Calcitonin Gene-Related Peptide in Rats1

2001 ◽  
Vol 64 (6) ◽  
pp. 1776-1783 ◽  
Author(s):  
P.R.R. Gangula ◽  
H. Zhao ◽  
S.J. Wimalawansa ◽  
S.C. Supowit ◽  
D.J. DiPette ◽  
...  
Keyword(s):  
Steroid Hormones ◽  
Calcitonin Gene Related Peptide ◽  
Hemodynamic Effects ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Regional Hemodynamic Effects of Adrenomedullin in Wistar Rats: A Comparison with Calcitonin Gene-Related Peptide.

2002 ◽  
Vol 25 (3) ◽  
pp. 441-446 ◽  
Author(s):  
Junsuke KAWAI ◽  
Katsuyuki ANDO ◽  
Tatsuo SHIMOSAWA ◽  
Kiyonori HARII ◽  
Toshiro FUJITA
Keyword(s):  
Wistar Rats ◽  
Calcitonin Gene Related Peptide ◽  
Hemodynamic Effects ◽  
Related Peptide ◽  
Calcitonin Gene

Hemodynamic effects of calcitonin gene-related peptide in conscious rats

1987 ◽  
Vol 19 (5-6) ◽  
pp. 307-312 ◽  
Author(s):  
Rodney W. Lappe ◽  
Mark J. Slivjak ◽  
Joy A. Todt ◽  
Robert L. Wendt
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Hemodynamic Effects ◽  
Conscious Rats ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Systemic and regional hemodynamic effects of calcitonin gene-related peptide.

Hypertension ◽  
1987 ◽  
Vol 9 (6_pt_2) ◽  
Author(s):  
D J DiPette ◽  
K Schwarzenberger ◽  
N Kerr ◽  
O B Holland
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Hemodynamic Effects ◽  
Related Peptide ◽  
Calcitonin Gene

Hemodynamic effects of calcitonin gene-related peptide in spontaneously hypertensive rats

1990 ◽  
Vol 258 (2) ◽  
pp. R425-R429 ◽  
Author(s):  
K. Ando ◽  
B. L. Pegram ◽  
E. D. Frohlich
Keyword(s):  
Arterial Pressure ◽  
Total Peripheral Resistance ◽  
Spontaneously Hypertensive Rats ◽  
Peripheral Resistance ◽  
Calcitonin Gene Related Peptide ◽  
Hemodynamic Effects ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Related Peptide ◽  
Calcitonin Gene

Systemic and regional hemodynamic effects of intravenously injected calcitonin gene-related peptide (CGRP), 220 and 650 pmol, were compared in nine Wistar-Kyoto (WKY) and nine spontaneously hypertensive rats (SHR). CGRP (higher dose) reduced mean arterial pressure (from 135 +/- 2 to 83 +/- 2 and from 179 +/- 4 to 116 +/- 3 mmHg; P less than 0.01, each, in WKY and SHR, respectively) through a fall (-38 +/- 4 and -40 +/- 3%; P less than 0.01) in total peripheral resistance associated with an unchanged cardiac output and an increased heart rate. The decreases in arterial pressure and total peripheral resistance were not different between these two strains. Of particular significance were the highly selective reductions in organ vascular resistances, being greatest in the cutaneous (-78 +/- 3 and -67 +/- 4%) and gastric (-80 +/- 3 and -84 +/- 2%) circulations in WKY and SHR, respectively (P less than 0.01). Reduction in coronary, cerebral, and hepatic vascular resistances, although significant (P less than 0.05, at least), were only moderately reduced compared with the two former circulations. These effects were similar in WKY and SHR and demonstrate that CGRP is a highly selective and potent natural vasodilating peptide that has the most striking effects in skin and stomach, suggesting possible modulator functions in regulating certain regional hemodynamics.

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