scholarly journals Effects of early life stress on stimulant self‐administration in rhesus monkeys

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Sarah B. Ewing ◽  
Leonard L. Howell
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Rhesus Monkeys ◽  
Early Life Stress ◽  
Self Administration

scholarly journals Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats

2020 ◽  
Author(s):  
Ludovic D. Langlois ◽  
Rina Y. Berman ◽  
Ryan D. Shepard ◽  
Sarah C. Simmons ◽  
Mumeko C. Tsuda ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Sucrose Preference ◽  
Male Rats ◽  
Self Administration ◽  
Lateral Habenula ◽  
Glutamatergic Synaptic Transmission ◽  
Intravenous Morphine

AbstractEarly life stress (ELS) presents an important risk factor for drug addiction and comorbid depression and anxiety through persistent effects on the mesolimbic dopamine (DA) pathways1. Using an ELS model for child neglect (a single 24 h episode of maternal deprivation, MD) in rats, recent published works from our lab show that MD induces dysfunction in ventral tegmental area (VTA) DA neurons 2–4 and its negative controller, the lateral habenula (LHb) 5–7. In regard to LHb, MD-induced potentiation of glutamatergic synaptic transmission onto LHb neurons shifts the coordination of excitation/inhibition (E/I) balance towards excitation, resulting in an increase in the overall spontaneous neuronal activity with elevation in bursting and tonic firing, and intrinsic excitability of LHb neurons in early adolescent male rats 5–7. Here, we explored how MD affects intravenous morphine self-administration (MSA) acquisition and sucrose preference as well as glutamatergic synaptic function in LHb neurons of adult male rats self-administering morphine. We found that MD-induced increases in LHb neuronal and glutamatergic synaptic activity and E/I ratio persisted into adulthood. Moreover, MD significantly reduced morphine intake, triggered anhedonia-like behavior in the sucrose preference test (SPT), and was associated with persistent glutamatergic potentiation 24h after the last MSA session. MSA also triggered postsynaptic glutamatergic potentiation in LHb neurons of control rats during this time period. Our data highlights that ELS-induced glutamatergic plasticity in LHb may dampen the positive reinforcing properties of natural rewards and opioids, and contribute to the development of anhedonic and dysphoric states associated with opioids.

scholarly journals Adolescent Stress Increases Adult Ethanol Self-administration and Alters Ventral Tegmental Area GABA Signaling

2019 ◽  
Author(s):  
David A Connor ◽  
Ruthie E Wittenberg ◽  
Jillian Drogin ◽  
Allison Mak ◽  
John A Dani
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Alcohol Use Disorders ◽  
Early Life Stress ◽  
Male Rats ◽  
Stress Exposure ◽  
Self Administration ◽  
Adolescent Stress ◽  
Gaba Signaling

AbstractAlcohol use disorders (AUDs) continue to be a significant public health problem. Early life stress and adversity have long-lasting effects on a wide range of behaviors, including responses to drugs of abuse. Epidemiological evidence indicates that exposure to early life stress contributes to alcohol use disorders and, while it is known that stress and alcohol both act on overlapping mesolimbic circuitry, the cellular mechanisms underlying the relationship between stress and alcohol intake are not well understood. Previous work has demonstrated that acute stress increases ethanol intake mediated by changes in GABA signaling within the ventral tegmental area (VTA). Here we investigated if adolescent stress exposure might elicit long-term, persistent increases in ethanol self-administration associated with altered VTA GABA signaling. To this end, we exposed adolescent postnatal day (PND) 28 male rats to 14 days of chronic variable stress (CVS) and then examined operant ethanol self-administration begun at least 30 days later. We found that adolescent stress exposure resulted in significantly increased ethanol self-administration in adulthood. In contrast, adult (PND 82) male rats exposed to the same CVS protocol did not display increased ethanol self-administration that was begun 30 days later. Furthermore, we found that adolescent stress exposure resulted in enhancement of ethanol-induced GABA signaling onto VTA dopamine neurons and impairments in VTA GABA chloride homeostasis. The results indicate that adolescence is a period vulnerable to stress, which produces long-term changes in VTA GABA signaling associated with increased ethanol self-administration behavior.

P.6.a.009 Increased ethanol self-administration associated with synaptic plasticity alterations induced by early life stress in mice

2014 ◽  
Vol 24 ◽  
pp. S657-S658
Author(s):  
M.S. Garcia-Gutierrez ◽  
F. Navarrete ◽  
A. Aracil-Fernández ◽  
A. Bartoll ◽  
J. Lanciego ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Self Administration

Effects of early life stress on cocaine self-administration in post-pubertal male and female rhesus macaques

2019 ◽  
Vol 236 (9) ◽  
pp. 2785-2796 ◽  
Author(s):  
Alison G. P. Wakeford ◽  
Elyse L. Morin ◽  
Sara N. Bramlett ◽  
Brittany R. Howell ◽  
Kai M. McCormack ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Rhesus Macaques ◽  
Early Life Stress ◽  
Self Administration ◽  
Male And Female ◽  
Female Rhesus ◽  
Female Rhesus Macaques

scholarly journals Early life stress affects cerebral glucose metabolism in adult rhesus monkeys (Macaca mulatta)

2012 ◽  
Vol 2 (1) ◽  
pp. 181-193 ◽  
Author(s):  
Lisa A. Parr ◽  
Matthew Boudreau ◽  
Erin Hecht ◽  
James T. Winslow ◽  
Charles B. Nemeroff ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Macaca Mulatta ◽  
Life Stress ◽  
Early Life ◽  
Rhesus Monkeys ◽  
Early Life Stress ◽  
Cerebral Glucose Metabolism

scholarly journals Effects of Early-Life Stress on Serotonin1A Receptors in Juvenile Rhesus Monkeys Measured by Positron Emission Tomography

2010 ◽  
Vol 67 (12) ◽  
pp. 1146-1153 ◽  
Author(s):  
Simona Spinelli ◽  
Svetlana Chefer ◽  
Richard E. Carson ◽  
Elaine Jagoda ◽  
Lixin Lang ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Life Stress ◽  
Early Life ◽  
Rhesus Monkeys ◽  
Early Life Stress ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Early Life Stress Promotes Heroin Seeking But Does Not Alter the Excitability of Insular Pyramidal Cells Targeting the Nucleus Accumbens

2021 ◽  
Vol 15 ◽  
Author(s):  
Jonna M. Leyrer-Jackson ◽  
Paula F. Overby ◽  
Erin K. Nagy ◽  
M. Foster Olive
Keyword(s):  
Nucleus Accumbens ◽  
Adverse Childhood Experiences ◽  
Life Stress ◽  
Early Life ◽  
Pyramidal Neurons ◽  
Early Life Stress ◽  
Self Administration ◽  
Childhood Experiences ◽  
Adverse Childhood ◽  
Seeking Behavior

A number of retrospective studies have demonstrated adverse childhood experiences are associated with increased vulnerability to substance use disorders, including opioid use disorders (OUDs). These adverse childhood experiences, also referred to as early life stress (ELS), can be modeled in laboratory animals by various paradigms including limited bedding and nesting (LBN) procedures. Studies using rodent models of ELS have been shown to recapitulate various aspects of OUDs, including relapse propensity and perseverance of drug-seeking behavior. In the current study, we utilized the LBN paradigm to explore potential effects on heroin self-administration, extinction, and relapse-like behaviors in male and female rats. We also utilized in vitro whole-cell electrophysiology to examine the effects of LBN and repeated heroin administration on the excitability of pyramidal neurons in the anterior insular cortex (AIC) projecting to the nucleus accumbens core (NAc), as recent studies suggest that this circuit may mediate various aspects of OUDs and may be compromised as a result of either ELS or OUDs. We observed that compared to control animals, rats exposed to LBN conditions during postnatal days 2–9 showed increased breakpoints for heroin self-administration under a progressive ratio schedule of reinforcement, impaired extinction of heroin-seeking behavior, and increased reinstatement of heroin-seeking behavior induced by heroin-associated cues. No effect of LBN rearing conditions were observed on the acquisition and maintenance of heroin self-administration, and no sex differences in heroin intake were observed. LBN and control reared animals showed no differences in the excitability of AIC-NAc pyramidal neurons, but animals treated with repeated heroin showed decreased excitability of these neurons through a significant increase in rheobase and reduction in action potentials induced by depolarizing currents. Together, these results suggest that ELS exposure produces exacerbations of heroin seeking behavior without parallel effects on AIC-NAc excitability, although heroin itself reduces the excitability of these neurons.

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